Endocan serum concentration in uninfected newborn infants
Introduction: Endocan is a specific endothelial mediator involved in the inflammatory response. Its role in the diagnosis of sepsis has been studied in adult patients and late onset neonatal sepsis. The clinical signs of early onset sepsis (EOS) are nonspecific and routinely used biomarkers, such a...
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The Journal of Infection in Developing Countries
2019-09-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/11660 |
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| author | Gabriela I Zonda Radu Zonda Andrei T Cernomaz Luminita Paduraru Bogdan D Grigoriu |
| author_facet | Gabriela I Zonda Radu Zonda Andrei T Cernomaz Luminita Paduraru Bogdan D Grigoriu |
| author_sort | Gabriela I Zonda |
| collection | DOAJ |
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Introduction: Endocan is a specific endothelial mediator involved in the inflammatory response. Its role in the diagnosis of sepsis has been studied in adult patients and late onset neonatal sepsis. The clinical signs of early onset sepsis (EOS) are nonspecific and routinely used biomarkers, such as C-reactive protein and procalcitonin, have low sensitivity, specificity and positive predictive value. Endocan could be useful as a biomarker for diagnosis of EOS, but at present normal range values for this molecule have not been reported. The aim of this study is to establish the normal values range for serum endocan in term and preterm newborns without risk factors for EOS and to characterize the variation pattern of its levels at different postnatal moments.
Methodology: Mean endocan serum concentration (ESC) was measured in term and preterm newborns without clinical suspicion of EOS at different moments from birth.
Results: ESC (ng/mL) in term newborns was 1.74+/-0.13 on day 1 and 2.02+/-0.41 on day 3 respectively, (p=0.09). In preterm newborns ESC (ng/mL) was 2.02+/-0.11 and 1.97+/-0.18, (p=0.8) for day 1 and 3 respectively. ESC was not significantly influenced by sex, mode of delivery, evidence of fetal distress or presence of minor birth trauma.
Conclusions: ESC (ng/mL) between the first and third day of life in either term or preterm infants don’t appear to be significantly influenced by factors that are associated with elevation of inflammatory markers, thus using this biomarker for the diagnosis of EOS might reduce the false positive results.
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| format | Article |
| id | doaj-art-0e3738f89b954d09a611012a9bcdb11a |
| institution | OA Journals |
| issn | 1972-2680 |
| language | English |
| publishDate | 2019-09-01 |
| publisher | The Journal of Infection in Developing Countries |
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| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-0e3738f89b954d09a611012a9bcdb11a2025-08-20T02:14:20ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802019-09-01130910.3855/jidc.11660Endocan serum concentration in uninfected newborn infantsGabriela I Zonda0Radu Zonda1Andrei T Cernomaz2Luminita Paduraru3Bogdan D Grigoriu4Division of Neonatology, Department of Mother and Child Care, “Grigore T. Popa” University of Medicine and Pharmacy, Iași, Romania"PetruPoni" Institute of Macromolecular Chemistry, Iași, RomaniaDivision of Pneumology, Department of Medical Specialties III, “Grigore T. Popa” University of Medicine and Pharmacy, Iași, RomaniaDivision of Neonatology, Department of Mother and Child Care, “Grigore T. Popa” University of Medicine and Pharmacy, Iași, RomaniaDivision of Pneumology, Department of Medical Specialties III, “Grigore T. Popa” University of Medicine and Pharmacy, Iași, Romania Introduction: Endocan is a specific endothelial mediator involved in the inflammatory response. Its role in the diagnosis of sepsis has been studied in adult patients and late onset neonatal sepsis. The clinical signs of early onset sepsis (EOS) are nonspecific and routinely used biomarkers, such as C-reactive protein and procalcitonin, have low sensitivity, specificity and positive predictive value. Endocan could be useful as a biomarker for diagnosis of EOS, but at present normal range values for this molecule have not been reported. The aim of this study is to establish the normal values range for serum endocan in term and preterm newborns without risk factors for EOS and to characterize the variation pattern of its levels at different postnatal moments. Methodology: Mean endocan serum concentration (ESC) was measured in term and preterm newborns without clinical suspicion of EOS at different moments from birth. Results: ESC (ng/mL) in term newborns was 1.74+/-0.13 on day 1 and 2.02+/-0.41 on day 3 respectively, (p=0.09). In preterm newborns ESC (ng/mL) was 2.02+/-0.11 and 1.97+/-0.18, (p=0.8) for day 1 and 3 respectively. ESC was not significantly influenced by sex, mode of delivery, evidence of fetal distress or presence of minor birth trauma. Conclusions: ESC (ng/mL) between the first and third day of life in either term or preterm infants don’t appear to be significantly influenced by factors that are associated with elevation of inflammatory markers, thus using this biomarker for the diagnosis of EOS might reduce the false positive results. https://jidc.org/index.php/journal/article/view/11660newbornearly onset sepsisendocanbiomarkerendothelium |
| spellingShingle | Gabriela I Zonda Radu Zonda Andrei T Cernomaz Luminita Paduraru Bogdan D Grigoriu Endocan serum concentration in uninfected newborn infants Journal of Infection in Developing Countries newborn early onset sepsis endocan biomarker endothelium |
| title | Endocan serum concentration in uninfected newborn infants |
| title_full | Endocan serum concentration in uninfected newborn infants |
| title_fullStr | Endocan serum concentration in uninfected newborn infants |
| title_full_unstemmed | Endocan serum concentration in uninfected newborn infants |
| title_short | Endocan serum concentration in uninfected newborn infants |
| title_sort | endocan serum concentration in uninfected newborn infants |
| topic | newborn early onset sepsis endocan biomarker endothelium |
| url | https://jidc.org/index.php/journal/article/view/11660 |
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