A Case of Pyoderma Gangrenosum Misdiagnosed as Necrotizing Infection: A Potential Diagnostic Catastrophe
In this article, we present a case of pyoderma gangrenosum (PG), misdiagnosed initially as a necrotizing infection that significantly worsened due to repeated surgical debridement and aggressive wound care therapy, almost resulting in limb amputation despite antibiotic therapy. The PG lesions improv...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2018-01-01
|
| Series: | Case Reports in Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/2018/8907542 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849703330285092864 |
|---|---|
| author | Medina G. Saffie Anjali Shroff |
| author_facet | Medina G. Saffie Anjali Shroff |
| author_sort | Medina G. Saffie |
| collection | DOAJ |
| description | In this article, we present a case of pyoderma gangrenosum (PG), misdiagnosed initially as a necrotizing infection that significantly worsened due to repeated surgical debridement and aggressive wound care therapy, almost resulting in limb amputation despite antibiotic therapy. The PG lesions improved after pancytopenia were further investigated, and the diagnosis and treatment of an underlying hematologic malignancy was initiated. The diagnosis and management of PG is challenging given the paucity of robust clinical evidence, lack of standard diagnostic criteria, and absence of clinical practice guidelines. It is imperative that clinicians recognize PG as a clinical diagnosis that must be considered in any patient with enlarging, sterile, necrotic lesions that are unresponsive to prolonged and appropriate antibiotics. Early recognition can prevent devastating sequelae such as deep tissue and bone infections associated with a chronic open wound, severe cosmetic morbidity, and potential limb amputation. |
| format | Article |
| id | doaj-art-0e6db7bf95354d7e918fada08eee562b |
| institution | DOAJ |
| issn | 2090-6625 2090-6633 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Infectious Diseases |
| spelling | doaj-art-0e6db7bf95354d7e918fada08eee562b2025-08-20T03:17:19ZengWileyCase Reports in Infectious Diseases2090-66252090-66332018-01-01201810.1155/2018/89075428907542A Case of Pyoderma Gangrenosum Misdiagnosed as Necrotizing Infection: A Potential Diagnostic CatastropheMedina G. Saffie0Anjali Shroff1Department of Infectious Diseases Post Graduate Training Program, McMaster University, Hamilton, ON, CanadaDepartment of Infectious Diseases, McMaster University, Hamilton, ON, CanadaIn this article, we present a case of pyoderma gangrenosum (PG), misdiagnosed initially as a necrotizing infection that significantly worsened due to repeated surgical debridement and aggressive wound care therapy, almost resulting in limb amputation despite antibiotic therapy. The PG lesions improved after pancytopenia were further investigated, and the diagnosis and treatment of an underlying hematologic malignancy was initiated. The diagnosis and management of PG is challenging given the paucity of robust clinical evidence, lack of standard diagnostic criteria, and absence of clinical practice guidelines. It is imperative that clinicians recognize PG as a clinical diagnosis that must be considered in any patient with enlarging, sterile, necrotic lesions that are unresponsive to prolonged and appropriate antibiotics. Early recognition can prevent devastating sequelae such as deep tissue and bone infections associated with a chronic open wound, severe cosmetic morbidity, and potential limb amputation.http://dx.doi.org/10.1155/2018/8907542 |
| spellingShingle | Medina G. Saffie Anjali Shroff A Case of Pyoderma Gangrenosum Misdiagnosed as Necrotizing Infection: A Potential Diagnostic Catastrophe Case Reports in Infectious Diseases |
| title | A Case of Pyoderma Gangrenosum Misdiagnosed as Necrotizing Infection: A Potential Diagnostic Catastrophe |
| title_full | A Case of Pyoderma Gangrenosum Misdiagnosed as Necrotizing Infection: A Potential Diagnostic Catastrophe |
| title_fullStr | A Case of Pyoderma Gangrenosum Misdiagnosed as Necrotizing Infection: A Potential Diagnostic Catastrophe |
| title_full_unstemmed | A Case of Pyoderma Gangrenosum Misdiagnosed as Necrotizing Infection: A Potential Diagnostic Catastrophe |
| title_short | A Case of Pyoderma Gangrenosum Misdiagnosed as Necrotizing Infection: A Potential Diagnostic Catastrophe |
| title_sort | case of pyoderma gangrenosum misdiagnosed as necrotizing infection a potential diagnostic catastrophe |
| url | http://dx.doi.org/10.1155/2018/8907542 |
| work_keys_str_mv | AT medinagsaffie acaseofpyodermagangrenosummisdiagnosedasnecrotizinginfectionapotentialdiagnosticcatastrophe AT anjalishroff acaseofpyodermagangrenosummisdiagnosedasnecrotizinginfectionapotentialdiagnosticcatastrophe AT medinagsaffie caseofpyodermagangrenosummisdiagnosedasnecrotizinginfectionapotentialdiagnosticcatastrophe AT anjalishroff caseofpyodermagangrenosummisdiagnosedasnecrotizinginfectionapotentialdiagnosticcatastrophe |