Congenital Heart Diseases: Recent Insights into Epigenetic Mechanisms

Congenital Heart Diseases: Recent Insights into Epigenetic Mechanisms

Congenital Heart Diseases (CHDs) are a heterogeneous group of structural abnormalities affecting the heart and major arteries, which are present in at least 1% of births worldwide. Studies have linked CHD to both genetic and environmental factors. In this regard, it has been demonstrated that change...

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Main Authors: José Manuel Rodríguez-Pérez, Diego B. Ortega-Zhindón, Clara Villamil-Castañeda, Javier Santiago Lara-Ortiz, Verónica Marusa Borgonio-Cuadra, Jorge L. Cervantes-Salazar, Juan Calderón-Colmenero, Zeomara Nathali Escalante-Ruiz, Eduardo Retama-Méndez, Yessica C. Hernández-García, Nonanzit Pérez-Hernández
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Cells
Subjects:
congenital heart diseases
epigenetics
DNA methylation
histone modifications
polycomb and trithorax protein complexes
non-coding RNAs
Online Access:https://www.mdpi.com/2073-4409/14/11/820
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Summary:Congenital Heart Diseases (CHDs) are a heterogeneous group of structural abnormalities affecting the heart and major arteries, which are present in at least 1% of births worldwide. Studies have linked CHD to both genetic and environmental factors. In this regard, it has been demonstrated that changes in the epigenetic pattern impact the expression of key genes involved in proper cardiac development. Therefore, it is suggested that aberrant epigenetic mechanisms may contribute to the development of these pathologies. Here, we review and summarize the main epigenetic mechanisms involved in CHD. Moreover, cardiac development and the importance of the environment and CHD are also addressed.
ISSN:2073-4409

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