The theory, technology, and application of terahertz metamaterial biosensors: A review
Terahertz metamaterial biosensors combine terahertz time-domain spectroscopy with metamaterial sensing to provide a sensitive detection platform for a variety of targets, including biological molecules, proteins, cells, and viruses. These biosensors are characterized by their rapid response, sensiti...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co. Ltd.
2025-03-01
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| Series: | Fundamental Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667325824004606 |
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| author | Xiaoke Wei Chuanlu Ren Bingwei Liu Yan Peng Songlin Zhuang |
| author_facet | Xiaoke Wei Chuanlu Ren Bingwei Liu Yan Peng Songlin Zhuang |
| author_sort | Xiaoke Wei |
| collection | DOAJ |
| description | Terahertz metamaterial biosensors combine terahertz time-domain spectroscopy with metamaterial sensing to provide a sensitive detection platform for a variety of targets, including biological molecules, proteins, cells, and viruses. These biosensors are characterized by their rapid response, sensitivity, non-destructive, label-free operation, minimal sample requirement, and user-friendly design, which also allows for integration with various technical approaches. Advancing beyond traditional biosensors, terahertz metamaterial biosensors facilitate rapid and non-destructive trace detection in biomedical applications, contributing to timely diagnosis and early screening of diseases. In this paper, the theoretical basis and advanced progress of these biosensors are discussed in depth, focusing on three key areas: improving the sensitivity and specificity, and reducing the influence of water absorption in biological samples. This paper also analyzes the potential and future development of these biosensors for expanded applications. It highlights their potential for multi-band tuning, intelligent operations, and flexible, wearable biosensor applications. This review provides a valuable reference for the follow-up research and application of terahertz metamaterial biosensors in the field of biomedical detection. |
| format | Article |
| id | doaj-art-0dd41411e6c14eb6befe4c8a75513690 |
| institution | OA Journals |
| issn | 2667-3258 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | KeAi Communications Co. Ltd. |
| record_format | Article |
| series | Fundamental Research |
| spelling | doaj-art-0dd41411e6c14eb6befe4c8a755136902025-08-20T02:10:09ZengKeAi Communications Co. Ltd.Fundamental Research2667-32582025-03-015257158510.1016/j.fmre.2024.11.008The theory, technology, and application of terahertz metamaterial biosensors: A reviewXiaoke Wei0Chuanlu Ren1Bingwei Liu2Yan Peng3Songlin Zhuang4Shidong Hospital Affiliated to University of Shanghai for Science and Technology, Terahertz Technology Innovation Research Institute, Terahertz Spectrum and Imaging Technology Cooperative Innovation Center, Shanghai Key Lab of Modern Optical System, University of Shanghai for Science and Technology, Shanghai 200093, ChinaDepartment of Clinical Laboratory, The 904th Hospital of Joint Logistic Support Force of PLA, Wuxi 214044, ChinaShidong Hospital Affiliated to University of Shanghai for Science and Technology, Terahertz Technology Innovation Research Institute, Terahertz Spectrum and Imaging Technology Cooperative Innovation Center, Shanghai Key Lab of Modern Optical System, University of Shanghai for Science and Technology, Shanghai 200093, ChinaShidong Hospital Affiliated to University of Shanghai for Science and Technology, Terahertz Technology Innovation Research Institute, Terahertz Spectrum and Imaging Technology Cooperative Innovation Center, Shanghai Key Lab of Modern Optical System, University of Shanghai for Science and Technology, Shanghai 200093, China; Corresponding author.Shidong Hospital Affiliated to University of Shanghai for Science and Technology, Terahertz Technology Innovation Research Institute, Terahertz Spectrum and Imaging Technology Cooperative Innovation Center, Shanghai Key Lab of Modern Optical System, University of Shanghai for Science and Technology, Shanghai 200093, ChinaTerahertz metamaterial biosensors combine terahertz time-domain spectroscopy with metamaterial sensing to provide a sensitive detection platform for a variety of targets, including biological molecules, proteins, cells, and viruses. These biosensors are characterized by their rapid response, sensitivity, non-destructive, label-free operation, minimal sample requirement, and user-friendly design, which also allows for integration with various technical approaches. Advancing beyond traditional biosensors, terahertz metamaterial biosensors facilitate rapid and non-destructive trace detection in biomedical applications, contributing to timely diagnosis and early screening of diseases. In this paper, the theoretical basis and advanced progress of these biosensors are discussed in depth, focusing on three key areas: improving the sensitivity and specificity, and reducing the influence of water absorption in biological samples. This paper also analyzes the potential and future development of these biosensors for expanded applications. It highlights their potential for multi-band tuning, intelligent operations, and flexible, wearable biosensor applications. This review provides a valuable reference for the follow-up research and application of terahertz metamaterial biosensors in the field of biomedical detection.http://www.sciencedirect.com/science/article/pii/S2667325824004606TerahertzMetamaterial biosensorsSensitivitySpecific detectionWater absorption |
| spellingShingle | Xiaoke Wei Chuanlu Ren Bingwei Liu Yan Peng Songlin Zhuang The theory, technology, and application of terahertz metamaterial biosensors: A review Fundamental Research Terahertz Metamaterial biosensors Sensitivity Specific detection Water absorption |
| title | The theory, technology, and application of terahertz metamaterial biosensors: A review |
| title_full | The theory, technology, and application of terahertz metamaterial biosensors: A review |
| title_fullStr | The theory, technology, and application of terahertz metamaterial biosensors: A review |
| title_full_unstemmed | The theory, technology, and application of terahertz metamaterial biosensors: A review |
| title_short | The theory, technology, and application of terahertz metamaterial biosensors: A review |
| title_sort | theory technology and application of terahertz metamaterial biosensors a review |
| topic | Terahertz Metamaterial biosensors Sensitivity Specific detection Water absorption |
| url | http://www.sciencedirect.com/science/article/pii/S2667325824004606 |
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