Long-Term Outcomes of Laparoscopic Anatomical versus Non-Anatomical Liver Resection for Hepatocellular Carcinoma
Songyao Leng,1,2,* Li Cao,1,* Xingru Wang,1,3 Jian Chen,1 Xiaojun Wang,1 Yong Cao,1 Xuesong Li,1 Shuguo Zheng,1 Feng Tian,1 Jianwei Li1 1Department of Hepatobiliary Surgery, Southwest Hospital, Army Medical University, Chongqing, People’s Republic of China; 2Department of General Sur...
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Dove Medical Press
2024-12-01
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| Series: | Journal of Hepatocellular Carcinoma |
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| author | Leng S Cao L Wang X Chen J Wang X Cao Y Li X Zheng S Tian F Li J |
| author_facet | Leng S Cao L Wang X Chen J Wang X Cao Y Li X Zheng S Tian F Li J |
| author_sort | Leng S |
| collection | DOAJ |
| description | Songyao Leng,1,2,* Li Cao,1,* Xingru Wang,1,3 Jian Chen,1 Xiaojun Wang,1 Yong Cao,1 Xuesong Li,1 Shuguo Zheng,1 Feng Tian,1 Jianwei Li1 1Department of Hepatobiliary Surgery, Southwest Hospital, Army Medical University, Chongqing, People’s Republic of China; 2Department of General Surgery, The First People’s Hospital of Neijiang, Neijiang, Sichuan, People’s Republic of China; 3Department of Hepatobiliary Surgery, Qujing Second People’s Hospital of Yunnan Province, Qujing, Yunnan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jianwei Li; Feng Tian, Department of Hepatobiliary Surgery, Southwest Hospital, Army Medical University, No. 30 Gaotanyan Street, Shapingba District, Chongqing, 400038, People’s Republic of China, Email ljianwei1015@yeah.net; tianfeng@tmmu.edu.cnObjective: The objective of this study was to investigate the long-term outcomes between laparoscopic anatomical liver resection (LAR) and laparoscopic non-anatomical liver resection (LNAR) in patients with hepatocellular carcinoma (HCC).Methods: In this single-center retrospective cohort study, 1773 patients, from January 2009 to December 2017, were assessed for inclusion. After exclusions, 661 patients were included: 304 patients received LAR and 357 patients received LNAR. Propensity score matching (PSM) with 1:1 ratio was used to eliminate the selection bias between LAR and LNAR groups. The Kaplan–Meier and Cox models were used for survival analysis.Results: After PSM, 250 patients were in LAR or LNAR group, respectively. The overall survival (OS) had no significant difference between LAR and LNAR by Kaplan–Meier analysis. While, LAR had better disease-free survival (DFS) compared with LNAR (Log-rank P=0.035). The cumulative 5-year DFS rates were 48% for LAR, and 38% for LNAR. By Cox analysis, LAR was an independent risk factor of DFS (HR=1.308, P=0.030). In subgroup analysis for tumor size ≤ 5 cm, 207 patients were in LAR or LNAR subgroup after PSM. LAR had better DFS compared with LNAR (Log-rank P=0.033). LAR was an independent risk factor of DFS (HR=1.333, P=0.036). The cumulative 5-year DFS rates were 50% for LAR, and 39% for LNAR. In another subgroup analysis for tumor size > 5 cm, 43 patients were in LAR or LNAR subgroup after PSM. The DFS had no significant difference between LAR and LNAR (Log-rank P=0.912).Conclusion: LAR is preferred for HCC patients with tumor size ≤ 5cm compared with LNAR because of the better DFS. For patients with tumor size > 5cm, LAR and LNAR might be alternative procedures with comparable long-term outcomes.Keywords: Hepatocellular carcinoma, laparoscopic anatomical liver resection, laparoscopic non-anatomical liver resection, outcome, tumor size |
| format | Article |
| id | doaj-art-0e1b15a658d443dca05fcd72b4566555 |
| institution | OA Journals |
| issn | 2253-5969 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Journal of Hepatocellular Carcinoma |
| spelling | doaj-art-0e1b15a658d443dca05fcd72b45665552025-08-20T02:18:57ZengDove Medical PressJournal of Hepatocellular Carcinoma2253-59692024-12-01Volume 112413242597982Long-Term Outcomes of Laparoscopic Anatomical versus Non-Anatomical Liver Resection for Hepatocellular CarcinomaLeng SCao LWang XChen JWang XCao YLi XZheng STian FLi JSongyao Leng,1,2,* Li Cao,1,* Xingru Wang,1,3 Jian Chen,1 Xiaojun Wang,1 Yong Cao,1 Xuesong Li,1 Shuguo Zheng,1 Feng Tian,1 Jianwei Li1 1Department of Hepatobiliary Surgery, Southwest Hospital, Army Medical University, Chongqing, People’s Republic of China; 2Department of General Surgery, The First People’s Hospital of Neijiang, Neijiang, Sichuan, People’s Republic of China; 3Department of Hepatobiliary Surgery, Qujing Second People’s Hospital of Yunnan Province, Qujing, Yunnan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jianwei Li; Feng Tian, Department of Hepatobiliary Surgery, Southwest Hospital, Army Medical University, No. 30 Gaotanyan Street, Shapingba District, Chongqing, 400038, People’s Republic of China, Email ljianwei1015@yeah.net; tianfeng@tmmu.edu.cnObjective: The objective of this study was to investigate the long-term outcomes between laparoscopic anatomical liver resection (LAR) and laparoscopic non-anatomical liver resection (LNAR) in patients with hepatocellular carcinoma (HCC).Methods: In this single-center retrospective cohort study, 1773 patients, from January 2009 to December 2017, were assessed for inclusion. After exclusions, 661 patients were included: 304 patients received LAR and 357 patients received LNAR. Propensity score matching (PSM) with 1:1 ratio was used to eliminate the selection bias between LAR and LNAR groups. The Kaplan–Meier and Cox models were used for survival analysis.Results: After PSM, 250 patients were in LAR or LNAR group, respectively. The overall survival (OS) had no significant difference between LAR and LNAR by Kaplan–Meier analysis. While, LAR had better disease-free survival (DFS) compared with LNAR (Log-rank P=0.035). The cumulative 5-year DFS rates were 48% for LAR, and 38% for LNAR. By Cox analysis, LAR was an independent risk factor of DFS (HR=1.308, P=0.030). In subgroup analysis for tumor size ≤ 5 cm, 207 patients were in LAR or LNAR subgroup after PSM. LAR had better DFS compared with LNAR (Log-rank P=0.033). LAR was an independent risk factor of DFS (HR=1.333, P=0.036). The cumulative 5-year DFS rates were 50% for LAR, and 39% for LNAR. In another subgroup analysis for tumor size > 5 cm, 43 patients were in LAR or LNAR subgroup after PSM. The DFS had no significant difference between LAR and LNAR (Log-rank P=0.912).Conclusion: LAR is preferred for HCC patients with tumor size ≤ 5cm compared with LNAR because of the better DFS. For patients with tumor size > 5cm, LAR and LNAR might be alternative procedures with comparable long-term outcomes.Keywords: Hepatocellular carcinoma, laparoscopic anatomical liver resection, laparoscopic non-anatomical liver resection, outcome, tumor sizehttps://www.dovepress.com/long-term-outcomes-of-laparoscopic-anatomical-versus-non-anatomical-li-peer-reviewed-fulltext-article-JHChepatocellular carcinomalaparoscopic anatomical liver resectionlaparoscopic non-anatomical liver resectionoutcometumor size. |
| spellingShingle | Leng S Cao L Wang X Chen J Wang X Cao Y Li X Zheng S Tian F Li J Long-Term Outcomes of Laparoscopic Anatomical versus Non-Anatomical Liver Resection for Hepatocellular Carcinoma Journal of Hepatocellular Carcinoma hepatocellular carcinoma laparoscopic anatomical liver resection laparoscopic non-anatomical liver resection outcome tumor size. |
| title | Long-Term Outcomes of Laparoscopic Anatomical versus Non-Anatomical Liver Resection for Hepatocellular Carcinoma |
| title_full | Long-Term Outcomes of Laparoscopic Anatomical versus Non-Anatomical Liver Resection for Hepatocellular Carcinoma |
| title_fullStr | Long-Term Outcomes of Laparoscopic Anatomical versus Non-Anatomical Liver Resection for Hepatocellular Carcinoma |
| title_full_unstemmed | Long-Term Outcomes of Laparoscopic Anatomical versus Non-Anatomical Liver Resection for Hepatocellular Carcinoma |
| title_short | Long-Term Outcomes of Laparoscopic Anatomical versus Non-Anatomical Liver Resection for Hepatocellular Carcinoma |
| title_sort | long term outcomes of laparoscopic anatomical versus non anatomical liver resection for hepatocellular carcinoma |
| topic | hepatocellular carcinoma laparoscopic anatomical liver resection laparoscopic non-anatomical liver resection outcome tumor size. |
| url | https://www.dovepress.com/long-term-outcomes-of-laparoscopic-anatomical-versus-non-anatomical-li-peer-reviewed-fulltext-article-JHC |
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