Anti-viral memory T cell responses in the absence of IgG production in a COVID-19 convalescent individual

Anti-viral memory T cell responses in the absence of IgG production in a COVID-19 convalescent individual

Cellular and humoral immunity are both important in host defense against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although defects in SARS-CoV-2-specific T cell immunity have been found in patients with severe lung pathology, it is still largely unclear whether virus-specific T...

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Main Authors: Ni Ling, Ye Fang, Qiao Qin, Feng Yu, Yang Yazheng, Zhao Hui, Zhang Li-Nan, Cheng Meng-Li, Zhu Gengzhen, Li Xiaoli, Zhong Xuan, Li Ruifeng, Qin Cheng-Feng, Chen Fang, Dong Chen
Format: Article
Language:English
Published: Science Press 2022-03-01
Series:National Science Open
Subjects:
SARS-CoV-2
adaptive immunity
T cells
memory
Online Access:https://www.sciengine.com/doi/10.1360/nso/20220009
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Summary:Cellular and humoral immunity are both important in host defense against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although defects in SARS-CoV-2-specific T cell immunity have been found in patients with severe lung pathology, it is still largely unclear whether virus-specific T cells are sufficient for host protection. Here, we found that in a previously characterized cohort of convalescent subjects, one individual, though lacking detectable anti-viral neutralizing IgG antibodies, showed virus-specific T cell responses, both in CD4<sup>+</sup> and CD8<sup>+</sup> T cells. SARS-CoV-2-specific T cells in this and other individuals are maintained for up to <sc>10 months.</sc> This study thus further supports a critical role of T cells in host defense against SARS-CoV-2, offering new insights into the design and evaluation of COVID-19 vaccines.
ISSN:2097-1168

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