Role of Oxidative Stress in Blood–Brain Barrier Disruption and Neurodegenerative Diseases
Upregulation of reactive oxygen species (ROS) levels is a principal feature observed in the brains of neurodegenerative diseases such as Parkinson’s disease (PD) and Alzheimer’s disease (AD). In these diseases, oxidative stress can disrupt the blood–brain barrier (BBB). This disruption allows neurot...
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| Language: | English |
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MDPI AG
2024-11-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/13/12/1462 |
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| author | Sehwan Kim Un Ju Jung Sang Ryong Kim |
| author_facet | Sehwan Kim Un Ju Jung Sang Ryong Kim |
| author_sort | Sehwan Kim |
| collection | DOAJ |
| description | Upregulation of reactive oxygen species (ROS) levels is a principal feature observed in the brains of neurodegenerative diseases such as Parkinson’s disease (PD) and Alzheimer’s disease (AD). In these diseases, oxidative stress can disrupt the blood–brain barrier (BBB). This disruption allows neurotoxic plasma components, blood cells, and pathogens to enter the brain, leading to increased ROS production, mitochondrial dysfunction, and inflammation. Collectively, these factors result in protein modification, lipid peroxidation, DNA damage, and, ultimately, neural cell damage. In this review article, we present the mechanisms by which oxidative damage leads to BBB breakdown in brain diseases. Additionally, we summarize potential therapeutic approaches aimed at reducing oxidative damage that contributes to BBB disruption in neurodegenerative diseases. |
| format | Article |
| id | doaj-art-0e5cd8e3f87844e6aa34b4177f76acdb |
| institution | OA Journals |
| issn | 2076-3921 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj-art-0e5cd8e3f87844e6aa34b4177f76acdb2025-08-20T02:00:52ZengMDPI AGAntioxidants2076-39212024-11-011312146210.3390/antiox13121462Role of Oxidative Stress in Blood–Brain Barrier Disruption and Neurodegenerative DiseasesSehwan Kim0Un Ju Jung1Sang Ryong Kim2School of Life Science and Biotechnology, Kyungpook National University, Daegu 41566, Republic of KoreaDepartment of Food Science and Nutrition, Pukyong National University, Busan 48513, Republic of KoreaSchool of Life Science and Biotechnology, Kyungpook National University, Daegu 41566, Republic of KoreaUpregulation of reactive oxygen species (ROS) levels is a principal feature observed in the brains of neurodegenerative diseases such as Parkinson’s disease (PD) and Alzheimer’s disease (AD). In these diseases, oxidative stress can disrupt the blood–brain barrier (BBB). This disruption allows neurotoxic plasma components, blood cells, and pathogens to enter the brain, leading to increased ROS production, mitochondrial dysfunction, and inflammation. Collectively, these factors result in protein modification, lipid peroxidation, DNA damage, and, ultimately, neural cell damage. In this review article, we present the mechanisms by which oxidative damage leads to BBB breakdown in brain diseases. Additionally, we summarize potential therapeutic approaches aimed at reducing oxidative damage that contributes to BBB disruption in neurodegenerative diseases.https://www.mdpi.com/2076-3921/13/12/1462neurodegenerative diseasesreactive oxygen speciesoxidative damageblood–brain barrierblood-derived protein |
| spellingShingle | Sehwan Kim Un Ju Jung Sang Ryong Kim Role of Oxidative Stress in Blood–Brain Barrier Disruption and Neurodegenerative Diseases Antioxidants neurodegenerative diseases reactive oxygen species oxidative damage blood–brain barrier blood-derived protein |
| title | Role of Oxidative Stress in Blood–Brain Barrier Disruption and Neurodegenerative Diseases |
| title_full | Role of Oxidative Stress in Blood–Brain Barrier Disruption and Neurodegenerative Diseases |
| title_fullStr | Role of Oxidative Stress in Blood–Brain Barrier Disruption and Neurodegenerative Diseases |
| title_full_unstemmed | Role of Oxidative Stress in Blood–Brain Barrier Disruption and Neurodegenerative Diseases |
| title_short | Role of Oxidative Stress in Blood–Brain Barrier Disruption and Neurodegenerative Diseases |
| title_sort | role of oxidative stress in blood brain barrier disruption and neurodegenerative diseases |
| topic | neurodegenerative diseases reactive oxygen species oxidative damage blood–brain barrier blood-derived protein |
| url | https://www.mdpi.com/2076-3921/13/12/1462 |
| work_keys_str_mv | AT sehwankim roleofoxidativestressinbloodbrainbarrierdisruptionandneurodegenerativediseases AT unjujung roleofoxidativestressinbloodbrainbarrierdisruptionandneurodegenerativediseases AT sangryongkim roleofoxidativestressinbloodbrainbarrierdisruptionandneurodegenerativediseases |