Pathogenesis, treatment, and prevention of arterial hypertension in Type 2 diabetes mellitus patients
Aim. To study arteriolar blood flow velocity and salt consumption in patients with Type 2 diabetes mellitus (DM-2) and arterial hypertension (AH); to clarify the causes and pathogenetic mechanisms of the latter.Material and methods. In total, 258 patients with DM-2 and AH were examined (mean age 54+...
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| Format: | Article |
| Language: | Russian |
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«SILICEA-POLIGRAF» LLC
2008-06-01
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| Series: | Кардиоваскулярная терапия и профилактика |
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| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/1345 |
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| author | V. S. Volkov E. V. E.V. Rudenko S. A. Rokkina |
| author_facet | V. S. Volkov E. V. E.V. Rudenko S. A. Rokkina |
| author_sort | V. S. Volkov |
| collection | DOAJ |
| description | Aim. To study arteriolar blood flow velocity and salt consumption in patients with Type 2 diabetes mellitus (DM-2) and arterial hypertension (AH); to clarify the causes and pathogenetic mechanisms of the latter.Material and methods. In total, 258 patients with DM-2 and AH were examined (mean age 54+1,16 years, disease duration 9,8+0,91 years). The control group (CG) included 110 age-matched healthy people. Taste sensitivity to salt (TSS), 24-hour urinary sodium excretion, and microcirculatory Doppler ultrasound were performed.Results. In patients with DM-2 and AH, decreased TSS resulted in involuntary increase of salt intake with food, which was confirmed by increased urinary sodium excretion. Arteriolar blood flow was significantly decreased in DM-2 participants, which indirectly pointed to arteriolar vasodilatation in AH.Conclusion. Volume-dependent mechanism (hypervolemia) plays a leading role in AH genesis among DM-2 patients. This should be taken into consideration while planning treatment and prevention strategies in individuals with DM-2 and AH. |
| format | Article |
| id | doaj-art-0e1cdae180fe4e3cb771c05a5b4c409c |
| institution | DOAJ |
| issn | 1728-8800 2619-0125 |
| language | Russian |
| publishDate | 2008-06-01 |
| publisher | «SILICEA-POLIGRAF» LLC |
| record_format | Article |
| series | Кардиоваскулярная терапия и профилактика |
| spelling | doaj-art-0e1cdae180fe4e3cb771c05a5b4c409c2025-08-20T02:59:56Zrus«SILICEA-POLIGRAF» LLCКардиоваскулярная терапия и профилактика1728-88002619-01252008-06-017314171055Pathogenesis, treatment, and prevention of arterial hypertension in Type 2 diabetes mellitus patientsV. S. Volkov0E. V. E.V. Rudenko1S. A. Rokkina2Tver State Medical Academy. TverTver State Medical Academy. TverTver State Medical Academy. TverAim. To study arteriolar blood flow velocity and salt consumption in patients with Type 2 diabetes mellitus (DM-2) and arterial hypertension (AH); to clarify the causes and pathogenetic mechanisms of the latter.Material and methods. In total, 258 patients with DM-2 and AH were examined (mean age 54+1,16 years, disease duration 9,8+0,91 years). The control group (CG) included 110 age-matched healthy people. Taste sensitivity to salt (TSS), 24-hour urinary sodium excretion, and microcirculatory Doppler ultrasound were performed.Results. In patients with DM-2 and AH, decreased TSS resulted in involuntary increase of salt intake with food, which was confirmed by increased urinary sodium excretion. Arteriolar blood flow was significantly decreased in DM-2 participants, which indirectly pointed to arteriolar vasodilatation in AH.Conclusion. Volume-dependent mechanism (hypervolemia) plays a leading role in AH genesis among DM-2 patients. This should be taken into consideration while planning treatment and prevention strategies in individuals with DM-2 and AH.https://cardiovascular.elpub.ru/jour/article/view/1345type 2 diabetes mellitusarterial hypertensionsaltarteriolar blood flow |
| spellingShingle | V. S. Volkov E. V. E.V. Rudenko S. A. Rokkina Pathogenesis, treatment, and prevention of arterial hypertension in Type 2 diabetes mellitus patients Кардиоваскулярная терапия и профилактика type 2 diabetes mellitus arterial hypertension salt arteriolar blood flow |
| title | Pathogenesis, treatment, and prevention of arterial hypertension in Type 2 diabetes mellitus patients |
| title_full | Pathogenesis, treatment, and prevention of arterial hypertension in Type 2 diabetes mellitus patients |
| title_fullStr | Pathogenesis, treatment, and prevention of arterial hypertension in Type 2 diabetes mellitus patients |
| title_full_unstemmed | Pathogenesis, treatment, and prevention of arterial hypertension in Type 2 diabetes mellitus patients |
| title_short | Pathogenesis, treatment, and prevention of arterial hypertension in Type 2 diabetes mellitus patients |
| title_sort | pathogenesis treatment and prevention of arterial hypertension in type 2 diabetes mellitus patients |
| topic | type 2 diabetes mellitus arterial hypertension salt arteriolar blood flow |
| url | https://cardiovascular.elpub.ru/jour/article/view/1345 |
| work_keys_str_mv | AT vsvolkov pathogenesistreatmentandpreventionofarterialhypertensionintype2diabetesmellituspatients AT evevrudenko pathogenesistreatmentandpreventionofarterialhypertensionintype2diabetesmellituspatients AT sarokkina pathogenesistreatmentandpreventionofarterialhypertensionintype2diabetesmellituspatients |