Clinical and laboratory evaluation of Turkish children with IgG subclass deficiency
Background: IgG subclass deficiency is a laboratory diagnosis and becomes important with recurrent infections. This study aimed to examine the demographic, clinical, and laboratory results of pediatric cases with IgG subclass deficiency and to improve the understanding of the clinical significance o...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Pediatrics and Neonatology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1875957222001863 |
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| author | Mehmet Kocaoğlu Burcu Ezgi Kocaoğlu Selma Erol Aytekin Doğukan Mustafa Keskin Şükrü Nail Güner Sevgi Keleş İsmail Reisli |
| author_facet | Mehmet Kocaoğlu Burcu Ezgi Kocaoğlu Selma Erol Aytekin Doğukan Mustafa Keskin Şükrü Nail Güner Sevgi Keleş İsmail Reisli |
| author_sort | Mehmet Kocaoğlu |
| collection | DOAJ |
| description | Background: IgG subclass deficiency is a laboratory diagnosis and becomes important with recurrent infections. This study aimed to examine the demographic, clinical, and laboratory results of pediatric cases with IgG subclass deficiency and to improve the understanding of the clinical significance of IgG subclass deficiency. Methods: In this study, the clinical and laboratory features of 111 pediatric patients, with at least one whose serum IgG subclasses was measured as lower than 2 standard deviation of healthy aged-matched control values, were evaluated. The clinical and laboratory features of the cases with isolated IgG subclass deficiency (Group 1) and those with low serum levels of any of IgG, IgA, and IgM in addition to the IgG subclass deficiency (Group 2) were compared. Results: A total of 55 (49.54%) and 56 (50.45%) patients were included in Groups 1 and 2, respectively. Among our studied cases, 20 (18.1%) had a history of hospitalization in the neonatal period, 61 (54.95%) had at least one hospitalization due to infection, and 55 (49.54%) had a history of recurrent infection. The frequencies of these three conditions were statistically significantly higher in Group 2 (p < 0.05). The frequencies of infections in the last year in Groups 1 and 2 were 4.4 ± 1.2 and 5.4 ± 1.9, respectively (p < 0.05). As a result of recurrent infections, 43.24% (n = 48) of our patients received antibiotic prophylaxis, and 21.62% (n = 24) had immunoglobulin replacement therapy. Furthermore, the numbers of patients who needed these treatments were higher in Group 2 (p < 0.05). Conclusion: In cases with IgG subclass deficiencies, concomitant main-group immunoglobulin deficiencies may increase the number and severity of infections, leading to hospitalizations, antibiotic prophylaxis, and immunoglobulin therapy. More attention should be paid to cases of immunoglobulin main-group deficiencies in the follow-up of these cases. |
| format | Article |
| id | doaj-art-0e829ff5e77846c4a5239ae678d6eb9d |
| institution | Kabale University |
| issn | 1875-9572 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pediatrics and Neonatology |
| spelling | doaj-art-0e829ff5e77846c4a5239ae678d6eb9d2025-08-20T03:49:16ZengElsevierPediatrics and Neonatology1875-95722023-01-01641384510.1016/j.pedneo.2022.04.014Clinical and laboratory evaluation of Turkish children with IgG subclass deficiencyMehmet Kocaoğlu0Burcu Ezgi Kocaoğlu1Selma Erol Aytekin2Doğukan Mustafa Keskin3Şükrü Nail Güner4Sevgi Keleş5İsmail Reisli6Dr. Ali Kemal Belviranlı Obstetrics and Children’s Hospital, Konya, Turkey; Corresponding author.Department of Family Medicine, Konya City Hospital, Konya, TurkeyDepartment of Pediatric Immunology and Allergy, Necmettin Erbakan University Meram Medical Faculty, Konya, TurkeyDr. Ali Kemal Belviranlı Obstetrics and Children’s Hospital, Konya, TurkeyDepartment of Pediatric Immunology and Allergy, Necmettin Erbakan University Meram Medical Faculty, Konya, TurkeyDepartment of Pediatric Immunology and Allergy, Necmettin Erbakan University Meram Medical Faculty, Konya, TurkeyDepartment of Pediatric Immunology and Allergy, Necmettin Erbakan University Meram Medical Faculty, Konya, TurkeyBackground: IgG subclass deficiency is a laboratory diagnosis and becomes important with recurrent infections. This study aimed to examine the demographic, clinical, and laboratory results of pediatric cases with IgG subclass deficiency and to improve the understanding of the clinical significance of IgG subclass deficiency. Methods: In this study, the clinical and laboratory features of 111 pediatric patients, with at least one whose serum IgG subclasses was measured as lower than 2 standard deviation of healthy aged-matched control values, were evaluated. The clinical and laboratory features of the cases with isolated IgG subclass deficiency (Group 1) and those with low serum levels of any of IgG, IgA, and IgM in addition to the IgG subclass deficiency (Group 2) were compared. Results: A total of 55 (49.54%) and 56 (50.45%) patients were included in Groups 1 and 2, respectively. Among our studied cases, 20 (18.1%) had a history of hospitalization in the neonatal period, 61 (54.95%) had at least one hospitalization due to infection, and 55 (49.54%) had a history of recurrent infection. The frequencies of these three conditions were statistically significantly higher in Group 2 (p < 0.05). The frequencies of infections in the last year in Groups 1 and 2 were 4.4 ± 1.2 and 5.4 ± 1.9, respectively (p < 0.05). As a result of recurrent infections, 43.24% (n = 48) of our patients received antibiotic prophylaxis, and 21.62% (n = 24) had immunoglobulin replacement therapy. Furthermore, the numbers of patients who needed these treatments were higher in Group 2 (p < 0.05). Conclusion: In cases with IgG subclass deficiencies, concomitant main-group immunoglobulin deficiencies may increase the number and severity of infections, leading to hospitalizations, antibiotic prophylaxis, and immunoglobulin therapy. More attention should be paid to cases of immunoglobulin main-group deficiencies in the follow-up of these cases.http://www.sciencedirect.com/science/article/pii/S1875957222001863antibody deficiencychildIgG subclass deficiency |
| spellingShingle | Mehmet Kocaoğlu Burcu Ezgi Kocaoğlu Selma Erol Aytekin Doğukan Mustafa Keskin Şükrü Nail Güner Sevgi Keleş İsmail Reisli Clinical and laboratory evaluation of Turkish children with IgG subclass deficiency Pediatrics and Neonatology antibody deficiency child IgG subclass deficiency |
| title | Clinical and laboratory evaluation of Turkish children with IgG subclass deficiency |
| title_full | Clinical and laboratory evaluation of Turkish children with IgG subclass deficiency |
| title_fullStr | Clinical and laboratory evaluation of Turkish children with IgG subclass deficiency |
| title_full_unstemmed | Clinical and laboratory evaluation of Turkish children with IgG subclass deficiency |
| title_short | Clinical and laboratory evaluation of Turkish children with IgG subclass deficiency |
| title_sort | clinical and laboratory evaluation of turkish children with igg subclass deficiency |
| topic | antibody deficiency child IgG subclass deficiency |
| url | http://www.sciencedirect.com/science/article/pii/S1875957222001863 |
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