Human Nasal Turbinate-Derived Stem Cells for Tissue Engineering and Regenerative Medicine
Mesenchymal stem cells (MSCs) are multipotent progenitor cells present in adult tissues that are recognized as promising candidates for cell therapy due to their ease of access, straightforward isolation, and capacity for bio-preservation with minimal loss of potency. However, the clinical applicati...
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| Language: | English |
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Korean Rhinologic Society
2024-11-01
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| Series: | Journal of Rhinology |
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| Online Access: | http://j-rhinology.org/upload/pdf/jr-2024-00030.pdf |
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| author | Do Hyun Kim Se Hwan Hwang |
| author_facet | Do Hyun Kim Se Hwan Hwang |
| author_sort | Do Hyun Kim |
| collection | DOAJ |
| description | Mesenchymal stem cells (MSCs) are multipotent progenitor cells present in adult tissues that are recognized as promising candidates for cell therapy due to their ease of access, straightforward isolation, and capacity for bio-preservation with minimal loss of potency. However, the clinical application of MSCs faces significant challenges, such as donor site morbidity, underscoring the need for alternative sources. Recent studies have suggested that inferior turbinate tissues, which are commonly removed during turbinate surgery, may be a viable donor site for MSCs. Turbinate surgery is a safe and effective procedure frequently performed to alleviate nasal obstruction, a prevalent chronic condition treated by otolaryngologists. This implies that harvesting MSCs from turbinate tissue for tissue engineering and regenerative medicine could serve as a simple, minimally invasive method with faster healing and minimal risk of morbidity or scarring at the donor site. This review highlights previous research indicating that MSCs derived from human turbinate tissues maintain their stability and demonstrate multi-differentiation potential. Therefore, the turbinate could be an alternative to traditional MSC sources for producing functionally competent cells for future clinical applications. |
| format | Article |
| id | doaj-art-0e33a9b9c77a4e258ac60f53018f5e2e |
| institution | OA Journals |
| issn | 1229-1498 2384-4361 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Korean Rhinologic Society |
| record_format | Article |
| series | Journal of Rhinology |
| spelling | doaj-art-0e33a9b9c77a4e258ac60f53018f5e2e2025-08-20T01:59:17ZengKorean Rhinologic SocietyJournal of Rhinology1229-14982384-43612024-11-0131313313710.18787/jr.2024.00030819Human Nasal Turbinate-Derived Stem Cells for Tissue Engineering and Regenerative MedicineDo Hyun Kim0Se Hwan Hwang1 Department of Otolaryngology-Head and Neck Surgery, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea Department of Otolaryngology-Head and Neck Surgery, Bucheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaMesenchymal stem cells (MSCs) are multipotent progenitor cells present in adult tissues that are recognized as promising candidates for cell therapy due to their ease of access, straightforward isolation, and capacity for bio-preservation with minimal loss of potency. However, the clinical application of MSCs faces significant challenges, such as donor site morbidity, underscoring the need for alternative sources. Recent studies have suggested that inferior turbinate tissues, which are commonly removed during turbinate surgery, may be a viable donor site for MSCs. Turbinate surgery is a safe and effective procedure frequently performed to alleviate nasal obstruction, a prevalent chronic condition treated by otolaryngologists. This implies that harvesting MSCs from turbinate tissue for tissue engineering and regenerative medicine could serve as a simple, minimally invasive method with faster healing and minimal risk of morbidity or scarring at the donor site. This review highlights previous research indicating that MSCs derived from human turbinate tissues maintain their stability and demonstrate multi-differentiation potential. Therefore, the turbinate could be an alternative to traditional MSC sources for producing functionally competent cells for future clinical applications.http://j-rhinology.org/upload/pdf/jr-2024-00030.pdfmesenchymal stem cellsturbinatesnoseengineeringregeneration |
| spellingShingle | Do Hyun Kim Se Hwan Hwang Human Nasal Turbinate-Derived Stem Cells for Tissue Engineering and Regenerative Medicine Journal of Rhinology mesenchymal stem cells turbinates nose engineering regeneration |
| title | Human Nasal Turbinate-Derived Stem Cells for Tissue Engineering and Regenerative Medicine |
| title_full | Human Nasal Turbinate-Derived Stem Cells for Tissue Engineering and Regenerative Medicine |
| title_fullStr | Human Nasal Turbinate-Derived Stem Cells for Tissue Engineering and Regenerative Medicine |
| title_full_unstemmed | Human Nasal Turbinate-Derived Stem Cells for Tissue Engineering and Regenerative Medicine |
| title_short | Human Nasal Turbinate-Derived Stem Cells for Tissue Engineering and Regenerative Medicine |
| title_sort | human nasal turbinate derived stem cells for tissue engineering and regenerative medicine |
| topic | mesenchymal stem cells turbinates nose engineering regeneration |
| url | http://j-rhinology.org/upload/pdf/jr-2024-00030.pdf |
| work_keys_str_mv | AT dohyunkim humannasalturbinatederivedstemcellsfortissueengineeringandregenerativemedicine AT sehwanhwang humannasalturbinatederivedstemcellsfortissueengineeringandregenerativemedicine |