Excitatory-inhibitory homeostasis and bifurcation control in the Wilson-Cowan model of cortical dynamics.
Although the primary function of excitatory-inhibitory (E-I) homeostasis is the maintenance of mean firing rates, the conjugation of multiple homeostatic mechanisms is thought to be pivotal to ensuring edge-of-bifurcation dynamics in cortical circuits. However, computational studies on E-I homeostas...
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Public Library of Science (PLoS)
2025-01-01
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| Series: | PLoS Computational Biology |
| Online Access: | https://doi.org/10.1371/journal.pcbi.1012723 |
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| author | Francisco Páscoa Dos Santos Paul F M J Verschure |
| author_facet | Francisco Páscoa Dos Santos Paul F M J Verschure |
| author_sort | Francisco Páscoa Dos Santos |
| collection | DOAJ |
| description | Although the primary function of excitatory-inhibitory (E-I) homeostasis is the maintenance of mean firing rates, the conjugation of multiple homeostatic mechanisms is thought to be pivotal to ensuring edge-of-bifurcation dynamics in cortical circuits. However, computational studies on E-I homeostasis have focused solely on the plasticity of inhibition, neglecting the impact of different modes of E-I homeostasis on cortical dynamics. Therefore, we investigate how the diverse mechanisms of E-I homeostasis employed by cortical networks shape oscillations and edge-of-bifurcation dynamics. Using the Wilson-Cowan model, we explore how distinct modes of E-I homeostasis maintain stable firing rates in models with varying levels of input and how it affects circuit dynamics. Our results confirm that E-I homeostasis can be leveraged to control edge-of-bifurcation dynamics and that some modes of homeostasis maintain mean firing rates under higher levels of input by modulating the distance to the bifurcation. Additionally, relying on multiple modes of homeostasis ensures stable activity while keeping oscillation frequencies within a physiological range. Our findings tie relevant features of cortical networks, such as E-I balance, the generation of gamma oscillations, and edge-of-bifurcation dynamics, under the framework of firing-rate homeostasis, providing a mechanistic explanation for the heterogeneity in the distance to the bifurcation found across cortical areas. In addition, we reveal the functional benefits of relying upon different homeostatic mechanisms, providing a robust method to regulate network dynamics with minimal perturbation to the generation of gamma rhythms and explaining the correlation between inhibition and gamma frequencies found in cortical networks. |
| format | Article |
| id | doaj-art-0de804cbbbba485f9447e26d1cf8b59a |
| institution | Kabale University |
| issn | 1553-734X 1553-7358 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS Computational Biology |
| spelling | doaj-art-0de804cbbbba485f9447e26d1cf8b59a2025-02-05T05:30:39ZengPublic Library of Science (PLoS)PLoS Computational Biology1553-734X1553-73582025-01-01211e101272310.1371/journal.pcbi.1012723Excitatory-inhibitory homeostasis and bifurcation control in the Wilson-Cowan model of cortical dynamics.Francisco Páscoa Dos SantosPaul F M J VerschureAlthough the primary function of excitatory-inhibitory (E-I) homeostasis is the maintenance of mean firing rates, the conjugation of multiple homeostatic mechanisms is thought to be pivotal to ensuring edge-of-bifurcation dynamics in cortical circuits. However, computational studies on E-I homeostasis have focused solely on the plasticity of inhibition, neglecting the impact of different modes of E-I homeostasis on cortical dynamics. Therefore, we investigate how the diverse mechanisms of E-I homeostasis employed by cortical networks shape oscillations and edge-of-bifurcation dynamics. Using the Wilson-Cowan model, we explore how distinct modes of E-I homeostasis maintain stable firing rates in models with varying levels of input and how it affects circuit dynamics. Our results confirm that E-I homeostasis can be leveraged to control edge-of-bifurcation dynamics and that some modes of homeostasis maintain mean firing rates under higher levels of input by modulating the distance to the bifurcation. Additionally, relying on multiple modes of homeostasis ensures stable activity while keeping oscillation frequencies within a physiological range. Our findings tie relevant features of cortical networks, such as E-I balance, the generation of gamma oscillations, and edge-of-bifurcation dynamics, under the framework of firing-rate homeostasis, providing a mechanistic explanation for the heterogeneity in the distance to the bifurcation found across cortical areas. In addition, we reveal the functional benefits of relying upon different homeostatic mechanisms, providing a robust method to regulate network dynamics with minimal perturbation to the generation of gamma rhythms and explaining the correlation between inhibition and gamma frequencies found in cortical networks.https://doi.org/10.1371/journal.pcbi.1012723 |
| spellingShingle | Francisco Páscoa Dos Santos Paul F M J Verschure Excitatory-inhibitory homeostasis and bifurcation control in the Wilson-Cowan model of cortical dynamics. PLoS Computational Biology |
| title | Excitatory-inhibitory homeostasis and bifurcation control in the Wilson-Cowan model of cortical dynamics. |
| title_full | Excitatory-inhibitory homeostasis and bifurcation control in the Wilson-Cowan model of cortical dynamics. |
| title_fullStr | Excitatory-inhibitory homeostasis and bifurcation control in the Wilson-Cowan model of cortical dynamics. |
| title_full_unstemmed | Excitatory-inhibitory homeostasis and bifurcation control in the Wilson-Cowan model of cortical dynamics. |
| title_short | Excitatory-inhibitory homeostasis and bifurcation control in the Wilson-Cowan model of cortical dynamics. |
| title_sort | excitatory inhibitory homeostasis and bifurcation control in the wilson cowan model of cortical dynamics |
| url | https://doi.org/10.1371/journal.pcbi.1012723 |
| work_keys_str_mv | AT franciscopascoadossantos excitatoryinhibitoryhomeostasisandbifurcationcontrolinthewilsoncowanmodelofcorticaldynamics AT paulfmjverschure excitatoryinhibitoryhomeostasisandbifurcationcontrolinthewilsoncowanmodelofcorticaldynamics |