Distinct Virologic Properties of African and Epidemic Zika Virus Strains: The Role of the Envelope Protein in Viral Entry, Immune Activation, and Neuropathogenesis

Distinct Virologic Properties of African and Epidemic Zika Virus Strains: The Role of the Envelope Protein in Viral Entry, Immune Activation, and Neuropathogenesis

The 2016 Zika virus (ZIKV) epidemic has largely subsided, but a key question remains. How did ZIKV evolve to become a virulent human pathogen compared to the virus of its original discovery? What specific virologic and pathologic changes contributed to increased pathogenicity in humans? Phylogenetic...

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Bibliographic Details
Main Authors: Ashkan Roozitalab, Chenyu Zhang, Jiantao Zhang, Ge Li, Chengyu Yang, Wangheng Hou, Qiyi Tang, Richard Y. Zhao
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Pathogens
Subjects:
Zika virus (ZIKV)
envelope (E) protein
African lineage
Asian lineage
human neural progenitor cell (hNPC)-derived neurosphere
viral entry
Online Access:https://www.mdpi.com/2076-0817/14/7/716
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