Spontaneous Tumor Lysis Syndrome due to Uterine Leiomyosarcoma with Lung Metastases
Tumor lysis syndrome (TLS) is an oncologic emergency characterized by a combination of metabolic derangements (hyperuricemia, hyperkalemia, hyperphosphatemia, and hypocalcemia) caused by rapid turnover from cell destruction in certain cancers. These metabolic derangements can lead to seizures, cardi...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Case Reports in Critical Care |
| Online Access: | http://dx.doi.org/10.1155/2017/4141287 |
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| _version_ | 1832564169551904768 |
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| author | Vivek Alaigh Debapriya Datta |
| author_facet | Vivek Alaigh Debapriya Datta |
| author_sort | Vivek Alaigh |
| collection | DOAJ |
| description | Tumor lysis syndrome (TLS) is an oncologic emergency characterized by a combination of metabolic derangements (hyperuricemia, hyperkalemia, hyperphosphatemia, and hypocalcemia) caused by rapid turnover from cell destruction in certain cancers. These metabolic derangements can lead to seizures, cardiac arrhythmias, renal failure, and death. TLS is usually seen after the initiation of chemotherapy for hematologic malignancies. TLS occurring spontaneously, without initiation of chemotherapy, is rare and its occurrence in solid tumors is rarer still. We report a case of spontaneous TLS in a patient with leiomyosarcoma of the uterus, with metastasis to lung. Such a case has never been reported before. |
| format | Article |
| id | doaj-art-0e4f71a4c04a43da8c86b816666ed2a8 |
| institution | Kabale University |
| issn | 2090-6420 2090-6439 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Critical Care |
| spelling | doaj-art-0e4f71a4c04a43da8c86b816666ed2a82025-02-03T01:11:33ZengWileyCase Reports in Critical Care2090-64202090-64392017-01-01201710.1155/2017/41412874141287Spontaneous Tumor Lysis Syndrome due to Uterine Leiomyosarcoma with Lung MetastasesVivek Alaigh0Debapriya Datta1Department of Medicine, University of CT Health Center, 263 Farmington Avenue, Farmington, CT 06030, USADivision of Pulmonary-Critical Care Medicine, University of CT Health Center, Farmington, CT 06030, USATumor lysis syndrome (TLS) is an oncologic emergency characterized by a combination of metabolic derangements (hyperuricemia, hyperkalemia, hyperphosphatemia, and hypocalcemia) caused by rapid turnover from cell destruction in certain cancers. These metabolic derangements can lead to seizures, cardiac arrhythmias, renal failure, and death. TLS is usually seen after the initiation of chemotherapy for hematologic malignancies. TLS occurring spontaneously, without initiation of chemotherapy, is rare and its occurrence in solid tumors is rarer still. We report a case of spontaneous TLS in a patient with leiomyosarcoma of the uterus, with metastasis to lung. Such a case has never been reported before.http://dx.doi.org/10.1155/2017/4141287 |
| spellingShingle | Vivek Alaigh Debapriya Datta Spontaneous Tumor Lysis Syndrome due to Uterine Leiomyosarcoma with Lung Metastases Case Reports in Critical Care |
| title | Spontaneous Tumor Lysis Syndrome due to Uterine Leiomyosarcoma with Lung Metastases |
| title_full | Spontaneous Tumor Lysis Syndrome due to Uterine Leiomyosarcoma with Lung Metastases |
| title_fullStr | Spontaneous Tumor Lysis Syndrome due to Uterine Leiomyosarcoma with Lung Metastases |
| title_full_unstemmed | Spontaneous Tumor Lysis Syndrome due to Uterine Leiomyosarcoma with Lung Metastases |
| title_short | Spontaneous Tumor Lysis Syndrome due to Uterine Leiomyosarcoma with Lung Metastases |
| title_sort | spontaneous tumor lysis syndrome due to uterine leiomyosarcoma with lung metastases |
| url | http://dx.doi.org/10.1155/2017/4141287 |
| work_keys_str_mv | AT vivekalaigh spontaneoustumorlysissyndromeduetouterineleiomyosarcomawithlungmetastases AT debapriyadatta spontaneoustumorlysissyndromeduetouterineleiomyosarcomawithlungmetastases |