Lacticaseibacillus rhamnosus HM126 Alleviates Allergic Rhinitis by Modulating the Intestinal Flora and Metabolites in Mice
We investigated the role of Lacticaseibacillus rhamnosus HM126 in the prevention and alleviation of ovalbumin-induced allergic rhinitis (AR) in mice. We also analyzed the composition of the gut microbiota and the differences in metabolite profile using 16S rRNA gene sequencing and untargeted metabol...
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China Food Publishing Company
2025-07-01
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| Series: | Shipin Kexue |
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| Online Access: | https://www.spkx.net.cn/fileup/1002-6630/PDF/2025-46-14-017.pdf |
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| author | YUAN Xueping, ZHAO Yujin, LI Xianping, ZHANG Yu, LI Xiaojing, YAO Chunyu, TANG Mi, LIU Lu, ZHAO Junying, QIAO Weicang, GAO Ziqing, CHEN Lijun |
| author_facet | YUAN Xueping, ZHAO Yujin, LI Xianping, ZHANG Yu, LI Xiaojing, YAO Chunyu, TANG Mi, LIU Lu, ZHAO Junying, QIAO Weicang, GAO Ziqing, CHEN Lijun |
| author_sort | YUAN Xueping, ZHAO Yujin, LI Xianping, ZHANG Yu, LI Xiaojing, YAO Chunyu, TANG Mi, LIU Lu, ZHAO Junying, QIAO Weicang, GAO Ziqing, CHEN Lijun |
| collection | DOAJ |
| description | We investigated the role of Lacticaseibacillus rhamnosus HM126 in the prevention and alleviation of ovalbumin-induced allergic rhinitis (AR) in mice. We also analyzed the composition of the gut microbiota and the differences in metabolite profile using 16S rRNA gene sequencing and untargeted metabolomics, respectively. The results showed that the nasal symptoms of AR mice were significantly reduced and the nasal function was restored to normal after intervention with L. rhamnosus HM126. The correlation analysis between the gut flora and metabolome revealed that this strain could alleviate AR symptoms by modulating the relative abundance of the gut flora and inducing an increase in metabolites such as quinic acid, leptomycin b, ketoprofen, 18 alpha-glycyrrhetinic acid, and asiatic acid. This study suggested that L. rhamnosus HM126 can ameliorate allergic inflammatory response by regulating gut microbiota dysbiosis and producing immunomodulatory substances in mice, providing theoretical support for the alleviation of AR by probiotics. |
| format | Article |
| id | doaj-art-0e86bda3c04340b39c951e89dbb4bab8 |
| institution | DOAJ |
| issn | 1002-6630 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | China Food Publishing Company |
| record_format | Article |
| series | Shipin Kexue |
| spelling | doaj-art-0e86bda3c04340b39c951e89dbb4bab82025-08-20T03:12:32ZengChina Food Publishing CompanyShipin Kexue1002-66302025-07-01461415715510.7506/spkx1002-6630-20250102-012Lacticaseibacillus rhamnosus HM126 Alleviates Allergic Rhinitis by Modulating the Intestinal Flora and Metabolites in MiceYUAN Xueping, ZHAO Yujin, LI Xianping, ZHANG Yu, LI Xiaojing, YAO Chunyu, TANG Mi, LIU Lu, ZHAO Junying, QIAO Weicang, GAO Ziqing, CHEN Lijun0(1. School of Biological Engineering, Dalian Polytechnic University, Dalian 116034, China; 2. National Engineering Research Center of Dairy Health for Maternal and Child, Beijing Engineering Research Center of Dairy, Beijing Technical Innovation Center of Human Milk Research, Beijing Sanyuan Foods Co. Ltd., Beijing 100163, China; 3. College of Food Science, Northeast Agricultural University, Harbin 150030, China)We investigated the role of Lacticaseibacillus rhamnosus HM126 in the prevention and alleviation of ovalbumin-induced allergic rhinitis (AR) in mice. We also analyzed the composition of the gut microbiota and the differences in metabolite profile using 16S rRNA gene sequencing and untargeted metabolomics, respectively. The results showed that the nasal symptoms of AR mice were significantly reduced and the nasal function was restored to normal after intervention with L. rhamnosus HM126. The correlation analysis between the gut flora and metabolome revealed that this strain could alleviate AR symptoms by modulating the relative abundance of the gut flora and inducing an increase in metabolites such as quinic acid, leptomycin b, ketoprofen, 18 alpha-glycyrrhetinic acid, and asiatic acid. This study suggested that L. rhamnosus HM126 can ameliorate allergic inflammatory response by regulating gut microbiota dysbiosis and producing immunomodulatory substances in mice, providing theoretical support for the alleviation of AR by probiotics.https://www.spkx.net.cn/fileup/1002-6630/PDF/2025-46-14-017.pdfallergic rhinitis; probiotics; lacticaseibacillus rhamnosus; untargeted metabolomics; gut flora |
| spellingShingle | YUAN Xueping, ZHAO Yujin, LI Xianping, ZHANG Yu, LI Xiaojing, YAO Chunyu, TANG Mi, LIU Lu, ZHAO Junying, QIAO Weicang, GAO Ziqing, CHEN Lijun Lacticaseibacillus rhamnosus HM126 Alleviates Allergic Rhinitis by Modulating the Intestinal Flora and Metabolites in Mice Shipin Kexue allergic rhinitis; probiotics; lacticaseibacillus rhamnosus; untargeted metabolomics; gut flora |
| title | Lacticaseibacillus rhamnosus HM126 Alleviates Allergic Rhinitis by Modulating the Intestinal Flora and Metabolites in Mice |
| title_full | Lacticaseibacillus rhamnosus HM126 Alleviates Allergic Rhinitis by Modulating the Intestinal Flora and Metabolites in Mice |
| title_fullStr | Lacticaseibacillus rhamnosus HM126 Alleviates Allergic Rhinitis by Modulating the Intestinal Flora and Metabolites in Mice |
| title_full_unstemmed | Lacticaseibacillus rhamnosus HM126 Alleviates Allergic Rhinitis by Modulating the Intestinal Flora and Metabolites in Mice |
| title_short | Lacticaseibacillus rhamnosus HM126 Alleviates Allergic Rhinitis by Modulating the Intestinal Flora and Metabolites in Mice |
| title_sort | lacticaseibacillus rhamnosus hm126 alleviates allergic rhinitis by modulating the intestinal flora and metabolites in mice |
| topic | allergic rhinitis; probiotics; lacticaseibacillus rhamnosus; untargeted metabolomics; gut flora |
| url | https://www.spkx.net.cn/fileup/1002-6630/PDF/2025-46-14-017.pdf |
| work_keys_str_mv | AT yuanxuepingzhaoyujinlixianpingzhangyulixiaojingyaochunyutangmiliuluzhaojunyingqiaoweicanggaoziqingchenlijun lacticaseibacillusrhamnosushm126alleviatesallergicrhinitisbymodulatingtheintestinalfloraandmetabolitesinmice |