Cross-species spill-over potential of the H9N2 bat influenza A virus
Abstract In 2017, a novel influenza A virus (IAV) was isolated from an Egyptian fruit bat. In contrast to other bat influenza viruses, the virus was related to avian A(H9N2) viruses and was probably the result of a bird-to-bat transmission event. To determine the cross-species spill-over potential,...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-024-47635-4 |
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| author | Rabeh El-Shesheny John Franks Ahmed Kandeil Rebecca Badra Jasmine Turner Patrick Seiler Bindumadhav M. Marathe Trushar Jeevan Lisa Kercher Meng Hu Yul Eum Sim Kenrie P. Y. Hui Michael C. W. Chan Andrew J. Thompson Pamela McKenzie Elena A. Govorkova Charles J. Russell Peter Vogel James C. Paulson J. S. Malik Peiris Robert G. Webster Mohamed A. Ali Ghazi Kayali Richard J. Webby |
| author_facet | Rabeh El-Shesheny John Franks Ahmed Kandeil Rebecca Badra Jasmine Turner Patrick Seiler Bindumadhav M. Marathe Trushar Jeevan Lisa Kercher Meng Hu Yul Eum Sim Kenrie P. Y. Hui Michael C. W. Chan Andrew J. Thompson Pamela McKenzie Elena A. Govorkova Charles J. Russell Peter Vogel James C. Paulson J. S. Malik Peiris Robert G. Webster Mohamed A. Ali Ghazi Kayali Richard J. Webby |
| author_sort | Rabeh El-Shesheny |
| collection | DOAJ |
| description | Abstract In 2017, a novel influenza A virus (IAV) was isolated from an Egyptian fruit bat. In contrast to other bat influenza viruses, the virus was related to avian A(H9N2) viruses and was probably the result of a bird-to-bat transmission event. To determine the cross-species spill-over potential, we biologically characterize features of A/bat/Egypt/381OP/2017(H9N2). The virus has a pH inactivation profile and neuraminidase activity similar to those of human-adapted IAVs. Despite the virus having an avian virus–like preference for α2,3 sialic acid receptors, it is unable to replicate in male mallard ducks; however, it readily infects ex-vivo human respiratory cell cultures and replicates in the lungs of female mice. A/bat/Egypt/381OP/2017 replicates in the upper respiratory tract of experimentally-infected male ferrets featuring direct-contact and airborne transmission. These data suggest that the bat A(H9N2) virus has features associated with increased risk to humans without a shift to a preference for α2,6 sialic acid receptors. |
| format | Article |
| id | doaj-art-0e383400a9d3481ebc14bb85730eae93 |
| institution | OA Journals |
| issn | 2041-1723 |
| language | English |
| publishDate | 2024-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-0e383400a9d3481ebc14bb85730eae932025-08-20T02:34:19ZengNature PortfolioNature Communications2041-17232024-04-0115111210.1038/s41467-024-47635-4Cross-species spill-over potential of the H9N2 bat influenza A virusRabeh El-Shesheny0John Franks1Ahmed Kandeil2Rebecca Badra3Jasmine Turner4Patrick Seiler5Bindumadhav M. Marathe6Trushar Jeevan7Lisa Kercher8Meng Hu9Yul Eum Sim10Kenrie P. Y. Hui11Michael C. W. Chan12Andrew J. Thompson13Pamela McKenzie14Elena A. Govorkova15Charles J. Russell16Peter Vogel17James C. Paulson18J. S. Malik Peiris19Robert G. Webster20Mohamed A. Ali21Ghazi Kayali22Richard J. Webby23Center of Scientific Excellence for Influenza Virus, National Research CentreDepartment of Infectious Diseases, St. Jude Children’s Research HospitalCenter of Scientific Excellence for Influenza Virus, National Research CentreHuman LinkDepartment of Infectious Diseases, St. Jude Children’s Research HospitalDepartment of Infectious Diseases, St. Jude Children’s Research HospitalDepartment of Infectious Diseases, St. Jude Children’s Research HospitalDepartment of Infectious Diseases, St. Jude Children’s Research HospitalDepartment of Infectious Diseases, St. Jude Children’s Research HospitalDepartment of Infectious Diseases, St. Jude Children’s Research HospitalDepartment of Biology, Wanek School of Natural Science, High Point UniversitySchool of Public Health, The University of Hong KongSchool of Public Health, The University of Hong KongDepartment of Immunology and Microbiology, The Scripps Research InstituteDepartment of Infectious Diseases, St. Jude Children’s Research HospitalDepartment of Infectious Diseases, St. Jude Children’s Research HospitalDepartment of Infectious Diseases, St. Jude Children’s Research HospitalDepartment of Infectious Diseases, St. Jude Children’s Research HospitalDepartment of Immunology and Microbiology, The Scripps Research InstituteSchool of Public Health, The University of Hong KongDepartment of Infectious Diseases, St. Jude Children’s Research HospitalCenter of Scientific Excellence for Influenza Virus, National Research CentreHuman LinkDepartment of Infectious Diseases, St. Jude Children’s Research HospitalAbstract In 2017, a novel influenza A virus (IAV) was isolated from an Egyptian fruit bat. In contrast to other bat influenza viruses, the virus was related to avian A(H9N2) viruses and was probably the result of a bird-to-bat transmission event. To determine the cross-species spill-over potential, we biologically characterize features of A/bat/Egypt/381OP/2017(H9N2). The virus has a pH inactivation profile and neuraminidase activity similar to those of human-adapted IAVs. Despite the virus having an avian virus–like preference for α2,3 sialic acid receptors, it is unable to replicate in male mallard ducks; however, it readily infects ex-vivo human respiratory cell cultures and replicates in the lungs of female mice. A/bat/Egypt/381OP/2017 replicates in the upper respiratory tract of experimentally-infected male ferrets featuring direct-contact and airborne transmission. These data suggest that the bat A(H9N2) virus has features associated with increased risk to humans without a shift to a preference for α2,6 sialic acid receptors.https://doi.org/10.1038/s41467-024-47635-4 |
| spellingShingle | Rabeh El-Shesheny John Franks Ahmed Kandeil Rebecca Badra Jasmine Turner Patrick Seiler Bindumadhav M. Marathe Trushar Jeevan Lisa Kercher Meng Hu Yul Eum Sim Kenrie P. Y. Hui Michael C. W. Chan Andrew J. Thompson Pamela McKenzie Elena A. Govorkova Charles J. Russell Peter Vogel James C. Paulson J. S. Malik Peiris Robert G. Webster Mohamed A. Ali Ghazi Kayali Richard J. Webby Cross-species spill-over potential of the H9N2 bat influenza A virus Nature Communications |
| title | Cross-species spill-over potential of the H9N2 bat influenza A virus |
| title_full | Cross-species spill-over potential of the H9N2 bat influenza A virus |
| title_fullStr | Cross-species spill-over potential of the H9N2 bat influenza A virus |
| title_full_unstemmed | Cross-species spill-over potential of the H9N2 bat influenza A virus |
| title_short | Cross-species spill-over potential of the H9N2 bat influenza A virus |
| title_sort | cross species spill over potential of the h9n2 bat influenza a virus |
| url | https://doi.org/10.1038/s41467-024-47635-4 |
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