BDNF improves the survival of mesenchymal stem cells cultured on pre-structured gelatin material containing strontium and calcium phosphates for bone regeneration

BDNF improves the survival of mesenchymal stem cells cultured on pre-structured gelatin material containing strontium and calcium phosphates for bone regeneration

IntroductionThe treatment of osteoporotic fractures is still challenging and may be improved using materials for bone regeneration, such as pre-structured gelatin with calcium and strontium phosphates (PPGC+S), combined with brain-derived neurotrophic factor (BDNF). Recently, it was shown that PPGC+...

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Bibliographic Details
Main Authors: Paul T. Itting, Benjamin Kruppke, Thomas Hanke, Vinu Vijayan, Christian Heiss, Katrin Susanne Lips
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
osteoporosis
apoptosis
bone regeneration material
cytotoxicity
mesenchymal stem cells
brain-derived neurotrophic factor
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2025.1596846/full
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