Do Anabolic Androgenic Steroids Really Cause Harm? A Comprehensive Examination of Adverse Effects
Anabolic steroids, synthetic derivatives of testosterone, are frequently employed in clinical settings to address hormonal deficiencies and, controversially, in athletic contexts to augment physical performance. These compounds exert their physiological effects by activating androgen receptors, the...
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| Format: | Article |
| Language: | English |
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Nicolaus Copernicus University in Toruń
2025-02-01
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| Series: | Quality in Sport |
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| Online Access: | https://apcz.umk.pl/QS/article/view/57735 |
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| author | Paweł Siudziński Mateusz Łyko Alicja Skoczylas Jakub Kurasz Wojciech Maj Wiktoria Tomaszewska Wiktoria Podlasiewicz Katarzyna Pala Piotr Dudziak Anna Nowak Maria Golińska |
| author_facet | Paweł Siudziński Mateusz Łyko Alicja Skoczylas Jakub Kurasz Wojciech Maj Wiktoria Tomaszewska Wiktoria Podlasiewicz Katarzyna Pala Piotr Dudziak Anna Nowak Maria Golińska |
| author_sort | Paweł Siudziński |
| collection | DOAJ |
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Anabolic steroids, synthetic derivatives of testosterone, are frequently employed in clinical settings to address hormonal deficiencies and, controversially, in athletic contexts to augment physical performance. These compounds exert their physiological effects by activating androgen receptors, thereby stimulating protein synthesis, promoting muscle hypertrophy, and accelerating tissue regeneration. These processes are mediated through the modulation of insulin-like growth factor-1 (IGF-1) and the inhibition of glucocorticoid-induced catabolism. However, the unsupervised and excessive use of anabolic steroids, often motivated by the pursuit of rapid aesthetic or performance enhancement, is associated with a myriad of adverse health outcomes. Such complications encompass damage to the reproductive system, renal dysfunction, hepatotoxicity, cardiovascular pathology, and neuropsychiatric disturbances. Given their substantial potential for misuse, anabolic steroids are stringently regulated, necessitating that healthcare professionals remain astutely aware of their adverse effects to ensure timely recognition and intervention.
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| format | Article |
| id | doaj-art-0e52900ffae24cc5a5f21ac109cdf513 |
| institution | Kabale University |
| issn | 2450-3118 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nicolaus Copernicus University in Toruń |
| record_format | Article |
| series | Quality in Sport |
| spelling | doaj-art-0e52900ffae24cc5a5f21ac109cdf5132025-02-03T08:23:58ZengNicolaus Copernicus University in ToruńQuality in Sport2450-31182025-02-013710.12775/QS.2025.37.57735Do Anabolic Androgenic Steroids Really Cause Harm? A Comprehensive Examination of Adverse EffectsPaweł Siudziński0https://orcid.org/0009-0002-4476-9412Mateusz Łyko1https://orcid.org/0009-0009-2530-2789Alicja Skoczylas2https://orcid.org/0009-0002-2185-5406Jakub Kurasz3https://orcid.org/0009-0004-3955-1552Wojciech Maj4https://orcid.org/0009-0003-2869-3718Wiktoria Tomaszewska5https://orcid.org/0009-0005-6166-1659Wiktoria Podlasiewicz6https://orcid.org/0009-0001-6578-5297Katarzyna Palahttps://orcid.org/0009-0004-0787-3872Piotr Dudziakhttps://orcid.org/0009-0000-6173-740XAnna Nowakhttps://orcid.org/0009-0005-8833-1107Maria Golińskahttps://orcid.org/0009-0008-2772-6131University of OpoleUniversity of OpoleUniversity of Opole plac Kopernika 11A, 45-040 OpoleUniwersytet OpolskiUniversity of OpoleUniwersytet OpolskiWroclaw Medical University wybrzeże Ludwika Pasteura 1, 50-367 Wrocław Anabolic steroids, synthetic derivatives of testosterone, are frequently employed in clinical settings to address hormonal deficiencies and, controversially, in athletic contexts to augment physical performance. These compounds exert their physiological effects by activating androgen receptors, thereby stimulating protein synthesis, promoting muscle hypertrophy, and accelerating tissue regeneration. These processes are mediated through the modulation of insulin-like growth factor-1 (IGF-1) and the inhibition of glucocorticoid-induced catabolism. However, the unsupervised and excessive use of anabolic steroids, often motivated by the pursuit of rapid aesthetic or performance enhancement, is associated with a myriad of adverse health outcomes. Such complications encompass damage to the reproductive system, renal dysfunction, hepatotoxicity, cardiovascular pathology, and neuropsychiatric disturbances. Given their substantial potential for misuse, anabolic steroids are stringently regulated, necessitating that healthcare professionals remain astutely aware of their adverse effects to ensure timely recognition and intervention. https://apcz.umk.pl/QS/article/view/57735anabolic steroidsadverse effectscardiovascular pathologyhepatotoxityrenal dysfunctionreproductive system |
| spellingShingle | Paweł Siudziński Mateusz Łyko Alicja Skoczylas Jakub Kurasz Wojciech Maj Wiktoria Tomaszewska Wiktoria Podlasiewicz Katarzyna Pala Piotr Dudziak Anna Nowak Maria Golińska Do Anabolic Androgenic Steroids Really Cause Harm? A Comprehensive Examination of Adverse Effects Quality in Sport anabolic steroids adverse effects cardiovascular pathology hepatotoxity renal dysfunction reproductive system |
| title | Do Anabolic Androgenic Steroids Really Cause Harm? A Comprehensive Examination of Adverse Effects |
| title_full | Do Anabolic Androgenic Steroids Really Cause Harm? A Comprehensive Examination of Adverse Effects |
| title_fullStr | Do Anabolic Androgenic Steroids Really Cause Harm? A Comprehensive Examination of Adverse Effects |
| title_full_unstemmed | Do Anabolic Androgenic Steroids Really Cause Harm? A Comprehensive Examination of Adverse Effects |
| title_short | Do Anabolic Androgenic Steroids Really Cause Harm? A Comprehensive Examination of Adverse Effects |
| title_sort | do anabolic androgenic steroids really cause harm a comprehensive examination of adverse effects |
| topic | anabolic steroids adverse effects cardiovascular pathology hepatotoxity renal dysfunction reproductive system |
| url | https://apcz.umk.pl/QS/article/view/57735 |
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