PreVenTB trial: protocol for evaluation of efficacy and safety of two vaccines VPM1002 and Immuvac (Mw) in preventing tuberculosis (TB) in healthy household contacts of newly diagnosed sputum smear-positive pulmonary TB patients: phase III, randomised, double-blind, three-arm placebo-controlled trial

PreVenTB trial: protocol for evaluation of efficacy and safety of two vaccines VPM1002 and Immuvac (Mw) in preventing tuberculosis (TB) in healthy household contacts of newly diagnosed sputum smear-positive pulmonary TB patients: phase III, randomised, double-blind, three-arm placebo-controlled trial

Introduction Tuberculosis (TB) continues to be one of the deadliest infectious diseases over the centuries, killing more people worldwide than any other single infectious disease. There is an urgent need for additional strategies which can expedite efforts to combat TB including a preventive vaccine...

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Main Authors: Raman R Gangakhedkar, Ravindra Mohan Pandey, Rakesh Kumar, Randeep Guleria, Manjula Singh, Soumya Swaminathan, George D’Souza, Rashmi Rodrigues, Anand Krishnan, Sanghamitra Pati, Sudipta Mohakud, Anant Mohan, Ramesh Kumar, Prasanta Raghab Mohapatra, Parul Kodan, Rohit Sarin, Baijayantimala Mishra, Geeta Yadav, Deepak Gupta, Anuj Bhatnagar, Sriram Selvaraju, Ritu Gupta, Sandeep Patil, Sourin Bhuniya, Sanjay Mehendale, Samiran Panda, Subrata Kumar Palo, Debasish Hota, Sangeeta Sharma, Srikanth Tripathy, Kiran Katoch, Sindhu Joshi, Somashekar Narasimhaiah, Sangeeta Bhaskar, Rajni Rani, Abdul Mabood Khan, Urvashi B Singh, D K Mitra, Neelam Roy, Amitva Sen Gupta, Vikram Vohra, Neeta Singla, Vijaya Valluri Ansari, Chitra Iravatham, Shilpa Rakh, D K Prudhula, Chala Devi, N Rupa, K Sailaja, Sheela Godbole, Seema Sahay, Suchit Kamble, Megha Mamulwar, Arati Kishor Mane, Ashwini Vinod Shete, Abhijit Vasantrao Kadam, Vineet Chadha, S Uma Shankar, C Ravichandra, S K Tripathy, Dasarathi Das, Tahziba Hussain, B Dwibedi, P R Mohapatra, S C B Cuttack, M R Pattnaik, Sabita Mohapatra, Banu Rekha, Mohan Natarajan, P K Bhavani, D Bella Devaleenal, Syed Hisar, S Devarajulu Reddy, Paul Kumaran, Makhesh Kumar, Poorna Ganga Devi, Sunny Omkar Singh, Devi Pratyush, Vidushi Gupta, Parvathi
Format: Article
Language:English
Published: BMJ Publishing Group 2024-08-01
Series:BMJ Open
Online Access:https://bmjopen.bmj.com/content/14/8/e082916.full
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