A Model of Left Ventricular Dysfunction Complicated by CAWS Arteritis in DBA/2 Mice
It was reported previously that a Candida albicans water-soluble fraction (CAWS), including a mannoprotein and β-glucan complex, has strong potency in inducing fatal necrotizing arteritis in DBA/2 mice. In this study, histopathological changes and cardiac function were investigated in this system. O...
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Wiley
2012-01-01
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| Series: | International Journal of Vascular Medicine |
| Online Access: | http://dx.doi.org/10.1155/2012/570297 |
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| author | Naoto Hirata Ken-ichi Ishibashi Tatsuya Usui Jiro Yoshioka Satoru Hata Yoshiyuki Adachi Noriko Nagi-Miura Shin Ohta Naohito Ohno |
| author_facet | Naoto Hirata Ken-ichi Ishibashi Tatsuya Usui Jiro Yoshioka Satoru Hata Yoshiyuki Adachi Noriko Nagi-Miura Shin Ohta Naohito Ohno |
| author_sort | Naoto Hirata |
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| description | It was reported previously that a Candida albicans water-soluble fraction (CAWS), including a mannoprotein and β-glucan complex, has strong potency in inducing fatal necrotizing arteritis in DBA/2 mice. In this study, histopathological changes and cardiac function were investigated in this system. One mg/day of CAWS was given to DBA/2 mice via peritoneal injection for five days. The CAWS-treated DBA/2 mice were induced aortitis and died at an incidence of 100% within several weeks. Histological findings included stenosis in the left ventricular outflow tract (LVOT) and severe inflammatory changes of the aortic valve with fibrinoid necrosis. Cardiomegaly was observed and heart weight increased 1.62 fold (𝑃<0.01). Echocardiography revealed a severe reduction in contractility and dilatation of the cavity in the left ventricle (LV): LV fractional shortening (LVFS) decreased from 71% to 38% (𝑃<0.01), and the LV end-diastolic diameter (LVDd) increased from 2.21 mm to 3.26 mm (𝑃<0.01). The titer of BNP mRNA increased in the CAWS-treated group. Severe inflammatory changes resulting from CAWS brought about lethal LV dysfunction by aortic valve deformation with LVOT stenosis. This system is proposed as an easy and useful experimental model of heart failure because CAWS arteritis can be induced by CAWS injection alone. |
| format | Article |
| id | doaj-art-0e3ddd275185406cabf49003bfb1eaee |
| institution | OA Journals |
| issn | 2090-2824 2090-2832 |
| language | English |
| publishDate | 2012-01-01 |
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| series | International Journal of Vascular Medicine |
| spelling | doaj-art-0e3ddd275185406cabf49003bfb1eaee2025-08-20T02:02:25ZengWileyInternational Journal of Vascular Medicine2090-28242090-28322012-01-01201210.1155/2012/570297570297A Model of Left Ventricular Dysfunction Complicated by CAWS Arteritis in DBA/2 MiceNaoto Hirata0Ken-ichi Ishibashi1Tatsuya Usui2Jiro Yoshioka3Satoru Hata4Yoshiyuki Adachi5Noriko Nagi-Miura6Shin Ohta7Naohito Ohno8Department of Pharmacy, Nagano Red Cross Hospital, 5-22-1 Wakasato, Nagano, Nagano 380-8582, JapanLaboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, JapanDepartment of Cardiology, Nagano Red Cross Hospital, 5-22-1 Wakasato, Nagano, Nagano 380-8582, JapanDepartment of Cardiology, Nagano Red Cross Hospital, 5-22-1 Wakasato, Nagano, Nagano 380-8582, JapanDepartment of Pathology, Nagano Red Cross Hospital, 5-22-1 Wakasato, Nagano, Nagano 380-8582, JapanLaboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, JapanLaboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, JapanDepartment of Pharmaceutical Health Care and Science, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, JapanLaboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, JapanIt was reported previously that a Candida albicans water-soluble fraction (CAWS), including a mannoprotein and β-glucan complex, has strong potency in inducing fatal necrotizing arteritis in DBA/2 mice. In this study, histopathological changes and cardiac function were investigated in this system. One mg/day of CAWS was given to DBA/2 mice via peritoneal injection for five days. The CAWS-treated DBA/2 mice were induced aortitis and died at an incidence of 100% within several weeks. Histological findings included stenosis in the left ventricular outflow tract (LVOT) and severe inflammatory changes of the aortic valve with fibrinoid necrosis. Cardiomegaly was observed and heart weight increased 1.62 fold (𝑃<0.01). Echocardiography revealed a severe reduction in contractility and dilatation of the cavity in the left ventricle (LV): LV fractional shortening (LVFS) decreased from 71% to 38% (𝑃<0.01), and the LV end-diastolic diameter (LVDd) increased from 2.21 mm to 3.26 mm (𝑃<0.01). The titer of BNP mRNA increased in the CAWS-treated group. Severe inflammatory changes resulting from CAWS brought about lethal LV dysfunction by aortic valve deformation with LVOT stenosis. This system is proposed as an easy and useful experimental model of heart failure because CAWS arteritis can be induced by CAWS injection alone.http://dx.doi.org/10.1155/2012/570297 |
| spellingShingle | Naoto Hirata Ken-ichi Ishibashi Tatsuya Usui Jiro Yoshioka Satoru Hata Yoshiyuki Adachi Noriko Nagi-Miura Shin Ohta Naohito Ohno A Model of Left Ventricular Dysfunction Complicated by CAWS Arteritis in DBA/2 Mice International Journal of Vascular Medicine |
| title | A Model of Left Ventricular Dysfunction Complicated by CAWS Arteritis in DBA/2 Mice |
| title_full | A Model of Left Ventricular Dysfunction Complicated by CAWS Arteritis in DBA/2 Mice |
| title_fullStr | A Model of Left Ventricular Dysfunction Complicated by CAWS Arteritis in DBA/2 Mice |
| title_full_unstemmed | A Model of Left Ventricular Dysfunction Complicated by CAWS Arteritis in DBA/2 Mice |
| title_short | A Model of Left Ventricular Dysfunction Complicated by CAWS Arteritis in DBA/2 Mice |
| title_sort | model of left ventricular dysfunction complicated by caws arteritis in dba 2 mice |
| url | http://dx.doi.org/10.1155/2012/570297 |
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