Clinical analysis of low-dos erituximab in the treatment of refractory idiopathic membranous nephropathy
Objective To explore the efficacy and safety of low-dose rituximab（RTX）for refractory idiopathic membranous nephropathy（IMN）.Methods From January 2017 to December 2018,32 cases of refractory IMN with positive anti-PLA2 R antibody were collected.They received low-dose RTX treatment and were followed...
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| Language: | zho |
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Editorial Department of Journal of Clinical Nephrology
2021-01-01
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| Series: | Linchuang shenzangbing zazhi |
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| Online Access: | http://www.lcszb.com/thesisDetails?columnId=57905525&Fpath=home&index=0 |
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| author | Yuan Zhong-fei Liu Xian-yan He Jian |
| author_facet | Yuan Zhong-fei Liu Xian-yan He Jian |
| author_sort | Yuan Zhong-fei |
| collection | DOAJ |
| description | Objective To explore the efficacy and safety of low-dose rituximab（RTX）for refractory idiopathic membranous nephropathy（IMN）.Methods From January 2017 to December 2018,32 cases of refractory IMN with positive anti-PLA2 R antibody were collected.They received low-dose RTX treatment and were followed up for 1 year.Results The overall effective rate of low-dose RTX treatment for refractory IMN was 87.50% with a complete remission rate of 62.50% and a partial remission rate of 25.00%.After low-dose RTX treatment, CD19+B cell count, serum levels of total IgG and anti-PLA2 R antibody declined markedly（P<0.05）and disease severity was closely correlated with anti-PLA2 R antibody level.Adverse reactions of low-dose RTX treatment included agranulocytosis（n=2）,hypotension during infusion（n=2）and pulmonary infection（n=1）.Conclusion Low-dose rituximab is both effective and safe for refractory IMN. |
| format | Article |
| id | doaj-art-0e5529a6872d4d0aa213a3bec4415eeb |
| institution | OA Journals |
| issn | 1671-2390 |
| language | zho |
| publishDate | 2021-01-01 |
| publisher | Editorial Department of Journal of Clinical Nephrology |
| record_format | Article |
| series | Linchuang shenzangbing zazhi |
| spelling | doaj-art-0e5529a6872d4d0aa213a3bec4415eeb2025-08-20T02:28:47ZzhoEditorial Department of Journal of Clinical NephrologyLinchuang shenzangbing zazhi1671-23902021-01-0121521957905525Clinical analysis of low-dos erituximab in the treatment of refractory idiopathic membranous nephropathyYuan Zhong-feiLiu Xian-yanHe JianObjective To explore the efficacy and safety of low-dose rituximab（RTX）for refractory idiopathic membranous nephropathy（IMN）.Methods From January 2017 to December 2018,32 cases of refractory IMN with positive anti-PLA2 R antibody were collected.They received low-dose RTX treatment and were followed up for 1 year.Results The overall effective rate of low-dose RTX treatment for refractory IMN was 87.50% with a complete remission rate of 62.50% and a partial remission rate of 25.00%.After low-dose RTX treatment, CD19+B cell count, serum levels of total IgG and anti-PLA2 R antibody declined markedly（P<0.05）and disease severity was closely correlated with anti-PLA2 R antibody level.Adverse reactions of low-dose RTX treatment included agranulocytosis（n=2）,hypotension during infusion（n=2）and pulmonary infection（n=1）.Conclusion Low-dose rituximab is both effective and safe for refractory IMN.http://www.lcszb.com/thesisDetails?columnId=57905525&Fpath=home&index=0RituximabIdiopathic membranous nephropathyEfficacySafety |
| spellingShingle | Yuan Zhong-fei Liu Xian-yan He Jian Clinical analysis of low-dos erituximab in the treatment of refractory idiopathic membranous nephropathy Linchuang shenzangbing zazhi Rituximab Idiopathic membranous nephropathy Efficacy Safety |
| title | Clinical analysis of low-dos erituximab in the treatment of refractory idiopathic membranous nephropathy |
| title_full | Clinical analysis of low-dos erituximab in the treatment of refractory idiopathic membranous nephropathy |
| title_fullStr | Clinical analysis of low-dos erituximab in the treatment of refractory idiopathic membranous nephropathy |
| title_full_unstemmed | Clinical analysis of low-dos erituximab in the treatment of refractory idiopathic membranous nephropathy |
| title_short | Clinical analysis of low-dos erituximab in the treatment of refractory idiopathic membranous nephropathy |
| title_sort | clinical analysis of low dos erituximab in the treatment of refractory idiopathic membranous nephropathy |
| topic | Rituximab Idiopathic membranous nephropathy Efficacy Safety |
| url | http://www.lcszb.com/thesisDetails?columnId=57905525&Fpath=home&index=0 |
| work_keys_str_mv | AT yuanzhongfei clinicalanalysisoflowdoserituximabinthetreatmentofrefractoryidiopathicmembranousnephropathy AT liuxianyan clinicalanalysisoflowdoserituximabinthetreatmentofrefractoryidiopathicmembranousnephropathy AT hejian clinicalanalysisoflowdoserituximabinthetreatmentofrefractoryidiopathicmembranousnephropathy |