MicroRNA-4516 in extracellular vesicles-derived mesenchymal stem cells suppressed integrin αV-mediated lung fibrosis

MicroRNA-4516 in extracellular vesicles-derived mesenchymal stem cells suppressed integrin αV-mediated lung fibrosis

Abstract Background Idiopathic pulmonary fibrosis (IPF) is characterized by the recruitment of lung fibroblasts to sites within the lung interstitium, along with the differentiation of myofibroblasts induced by transforming growth factor (TGF)-β1, a mediator of fibrosis, which, in turn, leads to acc...

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Main Authors: Issei Sumiyoshi, Shinsaku Togo, Junko Watanabe, Izumi Kaneko, Seiji Uzu, Toshiya Yonekura, Tomoya Komatsu, Motoyasu Kato, Shun Nakazawa, Hiroaki Motomura, Yusuke Ochi, Kotaro Kadoya, Hiroaki Ihara, Kazuaki Hoshi, Hideya Kitamura, Takashi Ogura, Kazuhisa Takahashi
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Stem Cell Research & Therapy
Subjects:
Exosomes
Fibroblast
MiRNA
Pulmonary fibrosis
Online Access:https://doi.org/10.1186/s13287-025-04559-0
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