Well-Differentiated Liposarcoma That Increased in Size after Menopause: A Case Report and a Review of the Literature
This study reports a case of uterine liposarcoma together with a literature review. At 52 years old, our patient was diagnosed with lipoleiomyoma by MRI. A mass (39×32×41 mm3) protruding from the anterior wall of the uterine body was observed. When the patient was 58, her previous doctor found that...
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| Format: | Article |
| Language: | English |
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Wiley
2024-01-01
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| Series: | Case Reports in Obstetrics and Gynecology |
| Online Access: | http://dx.doi.org/10.1155/2024/7599714 |
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| author | Tatsuji Hoshino Yoshihiro Takada Ayako Sugihara Masato Kinugasa Yoshiyuki Tsuji |
| author_facet | Tatsuji Hoshino Yoshihiro Takada Ayako Sugihara Masato Kinugasa Yoshiyuki Tsuji |
| author_sort | Tatsuji Hoshino |
| collection | DOAJ |
| description | This study reports a case of uterine liposarcoma together with a literature review. At 52 years old, our patient was diagnosed with lipoleiomyoma by MRI. A mass (39×32×41 mm3) protruding from the anterior wall of the uterine body was observed. When the patient was 58, her previous doctor found that the tumor had grown, and she was referred to the gynecology department of our hospital. On MRI, the major diameter was 1.23-fold longer and the volume was 1.85-fold higher compared with the prior imaging findings. Diffusion-weighted images revealed no significant anomalous signals. Thus, malignant tumors were included in the differential diagnosis. The patient consented to total abdominal hysterectomy and bilateral salpingo-oophorectomy. The mass on the anterior wall remained completely in the myometrium. No implantation was found in the abdominal cavity, and ascites was not detected. No bleeding or necrosis was observed on the cut surface. Histopathologically, differences in the sizes of adipocytes and stromal cells were identified. There were irregularities in the nuclear findings. The immunohistochemical findings were as follows: CDK4 (+), desmin (+), S100p (−), and Ki−67=1%. Therefore, a diagnosis of well-differentiated liposarcoma was rendered. The lesion was localized in the uterus, and it was completely removed during surgery. Well-differentiated liposarcoma of uterine primary has no possibility of recurrence following complete resection, and thus, the patient underwent follow-up without additional treatment. No metastasis or recurrence has been observed for 10 months after surgery. |
| format | Article |
| id | doaj-art-0e6a4e268c0f41b4bb2e01426dc92a05 |
| institution | Kabale University |
| issn | 2090-6692 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Obstetrics and Gynecology |
| spelling | doaj-art-0e6a4e268c0f41b4bb2e01426dc92a052025-08-20T03:54:29ZengWileyCase Reports in Obstetrics and Gynecology2090-66922024-01-01202410.1155/2024/7599714Well-Differentiated Liposarcoma That Increased in Size after Menopause: A Case Report and a Review of the LiteratureTatsuji Hoshino0Yoshihiro Takada1Ayako Sugihara2Masato Kinugasa3Yoshiyuki Tsuji4Department of Obstetrics and GynecologyDepartment of RadiologyDepartment of PathologyDepartment of Obstetrics and GynecologyDepartment of Obstetrics and GynecologyThis study reports a case of uterine liposarcoma together with a literature review. At 52 years old, our patient was diagnosed with lipoleiomyoma by MRI. A mass (39×32×41 mm3) protruding from the anterior wall of the uterine body was observed. When the patient was 58, her previous doctor found that the tumor had grown, and she was referred to the gynecology department of our hospital. On MRI, the major diameter was 1.23-fold longer and the volume was 1.85-fold higher compared with the prior imaging findings. Diffusion-weighted images revealed no significant anomalous signals. Thus, malignant tumors were included in the differential diagnosis. The patient consented to total abdominal hysterectomy and bilateral salpingo-oophorectomy. The mass on the anterior wall remained completely in the myometrium. No implantation was found in the abdominal cavity, and ascites was not detected. No bleeding or necrosis was observed on the cut surface. Histopathologically, differences in the sizes of adipocytes and stromal cells were identified. There were irregularities in the nuclear findings. The immunohistochemical findings were as follows: CDK4 (+), desmin (+), S100p (−), and Ki−67=1%. Therefore, a diagnosis of well-differentiated liposarcoma was rendered. The lesion was localized in the uterus, and it was completely removed during surgery. Well-differentiated liposarcoma of uterine primary has no possibility of recurrence following complete resection, and thus, the patient underwent follow-up without additional treatment. No metastasis or recurrence has been observed for 10 months after surgery.http://dx.doi.org/10.1155/2024/7599714 |
| spellingShingle | Tatsuji Hoshino Yoshihiro Takada Ayako Sugihara Masato Kinugasa Yoshiyuki Tsuji Well-Differentiated Liposarcoma That Increased in Size after Menopause: A Case Report and a Review of the Literature Case Reports in Obstetrics and Gynecology |
| title | Well-Differentiated Liposarcoma That Increased in Size after Menopause: A Case Report and a Review of the Literature |
| title_full | Well-Differentiated Liposarcoma That Increased in Size after Menopause: A Case Report and a Review of the Literature |
| title_fullStr | Well-Differentiated Liposarcoma That Increased in Size after Menopause: A Case Report and a Review of the Literature |
| title_full_unstemmed | Well-Differentiated Liposarcoma That Increased in Size after Menopause: A Case Report and a Review of the Literature |
| title_short | Well-Differentiated Liposarcoma That Increased in Size after Menopause: A Case Report and a Review of the Literature |
| title_sort | well differentiated liposarcoma that increased in size after menopause a case report and a review of the literature |
| url | http://dx.doi.org/10.1155/2024/7599714 |
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