Mechanical Activation of cPLA2 Impedes Fatty Acid β‐Oxidation in Vein Grafts

Mechanical Activation of cPLA2 Impedes Fatty Acid β‐Oxidation in Vein Grafts

Abstract High‐magnitude cyclic stretch from arterial blood pressure significantly contributes to the excessive proliferation and migration of vascular smooth muscle cells (VSMCs), leading to neointima formation in vein grafts. However, the molecular mechanisms remain unclear. This study highlights t...

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Bibliographic Details
Main Authors: Linwei Fan, Yuanjun Tang, Jian Liu, Yueqi Liu, Yiwei Xu, Jiayu Liu, Han Liu, Wei Pang, Yuxuan Guo, Weijuan Yao, Tao Zhang, Qin Peng, Jing Zhou
Format: Article
Language:English
Published: Wiley 2025-01-01
Series:Advanced Science
Subjects:
cell proliferation and migration
fatty acid β‐oxidation
mechanical force
mechanosensory
vascular smooth muscle cell
Online Access:https://doi.org/10.1002/advs.202411559
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