EPA and DHA inhibit LDL-induced upregulation of human adipose tissue NLRP3 inflammasome/IL-1β pathway and its association with diabetes risk factors

EPA and DHA inhibit LDL-induced upregulation of human adipose tissue NLRP3 inflammasome/IL-1β pathway and its association with diabetes risk factors

Abstract Elevated numbers of atherogenic lipoproteins (apoB) predict the incidence of type 2 diabetes (T2D). We reported that this may be mediated via the activation of the NLRP3 inflammasome, as low-density lipoproteins (LDL) induce interleukin-1 beta (IL-1β) secretion from human white adipose tiss...

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Bibliographic Details
Main Authors: Valérie Lamantia, Simon Bissonnette, Myriam Beaudry, Yannick Cyr, Christine Des Rosiers, Alexis Baass, May Faraj
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Subjects:
Marine-source omega-3 fatty acids
NLRP3 inflammasome and interleukin-1 beta
Plasma apoB
Human adipose tissue
Type 2 diabetes
Online Access:https://doi.org/10.1038/s41598-024-73672-6
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