Choice of Cell Source in Cell-Based Therapies for Retinal Damage due to Age-Related Macular Degeneration: A Review
Background. Age-related macular degeneration (AMD) is a complex disorder that affects primarily the macula involving the retinal pigment epithelium (RPE) but also to a certain extent the photoreceptor layer and the retinal neurons. Cell transplantation is a promising option for AMD and clinical tria...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2013/465169 |
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| author | Sudhakar John Sundaram Natarajan Periyasamy Parikumar Mahesh Shanmugam P Rajappa Senthilkumar David William Green Samuel J. K. Abraham |
| author_facet | Sudhakar John Sundaram Natarajan Periyasamy Parikumar Mahesh Shanmugam P Rajappa Senthilkumar David William Green Samuel J. K. Abraham |
| author_sort | Sudhakar John |
| collection | DOAJ |
| description | Background. Age-related macular degeneration (AMD) is a complex disorder that affects primarily the macula involving the retinal pigment epithelium (RPE) but also to a certain extent the photoreceptor layer and the retinal neurons. Cell transplantation is a promising option for AMD and clinical trials are underway using different cell types. Methods. We hypothesize that instead of focusing on a particular cell source for concurrent regeneration of all the retinal layers and also to prevent exhaustive research on an array of cell sources for regeneration of each layer, the choice should depend on, precisely, which layer is damaged. Results. Thus, for a damage limited to the retinal pigment epithelial (RPE) layer, the choice we suggest would be RPE cells. When the damage extends to rods and cones, the choice would be bone marrow stem cells and when retinal neurons are involved, relatively immature stem cell populations with an inherent capacity to yield neuronal lineage such as hematopoietic stem cells, embryonic stem cells, or induced pluripotent stem cells can be tried. Conclusion. This short review will prove to be a valuable guideline for those working on cell therapy for AMD to plan their future directions of research and therapy for this condition. |
| format | Article |
| id | doaj-art-0e60bbe9602e43d3a8ccbe5cfb75c64c |
| institution | OA Journals |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-0e60bbe9602e43d3a8ccbe5cfb75c64c2025-08-20T02:02:25ZengWileyJournal of Ophthalmology2090-004X2090-00582013-01-01201310.1155/2013/465169465169Choice of Cell Source in Cell-Based Therapies for Retinal Damage due to Age-Related Macular Degeneration: A ReviewSudhakar John0Sundaram Natarajan1Periyasamy Parikumar2Mahesh Shanmugam P3Rajappa Senthilkumar4David William Green5Samuel J. K. Abraham6The Mary-Yoshio Translational Hexagon (MYTH), Nichi-In Centre for Regenerative Medicine (NCRM), P.O. Box 1262, Nungambakkam, Chennai 600034, IndiaAditya Jyot Eye Hospital, Plot No. 153, Road No. 9, Major Parmeshwaran Road, Opp S.I.W.S. College Gate No. 3, Wadala, Mumbai 400 031, IndiaThe Light Eye Hospital, No. 39 D, By Pass Road, Dharmapuri Ho, Dharmapuri, Tamil Nadu 636701, IndiaSankara Eye Hospital, Varthur Main Road, Marthahalli, Kundalahalli Gate, Bangalore 560037, IndiaThe Mary-Yoshio Translational Hexagon (MYTH), Nichi-In Centre for Regenerative Medicine (NCRM), P.O. Box 1262, Nungambakkam, Chennai 600034, IndiaFaculty of Dentistry, The University of Hong Kong, Pokfulam, Hong KongThe Mary-Yoshio Translational Hexagon (MYTH), Nichi-In Centre for Regenerative Medicine (NCRM), P.O. Box 1262, Nungambakkam, Chennai 600034, IndiaBackground. Age-related macular degeneration (AMD) is a complex disorder that affects primarily the macula involving the retinal pigment epithelium (RPE) but also to a certain extent the photoreceptor layer and the retinal neurons. Cell transplantation is a promising option for AMD and clinical trials are underway using different cell types. Methods. We hypothesize that instead of focusing on a particular cell source for concurrent regeneration of all the retinal layers and also to prevent exhaustive research on an array of cell sources for regeneration of each layer, the choice should depend on, precisely, which layer is damaged. Results. Thus, for a damage limited to the retinal pigment epithelial (RPE) layer, the choice we suggest would be RPE cells. When the damage extends to rods and cones, the choice would be bone marrow stem cells and when retinal neurons are involved, relatively immature stem cell populations with an inherent capacity to yield neuronal lineage such as hematopoietic stem cells, embryonic stem cells, or induced pluripotent stem cells can be tried. Conclusion. This short review will prove to be a valuable guideline for those working on cell therapy for AMD to plan their future directions of research and therapy for this condition.http://dx.doi.org/10.1155/2013/465169 |
| spellingShingle | Sudhakar John Sundaram Natarajan Periyasamy Parikumar Mahesh Shanmugam P Rajappa Senthilkumar David William Green Samuel J. K. Abraham Choice of Cell Source in Cell-Based Therapies for Retinal Damage due to Age-Related Macular Degeneration: A Review Journal of Ophthalmology |
| title | Choice of Cell Source in Cell-Based Therapies for Retinal Damage due to Age-Related Macular Degeneration: A Review |
| title_full | Choice of Cell Source in Cell-Based Therapies for Retinal Damage due to Age-Related Macular Degeneration: A Review |
| title_fullStr | Choice of Cell Source in Cell-Based Therapies for Retinal Damage due to Age-Related Macular Degeneration: A Review |
| title_full_unstemmed | Choice of Cell Source in Cell-Based Therapies for Retinal Damage due to Age-Related Macular Degeneration: A Review |
| title_short | Choice of Cell Source in Cell-Based Therapies for Retinal Damage due to Age-Related Macular Degeneration: A Review |
| title_sort | choice of cell source in cell based therapies for retinal damage due to age related macular degeneration a review |
| url | http://dx.doi.org/10.1155/2013/465169 |
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