Effects of fluvastatin, valsartan, and their combination on endothelial function in patients with arterial hypertension and dyslipidemia
Aim. To study the effects of an angiotensin II receptor antagonist (ARA II) valsartan, a statin (fluvastatin XL), and their combination on endothelial function (EF) in patients with arterial hypertension (AH) and dyslipidemia (DLP).Material and methods. In total, 30 patients with untreated, non-comp...
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«SILICEA-POLIGRAF» LLC
2009-08-01
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| Series: | Кардиоваскулярная терапия и профилактика |
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| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/1786 |
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| author | T. Sh. Mirilashvili S. V. Villewalde Yu. V. Kotovskaya Zh. D. Kobalava |
| author_facet | T. Sh. Mirilashvili S. V. Villewalde Yu. V. Kotovskaya Zh. D. Kobalava |
| author_sort | T. Sh. Mirilashvili |
| collection | DOAJ |
| description | Aim. To study the effects of an angiotensin II receptor antagonist (ARA II) valsartan, a statin (fluvastatin XL), and their combination on endothelial function (EF) in patients with arterial hypertension (AH) and dyslipidemia (DLP).Material and methods. In total, 30 patients with untreated, non-complicated Stage I-II AH and DLP IIA or IIB were randomised for 8-week monotherapy with valsartan or fluvastatin XL, with the subsequent addition of the second component, fluvastatin XL or valsartan, respectively.Results. Valsartan monotherapy was associated with a reduced increase in linear blood flow velocity (LFV) during the reactive hyperemia test (RHT) - 177,7+5,8 vs. 170,0+4,9% (p<0,01). At the same time, brachial artery endothelium-dependent vasodilatation (BA EDVD) increased by 14% (p>0,05). Eight-week monotherapy with fluvastatin XL (80 mg/d) was linked to moderate but statistically significant reduction (-2%) in systolic blood pressure (SBP), with no effect on diastolic BP level. In RHT, LFV increase did not change, but EF improved, as manifested in BA EDVD increase. Prolonged combined therapy resulted in further EF improvement.Conclusion. Combined fluvastatin XL and valsartan therapy in patients with untreated Stage I-II AH and DLP IIA or IIB improved EF more effectively than valsartan or fluvastatin XL monotherapy. |
| format | Article |
| id | doaj-art-0e0f32d3515340ecaee2a3f1abae732b |
| institution | Kabale University |
| issn | 1728-8800 2619-0125 |
| language | Russian |
| publishDate | 2009-08-01 |
| publisher | «SILICEA-POLIGRAF» LLC |
| record_format | Article |
| series | Кардиоваскулярная терапия и профилактика |
| spelling | doaj-art-0e0f32d3515340ecaee2a3f1abae732b2025-08-20T03:43:27Zrus«SILICEA-POLIGRAF» LLCКардиоваскулярная терапия и профилактика1728-88002619-01252009-08-018428321501Effects of fluvastatin, valsartan, and their combination on endothelial function in patients with arterial hypertension and dyslipidemiaT. Sh. Mirilashvili0S. V. Villewalde1Yu. V. Kotovskaya2Zh. D. Kobalava3Russian People’s Friendship University; City Clinical Hospital No. 64Russian People’s Friendship UniversityRussian People’s Friendship UniversityRussian People’s Friendship UniversityAim. To study the effects of an angiotensin II receptor antagonist (ARA II) valsartan, a statin (fluvastatin XL), and their combination on endothelial function (EF) in patients with arterial hypertension (AH) and dyslipidemia (DLP).Material and methods. In total, 30 patients with untreated, non-complicated Stage I-II AH and DLP IIA or IIB were randomised for 8-week monotherapy with valsartan or fluvastatin XL, with the subsequent addition of the second component, fluvastatin XL or valsartan, respectively.Results. Valsartan monotherapy was associated with a reduced increase in linear blood flow velocity (LFV) during the reactive hyperemia test (RHT) - 177,7+5,8 vs. 170,0+4,9% (p<0,01). At the same time, brachial artery endothelium-dependent vasodilatation (BA EDVD) increased by 14% (p>0,05). Eight-week monotherapy with fluvastatin XL (80 mg/d) was linked to moderate but statistically significant reduction (-2%) in systolic blood pressure (SBP), with no effect on diastolic BP level. In RHT, LFV increase did not change, but EF improved, as manifested in BA EDVD increase. Prolonged combined therapy resulted in further EF improvement.Conclusion. Combined fluvastatin XL and valsartan therapy in patients with untreated Stage I-II AH and DLP IIA or IIB improved EF more effectively than valsartan or fluvastatin XL monotherapy.https://cardiovascular.elpub.ru/jour/article/view/1786arterial hypertensiondyslipidemiaendothelial functionvalsartanfluvastatin xl |
| spellingShingle | T. Sh. Mirilashvili S. V. Villewalde Yu. V. Kotovskaya Zh. D. Kobalava Effects of fluvastatin, valsartan, and their combination on endothelial function in patients with arterial hypertension and dyslipidemia Кардиоваскулярная терапия и профилактика arterial hypertension dyslipidemia endothelial function valsartan fluvastatin xl |
| title | Effects of fluvastatin, valsartan, and their combination on endothelial function in patients with arterial hypertension and dyslipidemia |
| title_full | Effects of fluvastatin, valsartan, and their combination on endothelial function in patients with arterial hypertension and dyslipidemia |
| title_fullStr | Effects of fluvastatin, valsartan, and their combination on endothelial function in patients with arterial hypertension and dyslipidemia |
| title_full_unstemmed | Effects of fluvastatin, valsartan, and their combination on endothelial function in patients with arterial hypertension and dyslipidemia |
| title_short | Effects of fluvastatin, valsartan, and their combination on endothelial function in patients with arterial hypertension and dyslipidemia |
| title_sort | effects of fluvastatin valsartan and their combination on endothelial function in patients with arterial hypertension and dyslipidemia |
| topic | arterial hypertension dyslipidemia endothelial function valsartan fluvastatin xl |
| url | https://cardiovascular.elpub.ru/jour/article/view/1786 |
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