Rauwolfia vomitoria- a promising medical plant for benign prostatic hyperplasia management; yet with challenges
Background: Benign Prostatic Hyperplasia (BPH) is a common condition among aging men. This condition often leads to a reduced quality of life due to its debilitating symptoms. Although conventional allopathic treatments are widely used for managing BPH, they are frequently associated with adverse si...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Phytomedicine Plus |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667031325000120 |
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| author | George Awuku Asare Perpetua Dagadu Samuel Adjei Bernice Asiedu Samkeliso Takaidza Vivash Naidoo Brodrick Amoah Ifeoma Celestina Orabueze Kwasi Bugyei |
| author_facet | George Awuku Asare Perpetua Dagadu Samuel Adjei Bernice Asiedu Samkeliso Takaidza Vivash Naidoo Brodrick Amoah Ifeoma Celestina Orabueze Kwasi Bugyei |
| author_sort | George Awuku Asare |
| collection | DOAJ |
| description | Background: Benign Prostatic Hyperplasia (BPH) is a common condition among aging men. This condition often leads to a reduced quality of life due to its debilitating symptoms. Although conventional allopathic treatments are widely used for managing BPH, they are frequently associated with adverse side effects, prompting a global shift toward natural and alternative therapies. This study aims to investigate the therapeutic effects of Rauwolfia vomitoria Aqueous Root Extract (RVARE) as a potential natural oral treatment for BPH. Methodology: Six groups of male Sprague-Dawley rats were established [N = 7/group]. Group 1 comprised of normal rats whilst group 2 to group 6 comprised of BPH induced rats. Group 1: Control group- received normal chow diet. Group 2: Model group- [no treatment]. Group 3: received 10 mg/kg. b. wt. RVARE. Group 4: received 25 mg/kg. b.wt. RVARE. Group 5: received 50 mg/kg. b.wt, RVARE. Group 6: served as a positive control [Finasteride]. The study was carried out for 28 days. Upon termination, blood was sampled for general biochemical, haematological and PSA determination. Systemic organs and the prostate were harvested for histological analyses. Result: Histopathological analysis of the liver of RVARE treated groups demonstrated alterations. Additionally, a reduction in relative prostate weight compared to the model group was observed, though not statistically significant (p > 0.05). However, a significant reduction in prostate specific antigen (PSA) levels was seen in the RVARE-treated groups (Model vs Gp 3, p = 0.001; Model vs Gp 4, p = 0.000; Model vs Gp 5, p = 0.001). Conclusion: RVARE appears to be effective in reducing prostate size and PSA levels. However, its hepatotoxic effect needs further investigation. |
| format | Article |
| id | doaj-art-0e73f1515ceb4e1db22f15c0c94b1aa6 |
| institution | Kabale University |
| issn | 2667-0313 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Phytomedicine Plus |
| spelling | doaj-art-0e73f1515ceb4e1db22f15c0c94b1aa62025-02-10T04:35:22ZengElsevierPhytomedicine Plus2667-03132025-02-0151100739Rauwolfia vomitoria- a promising medical plant for benign prostatic hyperplasia management; yet with challengesGeorge Awuku Asare0Perpetua Dagadu1Samuel Adjei2Bernice Asiedu3Samkeliso Takaidza4Vivash Naidoo5Brodrick Amoah6Ifeoma Celestina Orabueze7Kwasi Bugyei8University of Ghana School of Biomedical and Allied Health Sciences, Department of Medical Laboratory Sciences, Ghana; Corresponding authors.University of Ghana Medical School, Department of Pharmacology and Toxicology, GhanaUniversity of Ghana Noguchi Memorial Institute for Medical Research (NMIMR), Department of Animal Experimentation, Ghana; Corresponding authors.University of Ghana School of Biomedical and Allied Health Sciences, Department of Medical Laboratory Sciences, GhanaVaal University of Technology, Department of Natural Sciences, GhanaUniversity of the Witwatersrand, Department of Family Medicine, GhanaUniversity of Ghana School of Biomedical and Allied Health Sciences, Department of Medical Laboratory Sciences, GhanaUniversity of Lagos, Department of Pharmacognosy, NigeriaUniversity of Ghana Medical School, Department of Pharmacology and Toxicology, GhanaBackground: Benign Prostatic Hyperplasia (BPH) is a common condition among aging men. This condition often leads to a reduced quality of life due to its debilitating symptoms. Although conventional allopathic treatments are widely used for managing BPH, they are frequently associated with adverse side effects, prompting a global shift toward natural and alternative therapies. This study aims to investigate the therapeutic effects of Rauwolfia vomitoria Aqueous Root Extract (RVARE) as a potential natural oral treatment for BPH. Methodology: Six groups of male Sprague-Dawley rats were established [N = 7/group]. Group 1 comprised of normal rats whilst group 2 to group 6 comprised of BPH induced rats. Group 1: Control group- received normal chow diet. Group 2: Model group- [no treatment]. Group 3: received 10 mg/kg. b. wt. RVARE. Group 4: received 25 mg/kg. b.wt. RVARE. Group 5: received 50 mg/kg. b.wt, RVARE. Group 6: served as a positive control [Finasteride]. The study was carried out for 28 days. Upon termination, blood was sampled for general biochemical, haematological and PSA determination. Systemic organs and the prostate were harvested for histological analyses. Result: Histopathological analysis of the liver of RVARE treated groups demonstrated alterations. Additionally, a reduction in relative prostate weight compared to the model group was observed, though not statistically significant (p > 0.05). However, a significant reduction in prostate specific antigen (PSA) levels was seen in the RVARE-treated groups (Model vs Gp 3, p = 0.001; Model vs Gp 4, p = 0.000; Model vs Gp 5, p = 0.001). Conclusion: RVARE appears to be effective in reducing prostate size and PSA levels. However, its hepatotoxic effect needs further investigation.http://www.sciencedirect.com/science/article/pii/S2667031325000120Rauwolfia vomitoriaBenign prostatic hyperplasiaSafety |
| spellingShingle | George Awuku Asare Perpetua Dagadu Samuel Adjei Bernice Asiedu Samkeliso Takaidza Vivash Naidoo Brodrick Amoah Ifeoma Celestina Orabueze Kwasi Bugyei Rauwolfia vomitoria- a promising medical plant for benign prostatic hyperplasia management; yet with challenges Phytomedicine Plus Rauwolfia vomitoria Benign prostatic hyperplasia Safety |
| title | Rauwolfia vomitoria- a promising medical plant for benign prostatic hyperplasia management; yet with challenges |
| title_full | Rauwolfia vomitoria- a promising medical plant for benign prostatic hyperplasia management; yet with challenges |
| title_fullStr | Rauwolfia vomitoria- a promising medical plant for benign prostatic hyperplasia management; yet with challenges |
| title_full_unstemmed | Rauwolfia vomitoria- a promising medical plant for benign prostatic hyperplasia management; yet with challenges |
| title_short | Rauwolfia vomitoria- a promising medical plant for benign prostatic hyperplasia management; yet with challenges |
| title_sort | rauwolfia vomitoria a promising medical plant for benign prostatic hyperplasia management yet with challenges |
| topic | Rauwolfia vomitoria Benign prostatic hyperplasia Safety |
| url | http://www.sciencedirect.com/science/article/pii/S2667031325000120 |
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