The differential role of aryl hydrocarbon receptor in skin cancers induced by environmental carcinogens, including ultraviolet irradiation, arsenic exposure, and HPV infection
The skin functions as the primary barrier organ in humans, safeguarding against environmental insults and challenges. Continuous skin turnover and effective immunosurveillance are critical for maintaining skin homeostasis and preventing the development of skin cancers induced by physical (ultraviole...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2025-01-01
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| Series: | Dermatologica Sinica |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/ds.DS-D-24-00092 |
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| Summary: | The skin functions as the primary barrier organ in humans, safeguarding against environmental insults and challenges. Continuous skin turnover and effective immunosurveillance are critical for maintaining skin homeostasis and preventing the development of skin cancers induced by physical (ultraviolet [UV] irradiation), chemical (arsenic and polycyclic aromatic hydrocarbons [PAHs]), and biological (human papillomavirus [HPV] infection) agents. The aryl hydrocarbon receptor (AhR) is a ubiquitous cellular environmental sensor that regulates numerous biological processes, including cellular differentiation and immune regulation, key mechanisms in the defense against skin carcinogenesis. Although many studies have elucidated the role of AhR in mediating the biological and immunological effects of UV and PAH in skin carcinogenesis and inflammation, relatively few studies have investigated the involvement of AhR in skin carcinogenesis induced by arsenic and HPV, two well-characterized skin carcinogens distinct from PAH. This review aims to summarize the current evidence regarding the role of AhR in regulating skin carcinogenesis and modulating immunosurveillance or inflammatory responses in the context of skin cancer induced by these exogenous insults. |
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| ISSN: | 1027-8117 2223-330X |