Frequency of Macroprolactinemia in Hyperprolactinemic Women Presenting with Menstrual Irregularities, Galactorrhea, and/or Infertility: Etiology and Clinical Manifestations
Aim. To determine the frequency of macroprolactinemia, its etiology, and the clinical manifestations in patients with hyperprolactinemia presenting with menstrual irregularities, galactorrhea, and/or infertility who were attended by the gynecology-endocrinology service. Methods. In a cross-sectional...
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Wiley
2013-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2013/478282 |
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| author | Alfredo Leaños-Miranda Karla Leticia Ramírez-Valenzuela Inova Campos-Galicia Rosario Chang-Verdugo Lizbeth Zarela Chinolla-Arellano |
| author_facet | Alfredo Leaños-Miranda Karla Leticia Ramírez-Valenzuela Inova Campos-Galicia Rosario Chang-Verdugo Lizbeth Zarela Chinolla-Arellano |
| author_sort | Alfredo Leaños-Miranda |
| collection | DOAJ |
| description | Aim. To determine the frequency of macroprolactinemia, its etiology, and the clinical manifestations in patients with hyperprolactinemia presenting with menstrual irregularities, galactorrhea, and/or infertility who were attended by the gynecology-endocrinology service. Methods. In a cross-sectional study, 326 hyperprolactinemic women were tested for serum prolactin (PRL) concentrations before and after chromatographic separation (gel filtration and affinity with protein G) and extraction of free PRL with polyethylene glycol (PEG). Results. Sera from 57 patients (17.5%) were found to have macroprolactinemia. The presence of macroprolactinemia was attributable to anti-PRL autoantibodies in 54 (94.7%) patients. The median serum PRL levels were similar in patients with or without macroprolactinemia (42.0 versus 38.1 ng/mL). In contrast, patients with macroprolactinemia had lower serum-free PRL levels (median 9.2 versus 31.7 ng/mL, ). Patients without macroprolactinemia had a higher frequency of galactorrhea and abnormal pituitary imagine findings (). Conclusions. We can conclude that macroprolactinemia should be considered as a benign variant, and it must be ruled out in women presenting with menstrual irregularities, galactorrhea, and/or infertility in order to investigate other causes different than hyperprolactinemia. Serum PRL precipitated with PEG is a convenient and simple procedure to screen for the presence of macroprolactinemia. |
| format | Article |
| id | doaj-art-0deaa001b6ea4c918b8263e6b277e16b |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-0deaa001b6ea4c918b8263e6b277e16b2025-08-20T03:55:33ZengWileyInternational Journal of Endocrinology1687-83371687-83452013-01-01201310.1155/2013/478282478282Frequency of Macroprolactinemia in Hyperprolactinemic Women Presenting with Menstrual Irregularities, Galactorrhea, and/or Infertility: Etiology and Clinical ManifestationsAlfredo Leaños-Miranda0Karla Leticia Ramírez-Valenzuela1Inova Campos-Galicia2Rosario Chang-Verdugo3Lizbeth Zarela Chinolla-Arellano4Research Unit in Reproductive Medicine, Unidad Médica de Alta Especialidad, Hospital de Ginecología y Obstetricia, Luis Castelazo Ayala, Instituto Mexicano del Seguro Social, Don Luis No. 111, Col. Nativitas, 03500 México, DF, MexicoResearch Unit in Reproductive Medicine, Unidad Médica de Alta Especialidad, Hospital de Ginecología y Obstetricia, Luis Castelazo Ayala, Instituto Mexicano del Seguro Social, Don Luis No. 111, Col. Nativitas, 03500 México, DF, MexicoResearch Unit in Reproductive Medicine, Unidad Médica de Alta Especialidad, Hospital de Ginecología y Obstetricia, Luis Castelazo Ayala, Instituto Mexicano del Seguro Social, Don Luis No. 111, Col. Nativitas, 03500 México, DF, MexicoClinical Laboratory, Unidad Médica de Alta Especialidad, Hospital de Ginecología y Obstetricia, Luis Castelazo Ayala, Instituto Mexicano del Seguro Social, México, DF, MexicoResearch Unit in Reproductive Medicine, Unidad Médica de Alta Especialidad, Hospital de Ginecología y Obstetricia, Luis Castelazo Ayala, Instituto Mexicano del Seguro Social, Don Luis No. 111, Col. Nativitas, 03500 México, DF, MexicoAim. To determine the frequency of macroprolactinemia, its etiology, and the clinical manifestations in patients with hyperprolactinemia presenting with menstrual irregularities, galactorrhea, and/or infertility who were attended by the gynecology-endocrinology service. Methods. In a cross-sectional study, 326 hyperprolactinemic women were tested for serum prolactin (PRL) concentrations before and after chromatographic separation (gel filtration and affinity with protein G) and extraction of free PRL with polyethylene glycol (PEG). Results. Sera from 57 patients (17.5%) were found to have macroprolactinemia. The presence of macroprolactinemia was attributable to anti-PRL autoantibodies in 54 (94.7%) patients. The median serum PRL levels were similar in patients with or without macroprolactinemia (42.0 versus 38.1 ng/mL). In contrast, patients with macroprolactinemia had lower serum-free PRL levels (median 9.2 versus 31.7 ng/mL, ). Patients without macroprolactinemia had a higher frequency of galactorrhea and abnormal pituitary imagine findings (). Conclusions. We can conclude that macroprolactinemia should be considered as a benign variant, and it must be ruled out in women presenting with menstrual irregularities, galactorrhea, and/or infertility in order to investigate other causes different than hyperprolactinemia. Serum PRL precipitated with PEG is a convenient and simple procedure to screen for the presence of macroprolactinemia.http://dx.doi.org/10.1155/2013/478282 |
| spellingShingle | Alfredo Leaños-Miranda Karla Leticia Ramírez-Valenzuela Inova Campos-Galicia Rosario Chang-Verdugo Lizbeth Zarela Chinolla-Arellano Frequency of Macroprolactinemia in Hyperprolactinemic Women Presenting with Menstrual Irregularities, Galactorrhea, and/or Infertility: Etiology and Clinical Manifestations International Journal of Endocrinology |
| title | Frequency of Macroprolactinemia in Hyperprolactinemic Women Presenting with Menstrual Irregularities, Galactorrhea, and/or Infertility: Etiology and Clinical Manifestations |
| title_full | Frequency of Macroprolactinemia in Hyperprolactinemic Women Presenting with Menstrual Irregularities, Galactorrhea, and/or Infertility: Etiology and Clinical Manifestations |
| title_fullStr | Frequency of Macroprolactinemia in Hyperprolactinemic Women Presenting with Menstrual Irregularities, Galactorrhea, and/or Infertility: Etiology and Clinical Manifestations |
| title_full_unstemmed | Frequency of Macroprolactinemia in Hyperprolactinemic Women Presenting with Menstrual Irregularities, Galactorrhea, and/or Infertility: Etiology and Clinical Manifestations |
| title_short | Frequency of Macroprolactinemia in Hyperprolactinemic Women Presenting with Menstrual Irregularities, Galactorrhea, and/or Infertility: Etiology and Clinical Manifestations |
| title_sort | frequency of macroprolactinemia in hyperprolactinemic women presenting with menstrual irregularities galactorrhea and or infertility etiology and clinical manifestations |
| url | http://dx.doi.org/10.1155/2013/478282 |
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