Chronic palmitoylethanolamide administration via slow-release subcutaneous pellets promotes neuroprotection and mitigates neuroinflammation in the Tg2576 mouse model of Alzheimer’s disease

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by cognitive and non-cognitive decline associated with neuropathological hallmarks, including neuroinflammation. Palmitoylethanolamide (PEA), an endogenous lipid with anti-inflammatory and neuroprotective properties,...

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Main Authors:	Daniel Tortolani, Davide Decandia, Giacomo Giacovazzo, Lucia Scipioni, Anna Panuccio, Francesca Ciaramellano, Fabiola Eugelio, Federico Fanti, Emanuele Claudio Latagliata, Livia La Barbera, Debora Cutuli, Dario Compagnone, Marcello D’Amelio, Roberto Coccurello, Sergio Oddi, Laura Petrosini, Mauro Maccarrone
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-04-01
Series:	Frontiers in Cellular Neuroscience
Subjects:	Alzheimer’s disease ultramicronized palmitoylethanolamide oxidative stress neuroinflammation dendritic spine density memory
Online Access:	https://www.frontiersin.org/articles/10.3389/fncel.2025.1571428/full
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Chronic palmitoylethanolamide administration via slow-release subcutaneous pellets promotes neuroprotection and mitigates neuroinflammation in the Tg2576 mouse model of Alzheimer’s disease

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