Slick potassium channels limit TRPM3-mediated activation of sensory neurons

Slick potassium channels limit TRPM3-mediated activation of sensory neurons

Heat sensation is mediated by specialized heat-sensitive neurons in the somatosensory system that innervates the skin. Previous studies revealed that noxious heat sensation is controlled by the sodium (Na+)-activated potassium (K+) channel Slick (Kcnt2), which is highly expressed in nociceptive Aδ-f...

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Bibliographic Details
Main Authors: Patrick Engel, Fangyuan Zhou, Bang Tam Thi Tran, Achim Schmidtko, Ruirui Lu
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Pharmacology
Subjects:
heat nociception
TRPM3
Slick
sensory neurons
potassium current
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1459735/full
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