Apixaban as a Rare Cause of Leukocytoclastic Vasculitis

Apixaban is a rare cause of leukocytoclastic vasculitis (LCV). To our knowledge, there is only one other reported case due to apixaban in the literature. We present a case of apixaban-induced leukocytoclastic vasculitis in a 95-year-old male. He had been started on apixaban 12 days prior to presenta...

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Main Authors: Jenna Spears, David Alexandre Chetrit, Sina Manthey, Christopher Lee, Yousif Al-Saiegh
Format: Article
Language:English
Published: Wiley 2020-01-01
Series:Case Reports in Rheumatology
Online Access:http://dx.doi.org/10.1155/2020/7234069
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author Jenna Spears
David Alexandre Chetrit
Sina Manthey
Christopher Lee
Yousif Al-Saiegh
author_facet Jenna Spears
David Alexandre Chetrit
Sina Manthey
Christopher Lee
Yousif Al-Saiegh
author_sort Jenna Spears
collection DOAJ
description Apixaban is a rare cause of leukocytoclastic vasculitis (LCV). To our knowledge, there is only one other reported case due to apixaban in the literature. We present a case of apixaban-induced leukocytoclastic vasculitis in a 95-year-old male. He had been started on apixaban 12 days prior to presentation and developed worsening palpable purpura of his lower extremities. Possible etiologies of this new rash were excluded, with biopsy showing extensive purpura with superficial perivascular neutrophilic infiltrate and leukocytoclasis. Apixaban was discontinued, and the patient was started on a slow prednisone taper with subsequent resolution of his rash.
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spelling doaj-art-0dece0758fbc4f5e86c99691269c46aa2025-08-20T03:55:33ZengWileyCase Reports in Rheumatology2090-68892090-68972020-01-01202010.1155/2020/72340697234069Apixaban as a Rare Cause of Leukocytoclastic VasculitisJenna Spears0David Alexandre Chetrit1Sina Manthey2Christopher Lee3Yousif Al-Saiegh4Department of Medicine, Pennsylvania Hospital, University of Pennsylvania Health System (UPHS), Philadelphia, PA, USADepartment of Medicine, Pennsylvania Hospital, University of Pennsylvania Health System (UPHS), Philadelphia, PA, USADepartment of Medicine, Pennsylvania Hospital, University of Pennsylvania Health System (UPHS), Philadelphia, PA, USADepartment of Medicine, Pennsylvania Hospital, University of Pennsylvania Health System (UPHS), Philadelphia, PA, USADepartment of Medicine, Pennsylvania Hospital, University of Pennsylvania Health System (UPHS), Philadelphia, PA, USAApixaban is a rare cause of leukocytoclastic vasculitis (LCV). To our knowledge, there is only one other reported case due to apixaban in the literature. We present a case of apixaban-induced leukocytoclastic vasculitis in a 95-year-old male. He had been started on apixaban 12 days prior to presentation and developed worsening palpable purpura of his lower extremities. Possible etiologies of this new rash were excluded, with biopsy showing extensive purpura with superficial perivascular neutrophilic infiltrate and leukocytoclasis. Apixaban was discontinued, and the patient was started on a slow prednisone taper with subsequent resolution of his rash.http://dx.doi.org/10.1155/2020/7234069
spellingShingle Jenna Spears
David Alexandre Chetrit
Sina Manthey
Christopher Lee
Yousif Al-Saiegh
Apixaban as a Rare Cause of Leukocytoclastic Vasculitis
Case Reports in Rheumatology
title Apixaban as a Rare Cause of Leukocytoclastic Vasculitis
title_full Apixaban as a Rare Cause of Leukocytoclastic Vasculitis
title_fullStr Apixaban as a Rare Cause of Leukocytoclastic Vasculitis
title_full_unstemmed Apixaban as a Rare Cause of Leukocytoclastic Vasculitis
title_short Apixaban as a Rare Cause of Leukocytoclastic Vasculitis
title_sort apixaban as a rare cause of leukocytoclastic vasculitis
url http://dx.doi.org/10.1155/2020/7234069
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