P-Cadherin Expression in Feline Mammary Tissues
The search for molecular markers in the feline mammary gland, namely, the adhesion molecules belonging to the cadherin family, is useful in the understanding of the development of mammary carcinomas in felines and humans. To study P-cadherin expression in the feline mammary gland, 61 samples of norm...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | Veterinary Medicine International |
| Online Access: | http://dx.doi.org/10.1155/2012/687424 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849308174363918336 |
|---|---|
| author | Ana Catarina Figueira Ana Sofia Teodósio Júlio Carvalheira Manuela Lacerda Augusto de Matos Fátima Gärtner |
| author_facet | Ana Catarina Figueira Ana Sofia Teodósio Júlio Carvalheira Manuela Lacerda Augusto de Matos Fátima Gärtner |
| author_sort | Ana Catarina Figueira |
| collection | DOAJ |
| description | The search for molecular markers in the feline mammary gland, namely, the adhesion molecules belonging to the cadherin family, is useful in the understanding of the development of mammary carcinomas in felines and humans. To study P-cadherin expression in the feline mammary gland, 61 samples of normal (n=4), hyperplastic (n=12), and neoplastic (n=45) feline mammary tissues were examined. In both normal and hyperplastic mammary tissues as well as in benign tumours, P-cadherin immunolabelling was restricted to myoepithelial cells. In malignant tumours, however, there was an aberrant epithelial P-cadherin immunoexpression in 64.1% (n=25) of cases, with a membranous and/or cytoplasmic pattern of distribution. A statistically significant relationship was seen between epithelial P-cadherin expression and malignant mammary lesions (P=0.0001). In malignant mammary tumours, there was likewise a statistically significant relationship between aberrant P-cadherin immunoexpression and histological grade (P=0.0132). Aberrant epithelial P-cadherin expression seems to be related to malignancy in the feline mammary gland. To confirm the results of this investigation, further studies with larger samples and follow-up studies are warranted. |
| format | Article |
| id | doaj-art-0dca7dab59aa47868152ba454bab9e75 |
| institution | Kabale University |
| issn | 2090-8113 2042-0048 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Veterinary Medicine International |
| spelling | doaj-art-0dca7dab59aa47868152ba454bab9e752025-08-20T03:54:30ZengWileyVeterinary Medicine International2090-81132042-00482012-01-01201210.1155/2012/687424687424P-Cadherin Expression in Feline Mammary TissuesAna Catarina Figueira0Ana Sofia Teodósio1Júlio Carvalheira2Manuela Lacerda3Augusto de Matos4Fátima Gärtner5Escola Universitária Vasco da Gama (EUVG), Quinta de S. Jorge, Estrada da Conraria, Castelo Viegas, 3040-714 Coimbra, PortugalInstituto Português de Oncologia de Coimbra Francisco Gentil, EPE (IPOCFG,EPE) Avenida Bissaya Barreto, No. 98, 3000-075 Coimbra, PortugalInstituto de Ciências Biomédicas Abel Salazar, Universidade do Porto (ICBAS-UP), Rua de Jorge Viterbo Ferreira No. 228, 4050-313 Porto, PortugalInstituto Português de Oncologia de Coimbra Francisco Gentil, EPE (IPOCFG,EPE) Avenida Bissaya Barreto, No. 98, 3000-075 Coimbra, PortugalInstituto de Ciências Biomédicas Abel Salazar, Universidade do Porto (ICBAS-UP), Rua de Jorge Viterbo Ferreira No. 228, 4050-313 Porto, PortugalInstituto de Ciências Biomédicas Abel Salazar, Universidade do Porto (ICBAS-UP), Rua de Jorge Viterbo Ferreira No. 228, 4050-313 Porto, PortugalThe search for molecular markers in the feline mammary gland, namely, the adhesion molecules belonging to the cadherin family, is useful in the understanding of the development of mammary carcinomas in felines and humans. To study P-cadherin expression in the feline mammary gland, 61 samples of normal (n=4), hyperplastic (n=12), and neoplastic (n=45) feline mammary tissues were examined. In both normal and hyperplastic mammary tissues as well as in benign tumours, P-cadherin immunolabelling was restricted to myoepithelial cells. In malignant tumours, however, there was an aberrant epithelial P-cadherin immunoexpression in 64.1% (n=25) of cases, with a membranous and/or cytoplasmic pattern of distribution. A statistically significant relationship was seen between epithelial P-cadherin expression and malignant mammary lesions (P=0.0001). In malignant mammary tumours, there was likewise a statistically significant relationship between aberrant P-cadherin immunoexpression and histological grade (P=0.0132). Aberrant epithelial P-cadherin expression seems to be related to malignancy in the feline mammary gland. To confirm the results of this investigation, further studies with larger samples and follow-up studies are warranted.http://dx.doi.org/10.1155/2012/687424 |
| spellingShingle | Ana Catarina Figueira Ana Sofia Teodósio Júlio Carvalheira Manuela Lacerda Augusto de Matos Fátima Gärtner P-Cadherin Expression in Feline Mammary Tissues Veterinary Medicine International |
| title | P-Cadherin Expression in Feline Mammary Tissues |
| title_full | P-Cadherin Expression in Feline Mammary Tissues |
| title_fullStr | P-Cadherin Expression in Feline Mammary Tissues |
| title_full_unstemmed | P-Cadherin Expression in Feline Mammary Tissues |
| title_short | P-Cadherin Expression in Feline Mammary Tissues |
| title_sort | p cadherin expression in feline mammary tissues |
| url | http://dx.doi.org/10.1155/2012/687424 |
| work_keys_str_mv | AT anacatarinafigueira pcadherinexpressioninfelinemammarytissues AT anasofiateodosio pcadherinexpressioninfelinemammarytissues AT juliocarvalheira pcadherinexpressioninfelinemammarytissues AT manuelalacerda pcadherinexpressioninfelinemammarytissues AT augustodematos pcadherinexpressioninfelinemammarytissues AT fatimagartner pcadherinexpressioninfelinemammarytissues |