Influence of Body Composition on the Perioperative and Survival Outcomes of Renal Cell Carcinoma
The purpose of this review is to provide an up-to-date understanding of the literature describing the impact of body composition on renal cell carcinoma (RCC) prognosis and outcomes. Although obesity is recognized as a risk factor for RCC development, overweight patients with localized and advanced...
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| Format: | Article |
| Language: | English |
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Korean Urological Oncology Society
2023-11-01
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| Series: | Journal of Urologic Oncology |
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| Online Access: | http://www.e-juo.org/upload/pdf/juo-21-3-183.pdf |
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| author | Edouard H. Nicaise Benjamin N. Schmeusser Yash B. Shah Mehmet A. Bilen Kenneth Ogan Viraj A. Master |
| author_facet | Edouard H. Nicaise Benjamin N. Schmeusser Yash B. Shah Mehmet A. Bilen Kenneth Ogan Viraj A. Master |
| author_sort | Edouard H. Nicaise |
| collection | DOAJ |
| description | The purpose of this review is to provide an up-to-date understanding of the literature describing the impact of body composition on renal cell carcinoma (RCC) prognosis and outcomes. Although obesity is recognized as a risk factor for RCC development, overweight patients with localized and advanced RCC display more favorable outcomes than normal-weight individuals. However, obesity as measured by body mass index is a poor indicator of total body fat, fails to account for lean muscle mass, and inconsistently predicts perioperative and survival outcomes in RCC. Recent studies have suggested that objective measurements of lean and fat body masses from various compartments have strong prognostic utility. Low muscle mass (i.e., sarcopenia) and low visceral adiposity are often associated with poorer survival outcomes in localized and advanced RCC. These patients tend to experience higher rates of recurrence, progression, treatment failure, and death from kidney cancer. Given the influence of body composition in RCC outcomes, further characterization of the role of prehabilitation programs is warranted to evaluate the feasibility and efficacy of interventions targeting these modifiable factors. |
| format | Article |
| id | doaj-art-0e6e559c52b54877bee2b55ac948b26e |
| institution | DOAJ |
| issn | 2951-603X 2982-7043 |
| language | English |
| publishDate | 2023-11-01 |
| publisher | Korean Urological Oncology Society |
| record_format | Article |
| series | Journal of Urologic Oncology |
| spelling | doaj-art-0e6e559c52b54877bee2b55ac948b26e2025-08-20T02:51:31ZengKorean Urological Oncology SocietyJournal of Urologic Oncology2951-603X2982-70432023-11-0121318319910.22465/juo.234600500025553Influence of Body Composition on the Perioperative and Survival Outcomes of Renal Cell CarcinomaEdouard H. Nicaise0Benjamin N. Schmeusser1Yash B. Shah2Mehmet A. Bilen3Kenneth Ogan4Viraj A. Master5 Department of Urology, Emory University School of Medicine, Atlanta, GA, USA Department of Urology, Indiana University School of Medicine, Indianapolis, IN, USA Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA Department of Urology, Emory University School of Medicine, Atlanta, GA, USA Department of Urology, Emory University School of Medicine, Atlanta, GA, USAThe purpose of this review is to provide an up-to-date understanding of the literature describing the impact of body composition on renal cell carcinoma (RCC) prognosis and outcomes. Although obesity is recognized as a risk factor for RCC development, overweight patients with localized and advanced RCC display more favorable outcomes than normal-weight individuals. However, obesity as measured by body mass index is a poor indicator of total body fat, fails to account for lean muscle mass, and inconsistently predicts perioperative and survival outcomes in RCC. Recent studies have suggested that objective measurements of lean and fat body masses from various compartments have strong prognostic utility. Low muscle mass (i.e., sarcopenia) and low visceral adiposity are often associated with poorer survival outcomes in localized and advanced RCC. These patients tend to experience higher rates of recurrence, progression, treatment failure, and death from kidney cancer. Given the influence of body composition in RCC outcomes, further characterization of the role of prehabilitation programs is warranted to evaluate the feasibility and efficacy of interventions targeting these modifiable factors.http://www.e-juo.org/upload/pdf/juo-21-3-183.pdfrenal cell carcinomabody compositionbody mass indexsarcopeniaadipositysurvival |
| spellingShingle | Edouard H. Nicaise Benjamin N. Schmeusser Yash B. Shah Mehmet A. Bilen Kenneth Ogan Viraj A. Master Influence of Body Composition on the Perioperative and Survival Outcomes of Renal Cell Carcinoma Journal of Urologic Oncology renal cell carcinoma body composition body mass index sarcopenia adiposity survival |
| title | Influence of Body Composition on the Perioperative and Survival Outcomes of Renal Cell Carcinoma |
| title_full | Influence of Body Composition on the Perioperative and Survival Outcomes of Renal Cell Carcinoma |
| title_fullStr | Influence of Body Composition on the Perioperative and Survival Outcomes of Renal Cell Carcinoma |
| title_full_unstemmed | Influence of Body Composition on the Perioperative and Survival Outcomes of Renal Cell Carcinoma |
| title_short | Influence of Body Composition on the Perioperative and Survival Outcomes of Renal Cell Carcinoma |
| title_sort | influence of body composition on the perioperative and survival outcomes of renal cell carcinoma |
| topic | renal cell carcinoma body composition body mass index sarcopenia adiposity survival |
| url | http://www.e-juo.org/upload/pdf/juo-21-3-183.pdf |
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