Immune Evasion Strategies of Pre-Erythrocytic Malaria Parasites
Malaria is a mosquito-borne infectious disease of humans. It begins with a bite from an infected female Anopheles mosquito and leads to the development of the pre-erythrocytic and blood stages. Blood-stage infection is the exclusive cause of clinical symptoms of malaria. In contrast, the pre-erythro...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2014/362605 |
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| _version_ | 1832564590219624448 |
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| author | Hong Zheng Zhangping Tan Wenyue Xu |
| author_facet | Hong Zheng Zhangping Tan Wenyue Xu |
| author_sort | Hong Zheng |
| collection | DOAJ |
| description | Malaria is a mosquito-borne infectious disease of humans. It begins with a bite from an infected female Anopheles mosquito and leads to the development of the pre-erythrocytic and blood stages. Blood-stage infection is the exclusive cause of clinical symptoms of malaria. In contrast, the pre-erythrocytic stage is clinically asymptomatic and could be an excellent target for preventive therapies. Although the robust host immune responses limit the development of the liver stage, malaria parasites have also evolved strategies to suppress host defenses at the pre-erythrocytic stage. This paper reviews the immune evasion strategies of malaria parasites at the pre-erythrocytic stage, which could provide us with potential targets to design prophylactic strategies against malaria. |
| format | Article |
| id | doaj-art-0ddd829e7f7c41d783d5a0d5c60f0ab5 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-0ddd829e7f7c41d783d5a0d5c60f0ab52025-02-03T01:10:41ZengWileyMediators of Inflammation0962-93511466-18612014-01-01201410.1155/2014/362605362605Immune Evasion Strategies of Pre-Erythrocytic Malaria ParasitesHong Zheng0Zhangping Tan1Wenyue Xu2Department of Pathogenic Biology, Third Military Medical University, Chongqing 400038, ChinaDepartment of Pathogenic Biology, Third Military Medical University, Chongqing 400038, ChinaDepartment of Pathogenic Biology, Third Military Medical University, Chongqing 400038, ChinaMalaria is a mosquito-borne infectious disease of humans. It begins with a bite from an infected female Anopheles mosquito and leads to the development of the pre-erythrocytic and blood stages. Blood-stage infection is the exclusive cause of clinical symptoms of malaria. In contrast, the pre-erythrocytic stage is clinically asymptomatic and could be an excellent target for preventive therapies. Although the robust host immune responses limit the development of the liver stage, malaria parasites have also evolved strategies to suppress host defenses at the pre-erythrocytic stage. This paper reviews the immune evasion strategies of malaria parasites at the pre-erythrocytic stage, which could provide us with potential targets to design prophylactic strategies against malaria.http://dx.doi.org/10.1155/2014/362605 |
| spellingShingle | Hong Zheng Zhangping Tan Wenyue Xu Immune Evasion Strategies of Pre-Erythrocytic Malaria Parasites Mediators of Inflammation |
| title | Immune Evasion Strategies of Pre-Erythrocytic Malaria Parasites |
| title_full | Immune Evasion Strategies of Pre-Erythrocytic Malaria Parasites |
| title_fullStr | Immune Evasion Strategies of Pre-Erythrocytic Malaria Parasites |
| title_full_unstemmed | Immune Evasion Strategies of Pre-Erythrocytic Malaria Parasites |
| title_short | Immune Evasion Strategies of Pre-Erythrocytic Malaria Parasites |
| title_sort | immune evasion strategies of pre erythrocytic malaria parasites |
| url | http://dx.doi.org/10.1155/2014/362605 |
| work_keys_str_mv | AT hongzheng immuneevasionstrategiesofpreerythrocyticmalariaparasites AT zhangpingtan immuneevasionstrategiesofpreerythrocyticmalariaparasites AT wenyuexu immuneevasionstrategiesofpreerythrocyticmalariaparasites |