Household transmission of the SARS-CoV-2 omicron variant in New Zealand, 2022
Background: Studying the transmissibility of the SARS-CoV-2 and its driving factors is valuable due to the ongoing emergence of new variants. We examined the household transmission characteristics of the Omicron-dominant variant. Methods: The study took place in Wellington, New Zealand, from 7-Febru...
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Elsevier
2025-06-01
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| Series: | Vaccine: X |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590136225000324 |
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| author | Nayyereh Aminisani Q. Sue Huang Lauren Jelley Timothy Wood Tineke Jennings Danielle Currin Ruth Seeds Maritza Marull Amanda Kvalsvig Michael G. Baker Nhung Nghiem Paul G. Thomas Richard J. Webby |
| author_facet | Nayyereh Aminisani Q. Sue Huang Lauren Jelley Timothy Wood Tineke Jennings Danielle Currin Ruth Seeds Maritza Marull Amanda Kvalsvig Michael G. Baker Nhung Nghiem Paul G. Thomas Richard J. Webby |
| author_sort | Nayyereh Aminisani |
| collection | DOAJ |
| description | Background: Studying the transmissibility of the SARS-CoV-2 and its driving factors is valuable due to the ongoing emergence of new variants. We examined the household transmission characteristics of the Omicron-dominant variant. Methods: The study took place in Wellington, New Zealand, from 7-February to 2-October 2022. When an individual had a confirmed case of SARS-CoV-2, all household members were instructed to take a swab every 3rd day until two consecutive negative swabs were obtained from the last person with SARS-CoV-2. Participants were monitored daily for acute respiratory symptoms until no further symptoms. Results: We enrolled 75 households with confirmed cases of SARS-CoV-2 (total enrolled individuals = 306). The median serial interval was 4 days, and the secondary attack rate (SAR) was 60.6 % (95 % confidence interval (CI) 54.1–66.7). The SAR was higher for older household contacts and lower for contacts of fully vaccinated index cases. The SAR was highest when both the index case and the contacts were unvaccinated or received only one vaccine dose (88 %). Conclusions: In this household cohort, the SARS-CoV-2 Omicron variant showed a high SAR which was modifiable by vaccination; the vaccination status of the index case and household members significantly reduced this. |
| format | Article |
| id | doaj-art-0e38663282db4e5ca4cf5fa8bb2fc44d |
| institution | Kabale University |
| issn | 2590-1362 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Vaccine: X |
| spelling | doaj-art-0e38663282db4e5ca4cf5fa8bb2fc44d2025-08-20T03:25:06ZengElsevierVaccine: X2590-13622025-06-012410063810.1016/j.jvacx.2025.100638Household transmission of the SARS-CoV-2 omicron variant in New Zealand, 2022Nayyereh Aminisani0Q. Sue Huang1Lauren Jelley2Timothy Wood3Tineke Jennings4Danielle Currin5Ruth Seeds6Maritza Marull7Amanda Kvalsvig8Michael G. Baker9Nhung Nghiem10Paul G. Thomas11Richard J. Webby12Institute of Environmental Science and Research, Wellington, New Zealand; Corresponding author.Institute of Environmental Science and Research, Wellington, New ZealandInstitute of Environmental Science and Research, Wellington, New Zealand; University of Otago, Wellington & Dunedin, New ZealandInstitute of Environmental Science and Research, Wellington, New ZealandRegional Public Health, Te Whatu Ora – Health New Zealand Capital, Coast and Hutt Valley, Wellington, New ZealandInstitute of Environmental Science and Research, Wellington, New ZealandInstitute of Environmental Science and Research, Wellington, New ZealandInstitute of Environmental Science and Research, Wellington, New ZealandUniversity of Otago, Wellington & Dunedin, New ZealandUniversity of Otago, Wellington & Dunedin, New ZealandUniversity of Otago, Wellington & Dunedin, New ZealandWorld Health Organization Collaborating Center for Influenza, St Jude Children's Research Hospital, Memphis, USAWorld Health Organization Collaborating Center for Influenza, St Jude Children's Research Hospital, Memphis, USABackground: Studying the transmissibility of the SARS-CoV-2 and its driving factors is valuable due to the ongoing emergence of new variants. We examined the household transmission characteristics of the Omicron-dominant variant. Methods: The study took place in Wellington, New Zealand, from 7-February to 2-October 2022. When an individual had a confirmed case of SARS-CoV-2, all household members were instructed to take a swab every 3rd day until two consecutive negative swabs were obtained from the last person with SARS-CoV-2. Participants were monitored daily for acute respiratory symptoms until no further symptoms. Results: We enrolled 75 households with confirmed cases of SARS-CoV-2 (total enrolled individuals = 306). The median serial interval was 4 days, and the secondary attack rate (SAR) was 60.6 % (95 % confidence interval (CI) 54.1–66.7). The SAR was higher for older household contacts and lower for contacts of fully vaccinated index cases. The SAR was highest when both the index case and the contacts were unvaccinated or received only one vaccine dose (88 %). Conclusions: In this household cohort, the SARS-CoV-2 Omicron variant showed a high SAR which was modifiable by vaccination; the vaccination status of the index case and household members significantly reduced this.http://www.sciencedirect.com/science/article/pii/S2590136225000324SARS-CoV-2 omicron variantHousehold transmissionSecondary attack rateSerial interval |
| spellingShingle | Nayyereh Aminisani Q. Sue Huang Lauren Jelley Timothy Wood Tineke Jennings Danielle Currin Ruth Seeds Maritza Marull Amanda Kvalsvig Michael G. Baker Nhung Nghiem Paul G. Thomas Richard J. Webby Household transmission of the SARS-CoV-2 omicron variant in New Zealand, 2022 Vaccine: X SARS-CoV-2 omicron variant Household transmission Secondary attack rate Serial interval |
| title | Household transmission of the SARS-CoV-2 omicron variant in New Zealand, 2022 |
| title_full | Household transmission of the SARS-CoV-2 omicron variant in New Zealand, 2022 |
| title_fullStr | Household transmission of the SARS-CoV-2 omicron variant in New Zealand, 2022 |
| title_full_unstemmed | Household transmission of the SARS-CoV-2 omicron variant in New Zealand, 2022 |
| title_short | Household transmission of the SARS-CoV-2 omicron variant in New Zealand, 2022 |
| title_sort | household transmission of the sars cov 2 omicron variant in new zealand 2022 |
| topic | SARS-CoV-2 omicron variant Household transmission Secondary attack rate Serial interval |
| url | http://www.sciencedirect.com/science/article/pii/S2590136225000324 |
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