Mechanism of Histone Deacetylase Inhibitors for Treatment of Idiopathic Pulmonary Fibrosis
Idiopathic pulmonary fibrosis(IPF) is a chronic, progressive, and fibrotic interstitial lung disease. In recent years, with the in-depth study of the pathological mechanism of IPF, more and more drug treatment targets for IPF have been discovered. Studies have shown that the dysregulation of epigene...
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Editorial Office of Medical Journal of Peking Union Medical College Hospital
2025-02-01
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| Series: | Xiehe Yixue Zazhi |
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| Online Access: | https://xhyxzz.pumch.cn/article/doi/10.12290/xhyxzz.2024-0415 |
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| author | ZHOU Jia LI Long LIAO Jing |
| author_facet | ZHOU Jia LI Long LIAO Jing |
| author_sort | ZHOU Jia |
| collection | DOAJ |
| description | Idiopathic pulmonary fibrosis(IPF) is a chronic, progressive, and fibrotic interstitial lung disease. In recent years, with the in-depth study of the pathological mechanism of IPF, more and more drug treatment targets for IPF have been discovered. Studies have shown that the dysregulation of epigenetic modifications can induce the occurrence of various lung diseases such as chronic obstructive pulmonary disease, asthma, and IPF. Histone deacetylase(HDAC) is not only a key link in the epigenetic modification process but also a key mediator in the pathogenesis of IPF. HDAC is highly expressed in myofibroblasts and alveolar epithelial cells and can play an important role in the pathogenesis of IPF by regulating the heritable expression of genes related to lung inflammation, fibrosis, and apoptosis. This review elaborates on the potential mechanisms of HDAC inhibitors in IPF from aspects such as epithelial-mesenchymal transition, chronic pulmonary inflammatory response, apoptosis, and macrophage polarization, aiming to evaluate the possibility of HDAC inhibitors as targeted therapeutic drugs for IPF and provide certain reference for related research. |
| format | Article |
| id | doaj-art-0e8566e2317544c9b794fd7b13e69dbc |
| institution | Kabale University |
| issn | 1674-9081 |
| language | zho |
| publishDate | 2025-02-01 |
| publisher | Editorial Office of Medical Journal of Peking Union Medical College Hospital |
| record_format | Article |
| series | Xiehe Yixue Zazhi |
| spelling | doaj-art-0e8566e2317544c9b794fd7b13e69dbc2025-08-20T03:45:14ZzhoEditorial Office of Medical Journal of Peking Union Medical College HospitalXiehe Yixue Zazhi1674-90812025-02-0116498999410.12290/xhyxzz.2024-0415Mechanism of Histone Deacetylase Inhibitors for Treatment of Idiopathic Pulmonary FibrosisZHOU Jia0LI LongLIAO Jing1The First Clinical College of Medicine of Lanzhou University, Lanzhou 730000, ChinaThe First Clinical College of Medicine of Lanzhou University, Lanzhou 730000, ChinaIdiopathic pulmonary fibrosis(IPF) is a chronic, progressive, and fibrotic interstitial lung disease. In recent years, with the in-depth study of the pathological mechanism of IPF, more and more drug treatment targets for IPF have been discovered. Studies have shown that the dysregulation of epigenetic modifications can induce the occurrence of various lung diseases such as chronic obstructive pulmonary disease, asthma, and IPF. Histone deacetylase(HDAC) is not only a key link in the epigenetic modification process but also a key mediator in the pathogenesis of IPF. HDAC is highly expressed in myofibroblasts and alveolar epithelial cells and can play an important role in the pathogenesis of IPF by regulating the heritable expression of genes related to lung inflammation, fibrosis, and apoptosis. This review elaborates on the potential mechanisms of HDAC inhibitors in IPF from aspects such as epithelial-mesenchymal transition, chronic pulmonary inflammatory response, apoptosis, and macrophage polarization, aiming to evaluate the possibility of HDAC inhibitors as targeted therapeutic drugs for IPF and provide certain reference for related research.https://xhyxzz.pumch.cn/article/doi/10.12290/xhyxzz.2024-0415idiopathic pulmonary fibrosishistone deacetylaseepithelial-mesenchymal transitioninflammatory responseapoptosis |
| spellingShingle | ZHOU Jia LI Long LIAO Jing Mechanism of Histone Deacetylase Inhibitors for Treatment of Idiopathic Pulmonary Fibrosis Xiehe Yixue Zazhi idiopathic pulmonary fibrosis histone deacetylase epithelial-mesenchymal transition inflammatory response apoptosis |
| title | Mechanism of Histone Deacetylase Inhibitors for Treatment of Idiopathic Pulmonary Fibrosis |
| title_full | Mechanism of Histone Deacetylase Inhibitors for Treatment of Idiopathic Pulmonary Fibrosis |
| title_fullStr | Mechanism of Histone Deacetylase Inhibitors for Treatment of Idiopathic Pulmonary Fibrosis |
| title_full_unstemmed | Mechanism of Histone Deacetylase Inhibitors for Treatment of Idiopathic Pulmonary Fibrosis |
| title_short | Mechanism of Histone Deacetylase Inhibitors for Treatment of Idiopathic Pulmonary Fibrosis |
| title_sort | mechanism of histone deacetylase inhibitors for treatment of idiopathic pulmonary fibrosis |
| topic | idiopathic pulmonary fibrosis histone deacetylase epithelial-mesenchymal transition inflammatory response apoptosis |
| url | https://xhyxzz.pumch.cn/article/doi/10.12290/xhyxzz.2024-0415 |
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