Effects of Neuropeptide Y on Stem Cells and Their Potential Applications in Disease Therapy
Neuropeptide Y (NPY), a 36-amino acid peptide, is widely distributed in the central and peripheral nervous systems and other peripheral tissues. It takes part in regulating various biological processes including food intake, circadian rhythm, energy metabolism, and neuroendocrine secretion. Increasi...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2017-01-01
|
| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2017/6823917 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850235006505451520 |
|---|---|
| author | Song Peng You-li Zhou Zhi-yuan Song Shu Lin |
| author_facet | Song Peng You-li Zhou Zhi-yuan Song Shu Lin |
| author_sort | Song Peng |
| collection | DOAJ |
| description | Neuropeptide Y (NPY), a 36-amino acid peptide, is widely distributed in the central and peripheral nervous systems and other peripheral tissues. It takes part in regulating various biological processes including food intake, circadian rhythm, energy metabolism, and neuroendocrine secretion. Increasing evidence indicates that NPY exerts multiple regulatory effects on stem cells. As a kind of primitive and undifferentiated cells, stem cells have the therapeutic potential to replace damaged cells, secret paracrine molecules, promote angiogenesis, and modulate immunity. Stem cell-based therapy has been demonstrated effective and considered as one of the most promising treatments for specific diseases. However, several limitations still hamper its application, such as poor survival and low differentiation and integration rates of transplanted stem cells. The regulatory effects of NPY on stem cell survival, proliferation, and differentiation may be helpful to overcome these limitations and facilitate the application of stem cell-based therapy. In this review, we summarized the regulatory effects of NPY on stem cells and discussed their potential applications in disease therapy. |
| format | Article |
| id | doaj-art-0ddfff200b554ddf9dd447557b5e1b8f |
| institution | OA Journals |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-0ddfff200b554ddf9dd447557b5e1b8f2025-08-20T02:02:26ZengWileyStem Cells International1687-966X1687-96782017-01-01201710.1155/2017/68239176823917Effects of Neuropeptide Y on Stem Cells and Their Potential Applications in Disease TherapySong Peng0You-li Zhou1Zhi-yuan Song2Shu Lin3Department of Cardiology, Southwest Hospital, Third Military Medical University, Chongqing, ChinaDepartment of Cardiology, Southwest Hospital, Third Military Medical University, Chongqing, ChinaDepartment of Cardiology, Southwest Hospital, Third Military Medical University, Chongqing, ChinaDepartment of Cardiology, Southwest Hospital, Third Military Medical University, Chongqing, ChinaNeuropeptide Y (NPY), a 36-amino acid peptide, is widely distributed in the central and peripheral nervous systems and other peripheral tissues. It takes part in regulating various biological processes including food intake, circadian rhythm, energy metabolism, and neuroendocrine secretion. Increasing evidence indicates that NPY exerts multiple regulatory effects on stem cells. As a kind of primitive and undifferentiated cells, stem cells have the therapeutic potential to replace damaged cells, secret paracrine molecules, promote angiogenesis, and modulate immunity. Stem cell-based therapy has been demonstrated effective and considered as one of the most promising treatments for specific diseases. However, several limitations still hamper its application, such as poor survival and low differentiation and integration rates of transplanted stem cells. The regulatory effects of NPY on stem cell survival, proliferation, and differentiation may be helpful to overcome these limitations and facilitate the application of stem cell-based therapy. In this review, we summarized the regulatory effects of NPY on stem cells and discussed their potential applications in disease therapy.http://dx.doi.org/10.1155/2017/6823917 |
| spellingShingle | Song Peng You-li Zhou Zhi-yuan Song Shu Lin Effects of Neuropeptide Y on Stem Cells and Their Potential Applications in Disease Therapy Stem Cells International |
| title | Effects of Neuropeptide Y on Stem Cells and Their Potential Applications in Disease Therapy |
| title_full | Effects of Neuropeptide Y on Stem Cells and Their Potential Applications in Disease Therapy |
| title_fullStr | Effects of Neuropeptide Y on Stem Cells and Their Potential Applications in Disease Therapy |
| title_full_unstemmed | Effects of Neuropeptide Y on Stem Cells and Their Potential Applications in Disease Therapy |
| title_short | Effects of Neuropeptide Y on Stem Cells and Their Potential Applications in Disease Therapy |
| title_sort | effects of neuropeptide y on stem cells and their potential applications in disease therapy |
| url | http://dx.doi.org/10.1155/2017/6823917 |
| work_keys_str_mv | AT songpeng effectsofneuropeptideyonstemcellsandtheirpotentialapplicationsindiseasetherapy AT youlizhou effectsofneuropeptideyonstemcellsandtheirpotentialapplicationsindiseasetherapy AT zhiyuansong effectsofneuropeptideyonstemcellsandtheirpotentialapplicationsindiseasetherapy AT shulin effectsofneuropeptideyonstemcellsandtheirpotentialapplicationsindiseasetherapy |