Prognostic and clinicopathological role of soluble programmed cell death ligand-1 in patients with diffuse large B-cell lymphoma: a meta-analysis
BackgroundThe significance of soluble programmed death protein ligand-1 (PD-L1) in predicting the prognosis of diffuse large B-cell lymphoma (DLBCL) has been previously analyzed, but with conflicting results. This study investigated the effect of soluble PD-L1 (sPD-L1) expression on the prognosis of...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-01-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1506799/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832576317209444352 |
|---|---|
| author | Hongbin Lu Lulu Luo Jie Mi Min Sun Huaping Wang Zheng Wang Wenwen Ding |
| author_facet | Hongbin Lu Lulu Luo Jie Mi Min Sun Huaping Wang Zheng Wang Wenwen Ding |
| author_sort | Hongbin Lu |
| collection | DOAJ |
| description | BackgroundThe significance of soluble programmed death protein ligand-1 (PD-L1) in predicting the prognosis of diffuse large B-cell lymphoma (DLBCL) has been previously analyzed, but with conflicting results. This study investigated the effect of soluble PD-L1 (sPD-L1) expression on the prognosis of patients with DLBCL.MethodsWe comprehensively searched the Web of Science, PubMed, Embase, and CNKI databases between their inception and August 14, 2024. The value of sPD-L1 in predicting the overall survival (OS) and progression-free survival (PFS) of patients with DLBCL was analyzed by computing the combined hazard ratios (HRs) and 95% confidence intervals (CIs). Associations between sPD-L1 and the clinicopathological factors of DLBCL were explored by combining odds ratios (ORs) and 95%CIs.ResultsSeven articles involving 826 patients were included in this meta-analysis. Based on our pooled data, elevated sPD-L1 was closely related to poor OS (HR = 2.81, 95%CI = 1.99–3.95, p < 0.001) and inferior PFS (HR = 3.16, 95%CI = 1.41–7.08, p = 0.005) of DLBCL. Moreover, based on the pooled data, higher sPD-L1 was significantly related to the Eastern Cooperative Oncology Group Performance Status Scale (ECOG PS) ≥2 (OR=4.10, 95%CI=1.82-9.24, p=0.001), clinical stage III-IV (OR = 3.30, 95%CI = 1.48–7.39, p = 0.004), elevated lactate dehydrogenase (LDH) levels (OR = 2.14, 95%CI = 1.07–4.30, p = 0.032), and the International Prognostic Index (IPI) score 3–5 (OR = 3.83, 95%CI = 1.91–7.68, p < 0.001) in DLBCL.ConclusionAccording to our findings, a higher sPD-L1 level was a significant predictor of poor OS and PFS in patients with DLBCL. Elevated sPD-L1 levels are closely related to factors representing disease aggressiveness in DLBCL. |
| format | Article |
| id | doaj-art-0e8599e836c647419d765af567b714bd |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-0e8599e836c647419d765af567b714bd2025-01-31T06:40:12ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-01-011510.3389/fonc.2025.15067991506799Prognostic and clinicopathological role of soluble programmed cell death ligand-1 in patients with diffuse large B-cell lymphoma: a meta-analysisHongbin Lu0Lulu Luo1Jie Mi2Min Sun3Huaping Wang4Zheng Wang5Wenwen Ding6Department of Hematology, Wuxi Branch of Ruijin Hospital Shanghai Jiao Tong University School of Medicine, Wuxi, Jiangsu, ChinaDepartment of Hematology, Wuxi Branch of Ruijin Hospital Shanghai Jiao Tong University School of Medicine, Wuxi, Jiangsu, ChinaDepartment of Hematology, Wuxi Branch of Ruijin Hospital Shanghai Jiao Tong University School of Medicine, Wuxi, Jiangsu, ChinaDepartment of Hematology, Wuxi Branch of Ruijin Hospital Shanghai Jiao Tong University School of Medicine, Wuxi, Jiangsu, ChinaDepartment of Hematology, Wuxi Branch of Ruijin Hospital Shanghai Jiao Tong University School of Medicine, Wuxi, Jiangsu, ChinaSuzhou Jsuniwell Medical Laboratory, Suzhou, Jiangsu, ChinaDepartment of Oncology, Wuxi Branch of Ruijin Hospital Shanghai Jiao Tong University School of Medicine, Wuxi, Jiangsu, ChinaBackgroundThe significance of soluble programmed death protein ligand-1 (PD-L1) in predicting the prognosis of diffuse large B-cell lymphoma (DLBCL) has been previously analyzed, but with conflicting results. This study investigated the effect of soluble PD-L1 (sPD-L1) expression on the prognosis of patients with DLBCL.MethodsWe comprehensively searched the Web of Science, PubMed, Embase, and CNKI databases between their inception and August 14, 2024. The value of sPD-L1 in predicting the overall survival (OS) and progression-free survival (PFS) of patients with DLBCL was analyzed by computing the combined hazard ratios (HRs) and 95% confidence intervals (CIs). Associations between sPD-L1 and the clinicopathological factors of DLBCL were explored by combining odds ratios (ORs) and 95%CIs.ResultsSeven articles involving 826 patients were included in this meta-analysis. Based on our pooled data, elevated sPD-L1 was closely related to poor OS (HR = 2.81, 95%CI = 1.99–3.95, p < 0.001) and inferior PFS (HR = 3.16, 95%CI = 1.41–7.08, p = 0.005) of DLBCL. Moreover, based on the pooled data, higher sPD-L1 was significantly related to the Eastern Cooperative Oncology Group Performance Status Scale (ECOG PS) ≥2 (OR=4.10, 95%CI=1.82-9.24, p=0.001), clinical stage III-IV (OR = 3.30, 95%CI = 1.48–7.39, p = 0.004), elevated lactate dehydrogenase (LDH) levels (OR = 2.14, 95%CI = 1.07–4.30, p = 0.032), and the International Prognostic Index (IPI) score 3–5 (OR = 3.83, 95%CI = 1.91–7.68, p < 0.001) in DLBCL.ConclusionAccording to our findings, a higher sPD-L1 level was a significant predictor of poor OS and PFS in patients with DLBCL. Elevated sPD-L1 levels are closely related to factors representing disease aggressiveness in DLBCL.https://www.frontiersin.org/articles/10.3389/fonc.2025.1506799/fullPD-L1circulatingsurvivalbiomarkermeta-analysis |
| spellingShingle | Hongbin Lu Lulu Luo Jie Mi Min Sun Huaping Wang Zheng Wang Wenwen Ding Prognostic and clinicopathological role of soluble programmed cell death ligand-1 in patients with diffuse large B-cell lymphoma: a meta-analysis Frontiers in Oncology PD-L1 circulating survival biomarker meta-analysis |
| title | Prognostic and clinicopathological role of soluble programmed cell death ligand-1 in patients with diffuse large B-cell lymphoma: a meta-analysis |
| title_full | Prognostic and clinicopathological role of soluble programmed cell death ligand-1 in patients with diffuse large B-cell lymphoma: a meta-analysis |
| title_fullStr | Prognostic and clinicopathological role of soluble programmed cell death ligand-1 in patients with diffuse large B-cell lymphoma: a meta-analysis |
| title_full_unstemmed | Prognostic and clinicopathological role of soluble programmed cell death ligand-1 in patients with diffuse large B-cell lymphoma: a meta-analysis |
| title_short | Prognostic and clinicopathological role of soluble programmed cell death ligand-1 in patients with diffuse large B-cell lymphoma: a meta-analysis |
| title_sort | prognostic and clinicopathological role of soluble programmed cell death ligand 1 in patients with diffuse large b cell lymphoma a meta analysis |
| topic | PD-L1 circulating survival biomarker meta-analysis |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1506799/full |
| work_keys_str_mv | AT hongbinlu prognosticandclinicopathologicalroleofsolubleprogrammedcelldeathligand1inpatientswithdiffuselargebcelllymphomaametaanalysis AT lululuo prognosticandclinicopathologicalroleofsolubleprogrammedcelldeathligand1inpatientswithdiffuselargebcelllymphomaametaanalysis AT jiemi prognosticandclinicopathologicalroleofsolubleprogrammedcelldeathligand1inpatientswithdiffuselargebcelllymphomaametaanalysis AT minsun prognosticandclinicopathologicalroleofsolubleprogrammedcelldeathligand1inpatientswithdiffuselargebcelllymphomaametaanalysis AT huapingwang prognosticandclinicopathologicalroleofsolubleprogrammedcelldeathligand1inpatientswithdiffuselargebcelllymphomaametaanalysis AT zhengwang prognosticandclinicopathologicalroleofsolubleprogrammedcelldeathligand1inpatientswithdiffuselargebcelllymphomaametaanalysis AT wenwending prognosticandclinicopathologicalroleofsolubleprogrammedcelldeathligand1inpatientswithdiffuselargebcelllymphomaametaanalysis |