Bisphenol A in Chronic Kidney Disease
Phenols are uremic toxins of intestinal origin formed by bacteria during protein metabolism. Of these molecules, p-cresol is the most studied and has been associated with renal function impairment and vascular damage. Bisphenol A (BPA) is a molecule with structural similarity with phenols found in p...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
|
| Series: | International Journal of Nephrology |
| Online Access: | http://dx.doi.org/10.1155/2013/437857 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832550675327746048 |
|---|---|
| author | Emilio González-Parra Jose Antonio Herrero Usama Elewa Ricardo J. Bosch Alberto Ortiz Arduán Jesus Egido |
| author_facet | Emilio González-Parra Jose Antonio Herrero Usama Elewa Ricardo J. Bosch Alberto Ortiz Arduán Jesus Egido |
| author_sort | Emilio González-Parra |
| collection | DOAJ |
| description | Phenols are uremic toxins of intestinal origin formed by bacteria during protein metabolism. Of these molecules, p-cresol is the most studied and has been associated with renal function impairment and vascular damage. Bisphenol A (BPA) is a molecule with structural similarity with phenols found in plastic food and beverage containers as well as in some dialyzers. BPA is considered an environmental toxicant based on animal and cell culture studies. Japanese authorities recently banned BPA use in baby bottles based on observational association studies in newborns. BPA is excreted in urine and uremic patients present higher serum levels, but there is insufficient evidence to set cut-off levels or to link BPA to any harmful effect in CKD. However, the renal elimination and potential exposure during dialysis warrant the monitoring of BPA exposure and the design of observational studies in which the potential health risks of BPA for end-stage renal disease patients are evaluated. |
| format | Article |
| id | doaj-art-0e7da2ceec694aa39079c10a758ea8c2 |
| institution | Kabale University |
| issn | 2090-214X 2090-2158 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Nephrology |
| spelling | doaj-art-0e7da2ceec694aa39079c10a758ea8c22025-02-03T06:06:05ZengWileyInternational Journal of Nephrology2090-214X2090-21582013-01-01201310.1155/2013/437857437857Bisphenol A in Chronic Kidney DiseaseEmilio González-Parra0Jose Antonio Herrero1Usama Elewa2Ricardo J. Bosch3Alberto Ortiz Arduán4Jesus Egido5Servicio de Nefrología, IIS-Fundación Jiménez Díaz and IRSIN, Madrid, SpainServicio de Nefrología, Hospital Clínico San Carlos, Profesor Martín Lagos s/n, 28040 Madrid, SpainServicio de Nefrología, IIS-Fundación Jiménez Díaz and IRSIN, Madrid, SpainLaboratorio de Fisiología Renal y Nefrología Experimental, Departamento de Fisiología, Universidad de Alcalá, Madrid, SpainServicio de Nefrología, IIS-Fundación Jiménez Díaz and IRSIN, Madrid, SpainServicio de Nefrología, IIS-Fundación Jiménez Díaz and IRSIN, Madrid, SpainPhenols are uremic toxins of intestinal origin formed by bacteria during protein metabolism. Of these molecules, p-cresol is the most studied and has been associated with renal function impairment and vascular damage. Bisphenol A (BPA) is a molecule with structural similarity with phenols found in plastic food and beverage containers as well as in some dialyzers. BPA is considered an environmental toxicant based on animal and cell culture studies. Japanese authorities recently banned BPA use in baby bottles based on observational association studies in newborns. BPA is excreted in urine and uremic patients present higher serum levels, but there is insufficient evidence to set cut-off levels or to link BPA to any harmful effect in CKD. However, the renal elimination and potential exposure during dialysis warrant the monitoring of BPA exposure and the design of observational studies in which the potential health risks of BPA for end-stage renal disease patients are evaluated.http://dx.doi.org/10.1155/2013/437857 |
| spellingShingle | Emilio González-Parra Jose Antonio Herrero Usama Elewa Ricardo J. Bosch Alberto Ortiz Arduán Jesus Egido Bisphenol A in Chronic Kidney Disease International Journal of Nephrology |
| title | Bisphenol A in Chronic Kidney Disease |
| title_full | Bisphenol A in Chronic Kidney Disease |
| title_fullStr | Bisphenol A in Chronic Kidney Disease |
| title_full_unstemmed | Bisphenol A in Chronic Kidney Disease |
| title_short | Bisphenol A in Chronic Kidney Disease |
| title_sort | bisphenol a in chronic kidney disease |
| url | http://dx.doi.org/10.1155/2013/437857 |
| work_keys_str_mv | AT emiliogonzalezparra bisphenolainchronickidneydisease AT joseantonioherrero bisphenolainchronickidneydisease AT usamaelewa bisphenolainchronickidneydisease AT ricardojbosch bisphenolainchronickidneydisease AT albertoortizarduan bisphenolainchronickidneydisease AT jesusegido bisphenolainchronickidneydisease |