Gut microbiota: A new window for the prevention and treatment of neuropsychiatric disease
Under normal physiological conditions, gut microbiota and host mutually coexist. They play key roles in maintaining intestinal barrier integrity, absorption, and metabolism, as well as promoting the development of the central nervous system (CNS) and emotional regulation. The dysregulation of gut mi...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2025-02-01
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| Series: | Journal of Central Nervous System Disease |
| Online Access: | https://doi.org/10.1177/11795735251322450 |
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| _version_ | 1850191484833234944 |
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| author | Yali Tang Yizhu Zhang Chen Chen Ying Cao Qiaona Wang Chuanfeng Tang |
| author_facet | Yali Tang Yizhu Zhang Chen Chen Ying Cao Qiaona Wang Chuanfeng Tang |
| author_sort | Yali Tang |
| collection | DOAJ |
| description | Under normal physiological conditions, gut microbiota and host mutually coexist. They play key roles in maintaining intestinal barrier integrity, absorption, and metabolism, as well as promoting the development of the central nervous system (CNS) and emotional regulation. The dysregulation of gut microbiota homeostasis has attracted significant research interest, specifically in its impact on neurological and psychiatric disorders. Recent studies have highlighted the important role of the gut- brain axis in conditions including Alzheimer’s Disease (AD), Parkinson’s Disease (PD), and depression. This review aims to elucidate the regulatory mechanisms by which gut microbiota affect the progression of CNS disorders via the gut-brain axis. Additionally, we discuss the current research landscape, identify gaps, and propose future directions for microbial interventions against these diseases. Finally, we provide a theoretical reference for clinical treatment strategies and drug development for AD, PD, and depression. |
| format | Article |
| id | doaj-art-0df9ae2894044abaab86805c2eb27360 |
| institution | OA Journals |
| issn | 1179-5735 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Central Nervous System Disease |
| spelling | doaj-art-0df9ae2894044abaab86805c2eb273602025-08-20T02:14:54ZengSAGE PublishingJournal of Central Nervous System Disease1179-57352025-02-011710.1177/11795735251322450Gut microbiota: A new window for the prevention and treatment of neuropsychiatric diseaseYali TangYizhu ZhangChen ChenYing CaoQiaona WangChuanfeng TangUnder normal physiological conditions, gut microbiota and host mutually coexist. They play key roles in maintaining intestinal barrier integrity, absorption, and metabolism, as well as promoting the development of the central nervous system (CNS) and emotional regulation. The dysregulation of gut microbiota homeostasis has attracted significant research interest, specifically in its impact on neurological and psychiatric disorders. Recent studies have highlighted the important role of the gut- brain axis in conditions including Alzheimer’s Disease (AD), Parkinson’s Disease (PD), and depression. This review aims to elucidate the regulatory mechanisms by which gut microbiota affect the progression of CNS disorders via the gut-brain axis. Additionally, we discuss the current research landscape, identify gaps, and propose future directions for microbial interventions against these diseases. Finally, we provide a theoretical reference for clinical treatment strategies and drug development for AD, PD, and depression.https://doi.org/10.1177/11795735251322450 |
| spellingShingle | Yali Tang Yizhu Zhang Chen Chen Ying Cao Qiaona Wang Chuanfeng Tang Gut microbiota: A new window for the prevention and treatment of neuropsychiatric disease Journal of Central Nervous System Disease |
| title | Gut microbiota: A new window for the prevention and treatment of neuropsychiatric disease |
| title_full | Gut microbiota: A new window for the prevention and treatment of neuropsychiatric disease |
| title_fullStr | Gut microbiota: A new window for the prevention and treatment of neuropsychiatric disease |
| title_full_unstemmed | Gut microbiota: A new window for the prevention and treatment of neuropsychiatric disease |
| title_short | Gut microbiota: A new window for the prevention and treatment of neuropsychiatric disease |
| title_sort | gut microbiota a new window for the prevention and treatment of neuropsychiatric disease |
| url | https://doi.org/10.1177/11795735251322450 |
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