Effect of zinc supplementation on diarrhoea in HIV infection: a protocol for systematic review and meta-analysis of controlled clinical trials
Introduction Diarrhoea is a common problem in people living with HIV. Some trials have demonstrated the effectiveness of zinc supplementation in the prevention and treatment of diarrhoea; however, several studies employing the effectiveness of zinc supplementation for reducing diarrhoea in HIV infec...
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BMJ Publishing Group
2025-07-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/15/7/e092287.full |
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| author | Chang Liu Jiyuan Shi Peiling Li Panpan Guo Shitong Guo Shujing Suo |
| author_facet | Chang Liu Jiyuan Shi Peiling Li Panpan Guo Shitong Guo Shujing Suo |
| author_sort | Chang Liu |
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| description | Introduction Diarrhoea is a common problem in people living with HIV. Some trials have demonstrated the effectiveness of zinc supplementation in the prevention and treatment of diarrhoea; however, several studies employing the effectiveness of zinc supplementation for reducing diarrhoea in HIV infection have reported heterogeneous outcomes, necessitating a systematic review to provide an exhaustive summary of current evidence. This review aims to pool the available evidence on the effectiveness of zinc supplementation on diarrhoea in HIV infection.Methods and analysis This systematic review protocol follows the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols. A systematic literature search will be conducted in Chinese and English databases, including PubMed, Scopus, Google Scholar, Cochrane Library, EMBASE, Web of Science, China National Knowledge Infrastructure, Chinese Scientific Journal Database, SinoMed and Wanfang, as part of our search strategy from inception to 17 May 2025. Two reviewers will independently identify eligible studies and extract data. The risk of bias in included studies will be assessed using version 2 of the Cochrane risk-of-bias tool for randomised trials. The risk ratio and 95% CIs will be used to estimate the efficacy of treatment and evaluation approach to rate the certainty of evidence. Cochran’s Q and the I2 will be used to evaluate statistical heterogeneity. Data will be analysed using Stata version 13.0.Ethics and dissemination Because no patients were involved, ethical approval was not required. The final results of this research will be submitted to a peer-reviewed journal or presented at relevant conferences, and any deviations from this protocol will be recorded and explained in the final report.PROSPERO registration number CRD42022328098. |
| format | Article |
| id | doaj-art-0e229344ab3f4fe9b58782d1c14a2bd3 |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMJ Publishing Group |
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| series | BMJ Open |
| spelling | doaj-art-0e229344ab3f4fe9b58782d1c14a2bd32025-08-20T03:31:34ZengBMJ Publishing GroupBMJ Open2044-60552025-07-0115710.1136/bmjopen-2024-092287Effect of zinc supplementation on diarrhoea in HIV infection: a protocol for systematic review and meta-analysis of controlled clinical trialsChang Liu0Jiyuan Shi1Peiling Li2Panpan Guo3Shitong Guo4Shujing Suo5Zhengzhou University, Zhengzhou, Henan, ChinaBeijing University of Chinese Medicine, Beijing, ChinaZhengzhou University, Zhengzhou, Henan, ChinaZhengzhou University, Zhengzhou, Henan, ChinaZhengzhou University, Zhengzhou, Henan, ChinaZhengzhou University, Zhengzhou, Henan, ChinaIntroduction Diarrhoea is a common problem in people living with HIV. Some trials have demonstrated the effectiveness of zinc supplementation in the prevention and treatment of diarrhoea; however, several studies employing the effectiveness of zinc supplementation for reducing diarrhoea in HIV infection have reported heterogeneous outcomes, necessitating a systematic review to provide an exhaustive summary of current evidence. This review aims to pool the available evidence on the effectiveness of zinc supplementation on diarrhoea in HIV infection.Methods and analysis This systematic review protocol follows the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols. A systematic literature search will be conducted in Chinese and English databases, including PubMed, Scopus, Google Scholar, Cochrane Library, EMBASE, Web of Science, China National Knowledge Infrastructure, Chinese Scientific Journal Database, SinoMed and Wanfang, as part of our search strategy from inception to 17 May 2025. Two reviewers will independently identify eligible studies and extract data. The risk of bias in included studies will be assessed using version 2 of the Cochrane risk-of-bias tool for randomised trials. The risk ratio and 95% CIs will be used to estimate the efficacy of treatment and evaluation approach to rate the certainty of evidence. Cochran’s Q and the I2 will be used to evaluate statistical heterogeneity. Data will be analysed using Stata version 13.0.Ethics and dissemination Because no patients were involved, ethical approval was not required. The final results of this research will be submitted to a peer-reviewed journal or presented at relevant conferences, and any deviations from this protocol will be recorded and explained in the final report.PROSPERO registration number CRD42022328098.https://bmjopen.bmj.com/content/15/7/e092287.full |
| spellingShingle | Chang Liu Jiyuan Shi Peiling Li Panpan Guo Shitong Guo Shujing Suo Effect of zinc supplementation on diarrhoea in HIV infection: a protocol for systematic review and meta-analysis of controlled clinical trials BMJ Open |
| title | Effect of zinc supplementation on diarrhoea in HIV infection: a protocol for systematic review and meta-analysis of controlled clinical trials |
| title_full | Effect of zinc supplementation on diarrhoea in HIV infection: a protocol for systematic review and meta-analysis of controlled clinical trials |
| title_fullStr | Effect of zinc supplementation on diarrhoea in HIV infection: a protocol for systematic review and meta-analysis of controlled clinical trials |
| title_full_unstemmed | Effect of zinc supplementation on diarrhoea in HIV infection: a protocol for systematic review and meta-analysis of controlled clinical trials |
| title_short | Effect of zinc supplementation on diarrhoea in HIV infection: a protocol for systematic review and meta-analysis of controlled clinical trials |
| title_sort | effect of zinc supplementation on diarrhoea in hiv infection a protocol for systematic review and meta analysis of controlled clinical trials |
| url | https://bmjopen.bmj.com/content/15/7/e092287.full |
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