Regulatory mechanisms of fospropofol on cerebral blood flow and metabolism and its clinical applications: Recent advances
Fospropofol is a water-soluble prodrug of propofol that has gained increasing attention in the field of anesthesia due to its gentle modulation of cerebral blood flow and metabolism. This review summarizes the pharmacological mechanisms by which fospropofol regulates cerebral hemodynamics, including...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-07-01
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| Series: | Saudi Journal of Anaesthesia |
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| Online Access: | https://journals.lww.com/10.4103/sja.sja_230_25 |
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| author | Luying Huang Hui Yang |
| author_facet | Luying Huang Hui Yang |
| author_sort | Luying Huang |
| collection | DOAJ |
| description | Fospropofol is a water-soluble prodrug of propofol that has gained increasing attention in the field of anesthesia due to its gentle modulation of cerebral blood flow and metabolism. This review summarizes the pharmacological mechanisms by which fospropofol regulates cerebral hemodynamics, including direct effects on vascular smooth muscle and indirect modulation via suppression of neural metabolic activity. The article also discusses its ability to reduce cerebral metabolic rate, inhibit neuronal excitability, and modulate energy balance, all of which contribute to its potential neuroprotective properties, particularly in ischemia-reperfusion injury. Preclinical and clinical studies suggest that fospropofol exerts antioxidant and anti-inflammatory effects that may further support neural preservation. Clinically, fospropofol has shown value in various scenarios requiring precise neuromanagement, including neurosurgery, anesthesia in elderly patients, intensive care sedation, and perioperative neuroprotection. Despite promising results, further high-quality, large-scale studies are needed to clarify its neuroprotective efficacy across diverse patient populations and surgical contexts. With its favorable pharmacokinetics, controllable depth of sedation, and multitargeted neural effects, fospropofol is poised to become an important tool in individualized neuroanesthesia and brain-protective strategies. |
| format | Article |
| id | doaj-art-0e2f7ff8bf944461b7697d44f63d2ed0 |
| institution | Kabale University |
| issn | 1658-354X 0975-3125 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Saudi Journal of Anaesthesia |
| spelling | doaj-art-0e2f7ff8bf944461b7697d44f63d2ed02025-08-20T03:29:40ZengWolters Kluwer Medknow PublicationsSaudi Journal of Anaesthesia1658-354X0975-31252025-07-0119338739410.4103/sja.sja_230_25Regulatory mechanisms of fospropofol on cerebral blood flow and metabolism and its clinical applications: Recent advancesLuying HuangHui YangFospropofol is a water-soluble prodrug of propofol that has gained increasing attention in the field of anesthesia due to its gentle modulation of cerebral blood flow and metabolism. This review summarizes the pharmacological mechanisms by which fospropofol regulates cerebral hemodynamics, including direct effects on vascular smooth muscle and indirect modulation via suppression of neural metabolic activity. The article also discusses its ability to reduce cerebral metabolic rate, inhibit neuronal excitability, and modulate energy balance, all of which contribute to its potential neuroprotective properties, particularly in ischemia-reperfusion injury. Preclinical and clinical studies suggest that fospropofol exerts antioxidant and anti-inflammatory effects that may further support neural preservation. Clinically, fospropofol has shown value in various scenarios requiring precise neuromanagement, including neurosurgery, anesthesia in elderly patients, intensive care sedation, and perioperative neuroprotection. Despite promising results, further high-quality, large-scale studies are needed to clarify its neuroprotective efficacy across diverse patient populations and surgical contexts. With its favorable pharmacokinetics, controllable depth of sedation, and multitargeted neural effects, fospropofol is poised to become an important tool in individualized neuroanesthesia and brain-protective strategies.https://journals.lww.com/10.4103/sja.sja_230_25anesthesiacerebral blood flowcerebral metabolismfospropofolneuroprotectionindividualized anesthesiaintravenous sedationneurosurgery |
| spellingShingle | Luying Huang Hui Yang Regulatory mechanisms of fospropofol on cerebral blood flow and metabolism and its clinical applications: Recent advances Saudi Journal of Anaesthesia anesthesia cerebral blood flow cerebral metabolism fospropofol neuroprotection individualized anesthesia intravenous sedation neurosurgery |
| title | Regulatory mechanisms of fospropofol on cerebral blood flow and metabolism and its clinical applications: Recent advances |
| title_full | Regulatory mechanisms of fospropofol on cerebral blood flow and metabolism and its clinical applications: Recent advances |
| title_fullStr | Regulatory mechanisms of fospropofol on cerebral blood flow and metabolism and its clinical applications: Recent advances |
| title_full_unstemmed | Regulatory mechanisms of fospropofol on cerebral blood flow and metabolism and its clinical applications: Recent advances |
| title_short | Regulatory mechanisms of fospropofol on cerebral blood flow and metabolism and its clinical applications: Recent advances |
| title_sort | regulatory mechanisms of fospropofol on cerebral blood flow and metabolism and its clinical applications recent advances |
| topic | anesthesia cerebral blood flow cerebral metabolism fospropofol neuroprotection individualized anesthesia intravenous sedation neurosurgery |
| url | https://journals.lww.com/10.4103/sja.sja_230_25 |
| work_keys_str_mv | AT luyinghuang regulatorymechanismsoffospropofoloncerebralbloodflowandmetabolismanditsclinicalapplicationsrecentadvances AT huiyang regulatorymechanismsoffospropofoloncerebralbloodflowandmetabolismanditsclinicalapplicationsrecentadvances |