Turning attention to tumor–host interface and focus on the peritumoral heterogeneity of glioblastoma
Abstract Approximately 90% of glioblastoma recurrences occur in the peritumoral brain zone (PBZ), while the spatial heterogeneity of the PBZ is not well studied. In this study, two PBZ tissues and one tumor tissue sample are obtained from each patient via preoperative imaging. We assess the microenv...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-12-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-024-55243-5 |
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| author | Fang Wang Jiawei Dong Yuyun Xu Jiaqi Jin Yan Xu Xiuwei Yan Zhihui Liu Hongtao Zhao Jiheng Zhang Nan Wang Xueyan Hu Xin Gao Lei Xu Chengyun Yang Shuai Ma Jianyang Du Ying Hu Hang Ji Shaoshan Hu |
| author_facet | Fang Wang Jiawei Dong Yuyun Xu Jiaqi Jin Yan Xu Xiuwei Yan Zhihui Liu Hongtao Zhao Jiheng Zhang Nan Wang Xueyan Hu Xin Gao Lei Xu Chengyun Yang Shuai Ma Jianyang Du Ying Hu Hang Ji Shaoshan Hu |
| author_sort | Fang Wang |
| collection | DOAJ |
| description | Abstract Approximately 90% of glioblastoma recurrences occur in the peritumoral brain zone (PBZ), while the spatial heterogeneity of the PBZ is not well studied. In this study, two PBZ tissues and one tumor tissue sample are obtained from each patient via preoperative imaging. We assess the microenvironment and the characteristics of infiltrating immune/tumor cells using various techniques. Our data indicate there are one or more regions with higher cerebral blood flow in PBZ, which we collectively name the “higher cerebral blood flow interface” (HBI). The HBI exhibited more neovascularization than the “lower cerebral blood flow interfaces” (LBI). The HBI tend to have increased infiltration of macrophages and T lymphocytes infiltration compared with that in LBI. There are more tumor cells in the HBI than in LBI, with substantial differences in the gene expression profiles of these tumor cells. HBI may be the key area of PBZ-targeting therapy after surgical resection. |
| format | Article |
| id | doaj-art-0e41fb2894874557a947b0fcd9bf33a9 |
| institution | Kabale University |
| issn | 2041-1723 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-0e41fb2894874557a947b0fcd9bf33a92025-01-05T12:35:31ZengNature PortfolioNature Communications2041-17232024-12-0115111610.1038/s41467-024-55243-5Turning attention to tumor–host interface and focus on the peritumoral heterogeneity of glioblastomaFang Wang0Jiawei Dong1Yuyun Xu2Jiaqi Jin3Yan Xu4Xiuwei Yan5Zhihui Liu6Hongtao Zhao7Jiheng Zhang8Nan Wang9Xueyan Hu10Xin Gao11Lei Xu12Chengyun Yang13Shuai Ma14Jianyang Du15Ying Hu16Hang Ji17Shaoshan Hu18Cancer Center, Department of Neurosurgery, Zhejiang Provincial People’s Hospital，Affiliated People’s Hospital, Hangzhou Medical CollegeCancer Center, Department of Neurosurgery, Zhejiang Provincial People’s Hospital，Affiliated People’s Hospital, Hangzhou Medical CollegeDepartment of Radiology, Zhejiang Provincial People’s Hospital, Hangzhou Medical CollegeCancer Center, Department of Neurosurgery, Zhejiang Provincial People’s Hospital，Affiliated People’s Hospital, Hangzhou Medical CollegeCancer Center, Department of Neurosurgery, Zhejiang Provincial People’s Hospital，Affiliated People’s Hospital, Hangzhou Medical CollegeCancer Center, Department of Neurosurgery, Zhejiang Provincial People’s Hospital，Affiliated People’s Hospital, Hangzhou Medical CollegeCancer Center, Department of Neurosurgery, Zhejiang Provincial People’s Hospital，Affiliated People’s Hospital, Hangzhou Medical CollegeCancer Center, Department of Neurosurgery, Zhejiang Provincial People’s Hospital，Affiliated People’s Hospital, Hangzhou Medical CollegeCancer Center, Department of Neurosurgery, Zhejiang Provincial People’s Hospital，Affiliated People’s Hospital, Hangzhou Medical CollegeCancer Center, Department of Neurosurgery, Zhejiang Provincial People’s Hospital，Affiliated People’s Hospital, Hangzhou Medical CollegeCancer Center, Department of Neurosurgery, Zhejiang Provincial People’s Hospital，Affiliated People’s Hospital, Hangzhou Medical CollegeCancer Center, Department of Neurosurgery, Zhejiang Provincial People’s Hospital，Affiliated People’s Hospital, Hangzhou Medical CollegeCancer Center, Department of Neurosurgery, Zhejiang Provincial People’s Hospital，Affiliated People’s Hospital, Hangzhou Medical CollegeCancer Center, Department of Neurosurgery, Zhejiang Provincial People’s Hospital，Affiliated People’s Hospital, Hangzhou Medical CollegeCancer Center, Department of Neurosurgery, Zhejiang Provincial People’s Hospital，Affiliated People’s Hospital, Hangzhou Medical CollegeCancer Center, Department of Neurosurgery, Zhejiang Provincial People’s Hospital，Affiliated People’s Hospital, Hangzhou Medical CollegeCancer Center, Department of Neurosurgery, Zhejiang Provincial People’s Hospital，Affiliated People’s Hospital, Hangzhou Medical CollegeCancer Center, Department of Neurosurgery, Zhejiang Provincial People’s Hospital，Affiliated People’s Hospital, Hangzhou Medical CollegeCancer Center, Department of Neurosurgery, Zhejiang Provincial People’s Hospital，Affiliated People’s Hospital, Hangzhou Medical CollegeAbstract Approximately 90% of glioblastoma recurrences occur in the peritumoral brain zone (PBZ), while the spatial heterogeneity of the PBZ is not well studied. In this study, two PBZ tissues and one tumor tissue sample are obtained from each patient via preoperative imaging. We assess the microenvironment and the characteristics of infiltrating immune/tumor cells using various techniques. Our data indicate there are one or more regions with higher cerebral blood flow in PBZ, which we collectively name the “higher cerebral blood flow interface” (HBI). The HBI exhibited more neovascularization than the “lower cerebral blood flow interfaces” (LBI). The HBI tend to have increased infiltration of macrophages and T lymphocytes infiltration compared with that in LBI. There are more tumor cells in the HBI than in LBI, with substantial differences in the gene expression profiles of these tumor cells. HBI may be the key area of PBZ-targeting therapy after surgical resection.https://doi.org/10.1038/s41467-024-55243-5 |
| spellingShingle | Fang Wang Jiawei Dong Yuyun Xu Jiaqi Jin Yan Xu Xiuwei Yan Zhihui Liu Hongtao Zhao Jiheng Zhang Nan Wang Xueyan Hu Xin Gao Lei Xu Chengyun Yang Shuai Ma Jianyang Du Ying Hu Hang Ji Shaoshan Hu Turning attention to tumor–host interface and focus on the peritumoral heterogeneity of glioblastoma Nature Communications |
| title | Turning attention to tumor–host interface and focus on the peritumoral heterogeneity of glioblastoma |
| title_full | Turning attention to tumor–host interface and focus on the peritumoral heterogeneity of glioblastoma |
| title_fullStr | Turning attention to tumor–host interface and focus on the peritumoral heterogeneity of glioblastoma |
| title_full_unstemmed | Turning attention to tumor–host interface and focus on the peritumoral heterogeneity of glioblastoma |
| title_short | Turning attention to tumor–host interface and focus on the peritumoral heterogeneity of glioblastoma |
| title_sort | turning attention to tumor host interface and focus on the peritumoral heterogeneity of glioblastoma |
| url | https://doi.org/10.1038/s41467-024-55243-5 |
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