Influence of TNF-alpha on the efficacy of anemia correction in patients with lymphoproliferative disorders
In this article mechanisms of anaemia development in patients with lymphatic tissue malignant diseases are presented. Therapy efficacy of erythropoiesis-stimulating agents (EPO) in patients with lymphoproliferative disorders and anaemia (n = 21) is studied. Study group included patients with a chron...
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| Language: | Russian |
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ABV-press
2022-11-01
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| Series: | Онкогематология |
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| Online Access: | https://oncohematology.abvpress.ru/ongm/article/view/731 |
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| author | N. A. Romanenko S. S. Bessmeltsev O. E. Rozanova N. S. Karpova K. M. Abdulkadyrov |
| author_facet | N. A. Romanenko S. S. Bessmeltsev O. E. Rozanova N. S. Karpova K. M. Abdulkadyrov |
| author_sort | N. A. Romanenko |
| collection | DOAJ |
| description | In this article mechanisms of anaemia development in patients with lymphatic tissue malignant diseases are presented. Therapy efficacy of erythropoiesis-stimulating agents (EPO) in patients with lymphoproliferative disorders and anaemia (n = 21) is studied. Study group included patients with a chronic lymphoid leukemia (n = 5), indolent lymphomas (n = 7) and multiple myeloma (n = 9). Patients were 49–80 years of age (63.6 ± 8.2 years). The positive response to EPO therapy was considered if hemoglobin level increased on 20 g/l or its rising to 120 g/l. With given therapy hemoglobin level was increased from 86.8 ± 18.5 g/l to 111.4 ± 26.5 g/l (p < 0.001). EPO therapy efficacy was 61.9 % for total group of patients. Importance of TNF-alpha detection as the prognosis factor of EPO therapy efficacy was studied. Patients with low level of TNF-alpha (less than 15 pg/ml) achieved the positive response in 92.9 %, with a high level of TNF-alpha (more than 15 pg/ml) – the positive response was not observed. Inversely proportional correlation between initial TNF-alpha level and therapy response has been established (r = -0.487; p < 0.03; n = 21). Thus, detection of TNF-alpha level in patients with lymphoproliferative disorders before EPO therapy allows to predict therapy response with high degree of significance. |
| format | Article |
| id | doaj-art-0e4ef83caabe4f74bd9265350f9824e9 |
| institution | DOAJ |
| issn | 1818-8346 2413-4023 |
| language | Russian |
| publishDate | 2022-11-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Онкогематология |
| spelling | doaj-art-0e4ef83caabe4f74bd9265350f9824e92025-08-20T03:21:28ZrusABV-pressОнкогематология1818-83462413-40232022-11-01032228609Influence of TNF-alpha on the efficacy of anemia correction in patients with lymphoproliferative disordersN. A. Romanenko0S. S. Bessmeltsev1O. E. Rozanova2N. S. Karpova3K. M. Abdulkadyrov4Russian Federal Medico-biological AgencyRussian Federal Medico-biological AgencyRussian Federal Medico-biological AgencyRussian Federal Medico-biological AgencyRussian Federal Medico-biological AgencyIn this article mechanisms of anaemia development in patients with lymphatic tissue malignant diseases are presented. Therapy efficacy of erythropoiesis-stimulating agents (EPO) in patients with lymphoproliferative disorders and anaemia (n = 21) is studied. Study group included patients with a chronic lymphoid leukemia (n = 5), indolent lymphomas (n = 7) and multiple myeloma (n = 9). Patients were 49–80 years of age (63.6 ± 8.2 years). The positive response to EPO therapy was considered if hemoglobin level increased on 20 g/l or its rising to 120 g/l. With given therapy hemoglobin level was increased from 86.8 ± 18.5 g/l to 111.4 ± 26.5 g/l (p < 0.001). EPO therapy efficacy was 61.9 % for total group of patients. Importance of TNF-alpha detection as the prognosis factor of EPO therapy efficacy was studied. Patients with low level of TNF-alpha (less than 15 pg/ml) achieved the positive response in 92.9 %, with a high level of TNF-alpha (more than 15 pg/ml) – the positive response was not observed. Inversely proportional correlation between initial TNF-alpha level and therapy response has been established (r = -0.487; p < 0.03; n = 21). Thus, detection of TNF-alpha level in patients with lymphoproliferative disorders before EPO therapy allows to predict therapy response with high degree of significance.https://oncohematology.abvpress.ru/ongm/article/view/731anemiachronic lymphocytic leukemiamultiple myelomalymphomarecombinant erythropoietinepoietin alphaeralfontnf-alpha |
| spellingShingle | N. A. Romanenko S. S. Bessmeltsev O. E. Rozanova N. S. Karpova K. M. Abdulkadyrov Influence of TNF-alpha on the efficacy of anemia correction in patients with lymphoproliferative disorders Онкогематология anemia chronic lymphocytic leukemia multiple myeloma lymphoma recombinant erythropoietin epoietin alpha eralfon tnf-alpha |
| title | Influence of TNF-alpha on the efficacy of anemia correction in patients with lymphoproliferative disorders |
| title_full | Influence of TNF-alpha on the efficacy of anemia correction in patients with lymphoproliferative disorders |
| title_fullStr | Influence of TNF-alpha on the efficacy of anemia correction in patients with lymphoproliferative disorders |
| title_full_unstemmed | Influence of TNF-alpha on the efficacy of anemia correction in patients with lymphoproliferative disorders |
| title_short | Influence of TNF-alpha on the efficacy of anemia correction in patients with lymphoproliferative disorders |
| title_sort | influence of tnf alpha on the efficacy of anemia correction in patients with lymphoproliferative disorders |
| topic | anemia chronic lymphocytic leukemia multiple myeloma lymphoma recombinant erythropoietin epoietin alpha eralfon tnf-alpha |
| url | https://oncohematology.abvpress.ru/ongm/article/view/731 |
| work_keys_str_mv | AT naromanenko influenceoftnfalphaontheefficacyofanemiacorrectioninpatientswithlymphoproliferativedisorders AT ssbessmeltsev influenceoftnfalphaontheefficacyofanemiacorrectioninpatientswithlymphoproliferativedisorders AT oerozanova influenceoftnfalphaontheefficacyofanemiacorrectioninpatientswithlymphoproliferativedisorders AT nskarpova influenceoftnfalphaontheefficacyofanemiacorrectioninpatientswithlymphoproliferativedisorders AT kmabdulkadyrov influenceoftnfalphaontheefficacyofanemiacorrectioninpatientswithlymphoproliferativedisorders |