Multiple Molecular Targets Associated with Genomic Instability in Lung Cancer
Lung cancer (LC) is the first cause of cancer-related deaths worldwide. Elucidating the pathogenesis of LC will give information on key elements of tumor initiation and development while helping to design novel targeted therapies. LC is an heterogeneous disease that has the second highest mutation r...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-01-01
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| Series: | International Journal of Genomics |
| Online Access: | http://dx.doi.org/10.1155/2019/9584504 |
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| _version_ | 1849308470009921536 |
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| author | Giovanny Soca-Chafre Angelica Montiel-Dávalos Inti Alberto De La Rosa-Velázquez Claudia Haydeé Saraí Caro-Sánchez Adriana Peña-Nieves Oscar Arrieta |
| author_facet | Giovanny Soca-Chafre Angelica Montiel-Dávalos Inti Alberto De La Rosa-Velázquez Claudia Haydeé Saraí Caro-Sánchez Adriana Peña-Nieves Oscar Arrieta |
| author_sort | Giovanny Soca-Chafre |
| collection | DOAJ |
| description | Lung cancer (LC) is the first cause of cancer-related deaths worldwide. Elucidating the pathogenesis of LC will give information on key elements of tumor initiation and development while helping to design novel targeted therapies. LC is an heterogeneous disease that has the second highest mutation rate surpassed only by melanoma, since 90% of LC occurs in tobacco smokers. However, only a small percent of smokers develops LC, indicating an inherent genomic instability. Additionally, LC in never smokers suggests other molecular mechanisms not causally linked to tobacco carcinogens. This review presents a current outlook of the connection between LC and genomic instability at the molecular and clinical level summarizing its implications for diagnosis, therapy, and prognosis. The genomic landscape of LC shows widespread alterations such as DNA methylation, point mutations, copy number variation, chromosomal translocations, and aneuploidy. Genome maintenance mechanisms including cell cycle control, DNA repair, and mitotic checkpoints open a window to translational research for finding novel diagnostic biomarkers and targeted therapies in LC. |
| format | Article |
| id | doaj-art-0df7f2bc44d5433cb346c056fcea7ff4 |
| institution | Kabale University |
| issn | 2314-436X 2314-4378 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Genomics |
| spelling | doaj-art-0df7f2bc44d5433cb346c056fcea7ff42025-08-20T03:54:28ZengWileyInternational Journal of Genomics2314-436X2314-43782019-01-01201910.1155/2019/95845049584504Multiple Molecular Targets Associated with Genomic Instability in Lung CancerGiovanny Soca-Chafre0Angelica Montiel-Dávalos1Inti Alberto De La Rosa-Velázquez2Claudia Haydeé Saraí Caro-Sánchez3Adriana Peña-Nieves4Oscar Arrieta5Personalized Medicine Laboratory, Instituto Nacional de Cancerología (INCAN), MexicoBasic Research Division, Instituto Nacional de Cancerología (INCAN), MexicoGenomics Laboratory, Instituto Nacional de Ciencias Médicas y Nutrición, MexicoDepartment of Pathology, Instituto Nacional de Cancerología (INCAN), MexicoPalliative Care Unit, Instituto Nacional de Cancerología, México City, MexicoPersonalized Medicine Laboratory, Instituto Nacional de Cancerología (INCAN), MexicoLung cancer (LC) is the first cause of cancer-related deaths worldwide. Elucidating the pathogenesis of LC will give information on key elements of tumor initiation and development while helping to design novel targeted therapies. LC is an heterogeneous disease that has the second highest mutation rate surpassed only by melanoma, since 90% of LC occurs in tobacco smokers. However, only a small percent of smokers develops LC, indicating an inherent genomic instability. Additionally, LC in never smokers suggests other molecular mechanisms not causally linked to tobacco carcinogens. This review presents a current outlook of the connection between LC and genomic instability at the molecular and clinical level summarizing its implications for diagnosis, therapy, and prognosis. The genomic landscape of LC shows widespread alterations such as DNA methylation, point mutations, copy number variation, chromosomal translocations, and aneuploidy. Genome maintenance mechanisms including cell cycle control, DNA repair, and mitotic checkpoints open a window to translational research for finding novel diagnostic biomarkers and targeted therapies in LC.http://dx.doi.org/10.1155/2019/9584504 |
| spellingShingle | Giovanny Soca-Chafre Angelica Montiel-Dávalos Inti Alberto De La Rosa-Velázquez Claudia Haydeé Saraí Caro-Sánchez Adriana Peña-Nieves Oscar Arrieta Multiple Molecular Targets Associated with Genomic Instability in Lung Cancer International Journal of Genomics |
| title | Multiple Molecular Targets Associated with Genomic Instability in Lung Cancer |
| title_full | Multiple Molecular Targets Associated with Genomic Instability in Lung Cancer |
| title_fullStr | Multiple Molecular Targets Associated with Genomic Instability in Lung Cancer |
| title_full_unstemmed | Multiple Molecular Targets Associated with Genomic Instability in Lung Cancer |
| title_short | Multiple Molecular Targets Associated with Genomic Instability in Lung Cancer |
| title_sort | multiple molecular targets associated with genomic instability in lung cancer |
| url | http://dx.doi.org/10.1155/2019/9584504 |
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