0.5ZnO@Cu5.4O nanoparticle for regulates the expression of GSDMB and targeted therapy of tumor
Abstract GSDMB, a key protein in pyroptosis, is closely linked to various diseases. Nanomaterials can target and regulate specific pathways. Herein, we report a simple and efficient one-step method to develop multi-enzyme nanoparticles capable of suppressing GSDMB expression. 0.5ZnO@Cu5.4O can inhib...
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| Format: | Article |
| Language: | English |
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BMC
2025-06-01
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| Series: | Cancer Cell International |
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| Online Access: | https://doi.org/10.1186/s12935-025-03874-z |
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| _version_ | 1849433141594292224 |
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| author | Hao Zhang Guoyan Liu |
| author_facet | Hao Zhang Guoyan Liu |
| author_sort | Hao Zhang |
| collection | DOAJ |
| description | Abstract GSDMB, a key protein in pyroptosis, is closely linked to various diseases. Nanomaterials can target and regulate specific pathways. Herein, we report a simple and efficient one-step method to develop multi-enzyme nanoparticles capable of suppressing GSDMB expression. 0.5ZnO@Cu5.4O can inhibit GSDMB, a capability that neither ZnO nor Cu5.4O possesses. ZnO@Cu5.4O with different ratios also exhibits varying inhibitory effects. The 0.5ZnO@Cu5.4O can be cleared quickly in vivo, ensuring biocompatibility. Additionally, 0.5ZnO@Cu5.4O significantly inhibits tumor progression, offering promising avenues for clinical cancer therapy, and the development of gene-regulating nanoparticles. |
| format | Article |
| id | doaj-art-0e8ca5b3260447dc9aa294d3797e259e |
| institution | Kabale University |
| issn | 1475-2867 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Cancer Cell International |
| spelling | doaj-art-0e8ca5b3260447dc9aa294d3797e259e2025-08-20T03:27:10ZengBMCCancer Cell International1475-28672025-06-0125111010.1186/s12935-025-03874-z0.5ZnO@Cu5.4O nanoparticle for regulates the expression of GSDMB and targeted therapy of tumorHao Zhang0Guoyan Liu1Department of Gastrointestinal Surgery, Xiang’an Hospital of Xiamen University, School of Medicine, Xiamen UniversityDepartment of Gastrointestinal Surgery, Xiang’an Hospital of Xiamen University, School of Medicine, Xiamen UniversityAbstract GSDMB, a key protein in pyroptosis, is closely linked to various diseases. Nanomaterials can target and regulate specific pathways. Herein, we report a simple and efficient one-step method to develop multi-enzyme nanoparticles capable of suppressing GSDMB expression. 0.5ZnO@Cu5.4O can inhibit GSDMB, a capability that neither ZnO nor Cu5.4O possesses. ZnO@Cu5.4O with different ratios also exhibits varying inhibitory effects. The 0.5ZnO@Cu5.4O can be cleared quickly in vivo, ensuring biocompatibility. Additionally, 0.5ZnO@Cu5.4O significantly inhibits tumor progression, offering promising avenues for clinical cancer therapy, and the development of gene-regulating nanoparticles.https://doi.org/10.1186/s12935-025-03874-zGSDMBNanoparticlesTumor |
| spellingShingle | Hao Zhang Guoyan Liu 0.5ZnO@Cu5.4O nanoparticle for regulates the expression of GSDMB and targeted therapy of tumor Cancer Cell International GSDMB Nanoparticles Tumor |
| title | 0.5ZnO@Cu5.4O nanoparticle for regulates the expression of GSDMB and targeted therapy of tumor |
| title_full | 0.5ZnO@Cu5.4O nanoparticle for regulates the expression of GSDMB and targeted therapy of tumor |
| title_fullStr | 0.5ZnO@Cu5.4O nanoparticle for regulates the expression of GSDMB and targeted therapy of tumor |
| title_full_unstemmed | 0.5ZnO@Cu5.4O nanoparticle for regulates the expression of GSDMB and targeted therapy of tumor |
| title_short | 0.5ZnO@Cu5.4O nanoparticle for regulates the expression of GSDMB and targeted therapy of tumor |
| title_sort | 0 5zno cu5 4o nanoparticle for regulates the expression of gsdmb and targeted therapy of tumor |
| topic | GSDMB Nanoparticles Tumor |
| url | https://doi.org/10.1186/s12935-025-03874-z |
| work_keys_str_mv | AT haozhang 05znocu54onanoparticleforregulatestheexpressionofgsdmbandtargetedtherapyoftumor AT guoyanliu 05znocu54onanoparticleforregulatestheexpressionofgsdmbandtargetedtherapyoftumor |