Advances in personalized gastroenterology and hepatology 2016
Molecular and cell biology have resulted in major advances in our understanding of disease pathogenesis as well as in novel strategies for the diagnosis, therapy and prevention of human diseases. Based on modern molecular, genetic, epigenetic microbiologic and biochemical analyses it is, on the one...
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| Format: | Article |
| Language: | Russian |
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Gastro LLC
2016-08-01
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| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
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| Online Access: | https://www.gastro-j.ru/jour/article/view/54 |
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| _version_ | 1823860102712524800 |
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| author | E. Blum Hubert |
| author_facet | E. Blum Hubert |
| author_sort | E. Blum Hubert |
| collection | DOAJ |
| description | Molecular and cell biology have resulted in major advances in our understanding of disease pathogenesis as well as in novel strategies for the diagnosis, therapy and prevention of human diseases. Based on modern molecular, genetic, epigenetic microbiologic and biochemical analyses it is, on the one hand, possible to identify disease-related point mutations and single nucleotide polymorphisms in the context of genomewide association analyses (GWAS). On the other hand, using high throughput array and other technologies, it is possible to simultaneously analyze thousands of genes (DNA) or gene products (RNA and proteins), resulting in an individual gene or gene expression profile (‘signature’) or to characterize the individual microbiome and its pathogenetic potential. Such data increasingly allow to define the individual disease predisposition or risk and to predict disease prognosis as well as the efficacy of therapeutic strategies in the individual patient (‘personalized medicine’). All these aspects have greatly contributed to the recent advances in the diagnosis, treatment and prevention of human diseases. |
| format | Article |
| id | doaj-art-0e2a669ce7aa404cb6794ae9a42aa825 |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2016-08-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-0e2a669ce7aa404cb6794ae9a42aa8252025-02-10T16:14:34ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732016-08-0126341010.22416/1382-4376-2016-26-3-4-1054Advances in personalized gastroenterology and hepatology 2016E. Blum Hubert0Freiburg University HospitalMolecular and cell biology have resulted in major advances in our understanding of disease pathogenesis as well as in novel strategies for the diagnosis, therapy and prevention of human diseases. Based on modern molecular, genetic, epigenetic microbiologic and biochemical analyses it is, on the one hand, possible to identify disease-related point mutations and single nucleotide polymorphisms in the context of genomewide association analyses (GWAS). On the other hand, using high throughput array and other technologies, it is possible to simultaneously analyze thousands of genes (DNA) or gene products (RNA and proteins), resulting in an individual gene or gene expression profile (‘signature’) or to characterize the individual microbiome and its pathogenetic potential. Such data increasingly allow to define the individual disease predisposition or risk and to predict disease prognosis as well as the efficacy of therapeutic strategies in the individual patient (‘personalized medicine’). All these aspects have greatly contributed to the recent advances in the diagnosis, treatment and prevention of human diseases.https://www.gastro-j.ru/jour/article/view/54структура человеческого геномаполногеномное ассоциативное сканированиепроект по исследованию микробиома человекапрофиль генной экспрессиииндивидуализированная противоопухолевая терапияблокада иммунных контрольных точек |
| spellingShingle | E. Blum Hubert Advances in personalized gastroenterology and hepatology 2016 Российский журнал гастроэнтерологии, гепатологии, колопроктологии структура человеческого генома полногеномное ассоциативное сканирование проект по исследованию микробиома человека профиль генной экспрессии индивидуализированная противоопухолевая терапия блокада иммунных контрольных точек |
| title | Advances in personalized gastroenterology and hepatology 2016 |
| title_full | Advances in personalized gastroenterology and hepatology 2016 |
| title_fullStr | Advances in personalized gastroenterology and hepatology 2016 |
| title_full_unstemmed | Advances in personalized gastroenterology and hepatology 2016 |
| title_short | Advances in personalized gastroenterology and hepatology 2016 |
| title_sort | advances in personalized gastroenterology and hepatology 2016 |
| topic | структура человеческого генома полногеномное ассоциативное сканирование проект по исследованию микробиома человека профиль генной экспрессии индивидуализированная противоопухолевая терапия блокада иммунных контрольных точек |
| url | https://www.gastro-j.ru/jour/article/view/54 |
| work_keys_str_mv | AT eblumhubert advancesinpersonalizedgastroenterologyandhepatology2016 |