Elevated plasma phospholipase A2 and platelet-activating factor acetylhydrolase activity in colorectal cancer

This clinical study reports that blood levels of the pro-inflammatory mediator platelet-activating factor (PAF) did not change in colorectal cancer patients. In contrast, plasma levels of two enzymatic activities, one implicated in PAF production (i.e. phospholipase A2) and one in PAF degradation (i...

Full description

Saved in:
Bibliographic Details
Main Authors: Yves Denizot, Véronique Truffinet, Stéphane Bouvier, Alain Gainant, Pierre Cubertafond, Muriel Mathonnet
Format: Article
Language:English
Published: Wiley 2004-01-01
Series:Mediators of Inflammation
Online Access:http://dx.doi.org/10.1080/09629350410001664824
Tags: Add Tag
No Tags, Be the first to tag this record!
_version_ 1832556041574809600
author Yves Denizot
Véronique Truffinet
Stéphane Bouvier
Alain Gainant
Pierre Cubertafond
Muriel Mathonnet
author_facet Yves Denizot
Véronique Truffinet
Stéphane Bouvier
Alain Gainant
Pierre Cubertafond
Muriel Mathonnet
author_sort Yves Denizot
collection DOAJ
description This clinical study reports that blood levels of the pro-inflammatory mediator platelet-activating factor (PAF) did not change in colorectal cancer patients. In contrast, plasma levels of two enzymatic activities, one implicated in PAF production (i.e. phospholipase A2) and one in PAF degradation (i.e. PAF acetylhydrolase activity) were significantly elevated.
format Article
id doaj-art-0e1a4488fc0946239737883e8526c5d9
institution Kabale University
issn 0962-9351
1466-1861
language English
publishDate 2004-01-01
publisher Wiley
record_format Article
series Mediators of Inflammation
spelling doaj-art-0e1a4488fc0946239737883e8526c5d92025-02-03T05:46:28ZengWileyMediators of Inflammation0962-93511466-18612004-01-01131535410.1080/09629350410001664824Elevated plasma phospholipase A2 and platelet-activating factor acetylhydrolase activity in colorectal cancerYves Denizot0Véronique Truffinet1Stéphane Bouvier2Alain Gainant3Pierre Cubertafond4Muriel Mathonnet5UMR CNRS 6101, Laboratoire d’immunologie, Faculté de Médecine, 2 rue Dr. Marcland, Limoges 87025, FranceUMR CNRS 6101, Laboratoire d’immunologie, Faculté de Médecine, 2 rue Dr. Marcland, Limoges 87025, FranceService de Chirurgie Digestive, Endocrinienne et Générale, 2 avenue M. Luther King, Limoges 87025, FranceService de Chirurgie Digestive, Endocrinienne et Générale, 2 avenue M. Luther King, Limoges 87025, FranceService de Chirurgie Digestive, Endocrinienne et Générale, 2 avenue M. Luther King, Limoges 87025, FranceService de Chirurgie Digestive, Endocrinienne et Générale, 2 avenue M. Luther King, Limoges 87025, FranceThis clinical study reports that blood levels of the pro-inflammatory mediator platelet-activating factor (PAF) did not change in colorectal cancer patients. In contrast, plasma levels of two enzymatic activities, one implicated in PAF production (i.e. phospholipase A2) and one in PAF degradation (i.e. PAF acetylhydrolase activity) were significantly elevated.http://dx.doi.org/10.1080/09629350410001664824
spellingShingle Yves Denizot
Véronique Truffinet
Stéphane Bouvier
Alain Gainant
Pierre Cubertafond
Muriel Mathonnet
Elevated plasma phospholipase A2 and platelet-activating factor acetylhydrolase activity in colorectal cancer
Mediators of Inflammation
title Elevated plasma phospholipase A2 and platelet-activating factor acetylhydrolase activity in colorectal cancer
title_full Elevated plasma phospholipase A2 and platelet-activating factor acetylhydrolase activity in colorectal cancer
title_fullStr Elevated plasma phospholipase A2 and platelet-activating factor acetylhydrolase activity in colorectal cancer
title_full_unstemmed Elevated plasma phospholipase A2 and platelet-activating factor acetylhydrolase activity in colorectal cancer
title_short Elevated plasma phospholipase A2 and platelet-activating factor acetylhydrolase activity in colorectal cancer
title_sort elevated plasma phospholipase a2 and platelet activating factor acetylhydrolase activity in colorectal cancer
url http://dx.doi.org/10.1080/09629350410001664824
work_keys_str_mv AT yvesdenizot elevatedplasmaphospholipasea2andplateletactivatingfactoracetylhydrolaseactivityincolorectalcancer
AT veroniquetruffinet elevatedplasmaphospholipasea2andplateletactivatingfactoracetylhydrolaseactivityincolorectalcancer
AT stephanebouvier elevatedplasmaphospholipasea2andplateletactivatingfactoracetylhydrolaseactivityincolorectalcancer
AT alaingainant elevatedplasmaphospholipasea2andplateletactivatingfactoracetylhydrolaseactivityincolorectalcancer
AT pierrecubertafond elevatedplasmaphospholipasea2andplateletactivatingfactoracetylhydrolaseactivityincolorectalcancer
AT murielmathonnet elevatedplasmaphospholipasea2andplateletactivatingfactoracetylhydrolaseactivityincolorectalcancer