Personalized-dose Covid-19 vaccination in a wave of virus Variants of Concern: Trading individual efficacy for societal benefit
<img src=" https://s3.amazonaws.com/production.scholastica/article/26101/large/prnano_672021_ga.jpg?1628005936"> Limited vaccine supplies and virus variants of concern threaten to prolong the COVID-19 pandemic. The elderly dies more frequently, but the younger drives disease transmi...
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| Format: | Article |
| Language: | English |
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Andover House Inc.
2021-07-01
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| Series: | Precision Nanomedicine |
| Online Access: | https://doi.org/10.33218/001c.26101 |
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| _version_ | 1849328564942405632 |
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| author | Patrick Hunziker |
| author_facet | Patrick Hunziker |
| author_sort | Patrick Hunziker |
| collection | DOAJ |
| description | <img src=" https://s3.amazonaws.com/production.scholastica/article/26101/large/prnano_672021_ga.jpg?1628005936">
Limited vaccine supplies and virus variants of concern threaten to prolong the COVID-19 pandemic. The elderly dies more frequently, but the younger drives disease transmission. Here, we explore strategies that trade individual vaccine efficacy for increased numbers of vaccinations by personalized vaccine dosing during the onset of a wave of virus variants of concern. The model incorporates U.S. demographic and epidemic data and vaccine characteristics. We find that broad, personalized-dose vaccination, trading individual efficacy for vaccination speed and societal benefit, mitigates an infection wave of highly infectious variants of concern better and overcomes the pandemic faster than conventional “elderly first” strategies. This strategy implies that on a global scale, tailoring vaccine dose and vaccination strategy to the pandemic phase and demographic characteristics may have significant potential for minimizing deaths and quickly mastering the pandemic. |
| format | Article |
| id | doaj-art-0ddb15e48b43488181aedeaa053e02f7 |
| institution | Kabale University |
| issn | 2639-9431 |
| language | English |
| publishDate | 2021-07-01 |
| publisher | Andover House Inc. |
| record_format | Article |
| series | Precision Nanomedicine |
| spelling | doaj-art-0ddb15e48b43488181aedeaa053e02f72025-08-20T03:47:33ZengAndover House Inc.Precision Nanomedicine2639-94312021-07-014310.33218/001c.26101Personalized-dose Covid-19 vaccination in a wave of virus Variants of Concern: Trading individual efficacy for societal benefitPatrick Hunziker<img src=" https://s3.amazonaws.com/production.scholastica/article/26101/large/prnano_672021_ga.jpg?1628005936"> Limited vaccine supplies and virus variants of concern threaten to prolong the COVID-19 pandemic. The elderly dies more frequently, but the younger drives disease transmission. Here, we explore strategies that trade individual vaccine efficacy for increased numbers of vaccinations by personalized vaccine dosing during the onset of a wave of virus variants of concern. The model incorporates U.S. demographic and epidemic data and vaccine characteristics. We find that broad, personalized-dose vaccination, trading individual efficacy for vaccination speed and societal benefit, mitigates an infection wave of highly infectious variants of concern better and overcomes the pandemic faster than conventional “elderly first” strategies. This strategy implies that on a global scale, tailoring vaccine dose and vaccination strategy to the pandemic phase and demographic characteristics may have significant potential for minimizing deaths and quickly mastering the pandemic.https://doi.org/10.33218/001c.26101 |
| spellingShingle | Patrick Hunziker Personalized-dose Covid-19 vaccination in a wave of virus Variants of Concern: Trading individual efficacy for societal benefit Precision Nanomedicine |
| title | Personalized-dose Covid-19 vaccination in a wave of virus Variants of Concern: Trading individual efficacy for societal benefit |
| title_full | Personalized-dose Covid-19 vaccination in a wave of virus Variants of Concern: Trading individual efficacy for societal benefit |
| title_fullStr | Personalized-dose Covid-19 vaccination in a wave of virus Variants of Concern: Trading individual efficacy for societal benefit |
| title_full_unstemmed | Personalized-dose Covid-19 vaccination in a wave of virus Variants of Concern: Trading individual efficacy for societal benefit |
| title_short | Personalized-dose Covid-19 vaccination in a wave of virus Variants of Concern: Trading individual efficacy for societal benefit |
| title_sort | personalized dose covid 19 vaccination in a wave of virus variants of concern trading individual efficacy for societal benefit |
| url | https://doi.org/10.33218/001c.26101 |
| work_keys_str_mv | AT patrickhunziker personalizeddosecovid19vaccinationinawaveofvirusvariantsofconcerntradingindividualefficacyforsocietalbenefit |